Leprosy therapy and pharmacogenetics

Detalhes bibliográficos
Autor(a) principal: BEIGUELMAN, B.
Data de Publicação: 1976
Tipo de documento: Artigo
Idioma: por
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35676
Resumo: Some pharmacogenetic traits which are human genetic polymorphisms and that influence the action of 4, V-piaminodiphenylsulfone (DDS), the most widely used drug in leprosy therapy, were analysed. Special attention was given to the polymorphisms of acetyltransferase, glucose-6-phosphate dehydrogenase and NADH methemoglobin reductase. Besides the review and critical analysis of the pertinent literature, suggestions for further investigations are presented.
id ILSL-1_82fd2ef222bb05998f6c375c2d4d78d7
oai_identifier_str oai:ojs.periodicos.saude.sp.gov.br:article/35676
network_acronym_str ILSL-1
network_name_str Hansenologia Internationalis (Online)
repository_id_str
spelling Leprosy therapy and pharmacogeneticsTerapêutica da lepra e farmacogenéticaHanseníaseDapsonaGenéticaFarmacogenéticaTerapêuticaHanseniasisTherapyDapsoneGeneticsPharmacogenetinsSome pharmacogenetic traits which are human genetic polymorphisms and that influence the action of 4, V-piaminodiphenylsulfone (DDS), the most widely used drug in leprosy therapy, were analysed. Special attention was given to the polymorphisms of acetyltransferase, glucose-6-phosphate dehydrogenase and NADH methemoglobin reductase. Besides the review and critical analysis of the pertinent literature, suggestions for further investigations are presented.No presente trabalho foram analisadas algumas características farmacogeneticas que são polimorfismos genéticos humanos e que influenciam a ação da 4,4'-diaminodifenilsulfona (DDS), o medicamento mais amplamente empregado na terapêutica da lepra. Deu-se atenção especial aos polimorfismos da acetiltransferase, da desidrogenase de 6-fosfato de glicose e da NADH redutase de metemoglobina. Além da revisão e análise critica da literatura, foram apresentadas sugestões para novas investigações.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo1976-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3567610.47878/hi.1976.v1.35676Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 1 No. 1 (1976); 61-78Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 1 n. 1 (1976); 61-781982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35676/34085BEIGUELMAN, B.info:eu-repo/semantics/openAccess2021-06-06T05:36:41Zoai:ojs.periodicos.saude.sp.gov.br:article/35676Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-06-06T05:36:41Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Leprosy therapy and pharmacogenetics
Terapêutica da lepra e farmacogenética
title Leprosy therapy and pharmacogenetics
spellingShingle Leprosy therapy and pharmacogenetics
BEIGUELMAN, B.
Hanseníase
Dapsona
Genética
Farmacogenética
Terapêutica
Hanseniasis
Therapy
Dapsone
Genetics
Pharmacogenetins
title_short Leprosy therapy and pharmacogenetics
title_full Leprosy therapy and pharmacogenetics
title_fullStr Leprosy therapy and pharmacogenetics
title_full_unstemmed Leprosy therapy and pharmacogenetics
title_sort Leprosy therapy and pharmacogenetics
author BEIGUELMAN, B.
author_facet BEIGUELMAN, B.
author_role author
dc.contributor.author.fl_str_mv BEIGUELMAN, B.
dc.subject.por.fl_str_mv Hanseníase
Dapsona
Genética
Farmacogenética
Terapêutica
Hanseniasis
Therapy
Dapsone
Genetics
Pharmacogenetins
topic Hanseníase
Dapsona
Genética
Farmacogenética
Terapêutica
Hanseniasis
Therapy
Dapsone
Genetics
Pharmacogenetins
description Some pharmacogenetic traits which are human genetic polymorphisms and that influence the action of 4, V-piaminodiphenylsulfone (DDS), the most widely used drug in leprosy therapy, were analysed. Special attention was given to the polymorphisms of acetyltransferase, glucose-6-phosphate dehydrogenase and NADH methemoglobin reductase. Besides the review and critical analysis of the pertinent literature, suggestions for further investigations are presented.
publishDate 1976
dc.date.none.fl_str_mv 1976-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35676
10.47878/hi.1976.v1.35676
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35676
identifier_str_mv 10.47878/hi.1976.v1.35676
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35676/34085
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 1 No. 1 (1976); 61-78
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 1 n. 1 (1976); 61-78
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1796797580138512384

Registros relacionados