Quality of life in Brazilian patients with treated or untreated chronic hepatitis C

• Autor(a) principal: Perlin, Cássio Marques
• Data de Publicação: 2017
• Outros Autores: Ferreira, Vinicius Lins, Borba, Helena Hiemisch Lobo, Wiens, Astrid, Ivantes, Cláudia Alexandra Pontes, Lenzi, Luana, Pontarolo, Roberto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/143754
• topic: Quality of life; Hepatitis C treatment; SF-36; CLDQ

Introduction: Multiple factors negatively affect the quality of life of patients infected with hepatitis C virus. This study aims to evaluate the effect of pharmacological treatment on the quality of life of these individuals. Methods: This is a cross-sectional study conducted in two Southern Brazilian centers that used two instruments (a generic and a specific one) for measuring the quality of life in patients with chronic hepatitis C: the Short Form-36 (SF-36); and the Chronic Liver Disease Questionnaire (CLDQ) for liver disease. We included patients from two centers without any treatment (control group), or receiving medication (peginterferon + ribavirin ± telaprevir or boceprevir, i.e., respectively, dual, and triple therapies). Results: One hundred and forty-seven patients were included. Patients under treatment (n = 86) had a lower score in 7 of the 8 SF-36 domains, with statistical significance (p