IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/35944 |
Resumo: | The study of the IgG subclasses of antibodies across the clinical spectrum of leprosy id not reveal differences that could be related to the Th1/Th2 dichotomy; the predominance of antibodies of the IgG1, 2 and 3 subclasses suggest a possible Th1 response across the spectrum in Venezuelan patients. In contrast, the anergic form of American cutaneous leishmaniasis was characterized by a strong IgG4 specific antibody response, suggesting a Th2 response, while localized forms of the disease appeared to be associated with responses of the Th1 type. Persisting antibodies to phenolic glyco- lipid-I in a small percentage of clinically inactive multibacillary patients may reflect differences in the catabolism of this unusual antigen, since persistence was not associated with a unique initial IgG subclass response to a complex extract of Mycobacterium leprae antigens. |
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Hansenologia Internationalis (Online) |
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IgG Antibodies in Leprosy and Their Relation to Thl/Th2 ResponsesThe study of the IgG subclasses of antibodies across the clinical spectrum of leprosy id not reveal differences that could be related to the Th1/Th2 dichotomy; the predominance of antibodies of the IgG1, 2 and 3 subclasses suggest a possible Th1 response across the spectrum in Venezuelan patients. In contrast, the anergic form of American cutaneous leishmaniasis was characterized by a strong IgG4 specific antibody response, suggesting a Th2 response, while localized forms of the disease appeared to be associated with responses of the Th1 type. Persisting antibodies to phenolic glyco- lipid-I in a small percentage of clinically inactive multibacillary patients may reflect differences in the catabolism of this unusual antigen, since persistence was not associated with a unique initial IgG subclass response to a complex extract of Mycobacterium leprae antigens.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo1998-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3594410.47878/hi.1998.v23.35944Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 23 No. Especial (1998); 133-136Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 23 n. Especial (1998); 133-1361982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLenghttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35944/34287Ulrich, MarianRodriguez, VestaliaConvit, Marta Centeno and Jacintoinfo:eu-repo/semantics/openAccess2022-03-22T14:56:25Zoai:ojs.periodicos.saude.sp.gov.br:article/35944Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2022-03-22T14:56:25Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
title |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
spellingShingle |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses Ulrich, Marian |
title_short |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
title_full |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
title_fullStr |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
title_full_unstemmed |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
title_sort |
IgG Antibodies in Leprosy and Their Relation to Thl/Th2 Responses |
author |
Ulrich, Marian |
author_facet |
Ulrich, Marian Rodriguez, Vestalia Convit, Marta Centeno and Jacinto |
author_role |
author |
author2 |
Rodriguez, Vestalia Convit, Marta Centeno and Jacinto |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Ulrich, Marian Rodriguez, Vestalia Convit, Marta Centeno and Jacinto |
description |
The study of the IgG subclasses of antibodies across the clinical spectrum of leprosy id not reveal differences that could be related to the Th1/Th2 dichotomy; the predominance of antibodies of the IgG1, 2 and 3 subclasses suggest a possible Th1 response across the spectrum in Venezuelan patients. In contrast, the anergic form of American cutaneous leishmaniasis was characterized by a strong IgG4 specific antibody response, suggesting a Th2 response, while localized forms of the disease appeared to be associated with responses of the Th1 type. Persisting antibodies to phenolic glyco- lipid-I in a small percentage of clinically inactive multibacillary patients may reflect differences in the catabolism of this unusual antigen, since persistence was not associated with a unique initial IgG subclass response to a complex extract of Mycobacterium leprae antigens. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35944 10.47878/hi.1998.v23.35944 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35944 |
identifier_str_mv |
10.47878/hi.1998.v23.35944 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/35944/34287 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 23 No. Especial (1998); 133-136 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 23 n. Especial (1998); 133-136 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797580159483904 |