Patologia da involução da fibrose periportal na esquistossomose humana

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton A.
Data de Publicação: 1992
Outros Autores: Peixoto, Ediriomar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28932
Resumo: Optical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy.
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spelling Patologia da involução da fibrose periportal na esquistossomose humana Pathology of periportal fibrosis involution in human schistosomiasis Matrix degradationFibrosisSchistosomiasisCollagenChemotherapy Optical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy. Um estudo feito com microscopia ótica e eletrônica permitiu verificar sinais de degradação da matriz extracelular na fibrose periportal humana causada pela esquistossomose avançada. O material de estudo proveio de 14 biópsias hepáticas em cunha feitas em portadores de esquistossomose hepato-esplênica, no momento em que eles foram submetidos a cirurgia para o alívio das manifestações de hipertensão porta. Além da presença de áreas focais de rarefação, fragmentação e dispersão dos feixes colgenos, os espaços porta alargados e fibrosados também mostraram hiperplasia do tecido elástico e dissociação de fibras musculares lisas em seguida à destruição de ramos da veia porta. Os ovos do parasito eram escassos nas secções histológicas. A degradação da matriz provavelmente representa processo involutivo relacionado com a progressiva diminuição da agressão parasitária, o que pode ocorrer espontaneamente em casos de longa duração ou após a cura pela quimioterapia. As alterações indicativas de degradação da matriz aqui descritas representam provavelmente a face morfológica da involução da fibrose periportal que vem sendo atualmente documentada pela ultrasonografia em pacientes hepato-esplênicos submetidos à quimioterapia curativa. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28932Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 4 (1992); 263-272 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 4 (1992); 263-272 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 4 (1992); 263-272 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28932/30789Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessAndrade, Zilton A.Peixoto, Ediriomar2012-07-02T01:33:07Zoai:revistas.usp.br:article/28932Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:41.815657Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Patologia da involução da fibrose periportal na esquistossomose humana
Pathology of periportal fibrosis involution in human schistosomiasis
title Patologia da involução da fibrose periportal na esquistossomose humana
spellingShingle Patologia da involução da fibrose periportal na esquistossomose humana
Andrade, Zilton A.
Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
title_short Patologia da involução da fibrose periportal na esquistossomose humana
title_full Patologia da involução da fibrose periportal na esquistossomose humana
title_fullStr Patologia da involução da fibrose periportal na esquistossomose humana
title_full_unstemmed Patologia da involução da fibrose periportal na esquistossomose humana
title_sort Patologia da involução da fibrose periportal na esquistossomose humana
author Andrade, Zilton A.
author_facet Andrade, Zilton A.
Peixoto, Ediriomar
author_role author
author2 Peixoto, Ediriomar
author2_role author
dc.contributor.author.fl_str_mv Andrade, Zilton A.
Peixoto, Ediriomar
dc.subject.por.fl_str_mv Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
topic Matrix degradation
Fibrosis
Schistosomiasis
Collagen
Chemotherapy
description Optical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy.
publishDate 1992
dc.date.none.fl_str_mv 1992-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28932
url https://www.revistas.usp.br/rimtsp/article/view/28932
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28932/30789
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 4 (1992); 263-272
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 4 (1992); 263-272
Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 4 (1992); 263-272
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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