Acute pancreatitis associated with multibacillary polychemotherapy for leprosy

Detalhes bibliográficos
Autor(a) principal: Maciel, Lucas Guimarães
Data de Publicação: 2021
Outros Autores: França, Lucas Ataídes Amorim, Deus, Bárbara Veloso de, Formiga, Caio César Siqueira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/191803
Resumo: Acute pancreatitis (AP) is an inflammatory disease associated with abdominal pain and elevated serum pancreatic enzymes. The most common etiologies are gallstones and alcoholism. Drug-induced AP is quite rare, lacks a solid understanding and has been occasionally reported. The diagnosis requires a great suspicion and a careful exclusion of other causes. We present a case of a 37-year-old man, previously diagnosed with leprosy that developed acute pancreatitis after starting the multibacillary polychemotherapy (PCT/MB). After a month of treatment and the discontinuation of the PCT/MB, the therapy was restarted and a new episode of AP occurred. Three months after this last episode, the PCT/MB was reintroduced, changing one of the medications and the patient had no recurrence of AP or other reactions. Therefore, it is important to take into account that there is a risk of acute pancreatitis in patients on multidrug therapy (MDT) for leprosy.
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spelling Acute pancreatitis associated with multibacillary polychemotherapy for leprosyPancreatitisLeprosyMultibaccilary polychemotherapyDapsoneRifampicinAcute pancreatitis (AP) is an inflammatory disease associated with abdominal pain and elevated serum pancreatic enzymes. The most common etiologies are gallstones and alcoholism. Drug-induced AP is quite rare, lacks a solid understanding and has been occasionally reported. The diagnosis requires a great suspicion and a careful exclusion of other causes. We present a case of a 37-year-old man, previously diagnosed with leprosy that developed acute pancreatitis after starting the multibacillary polychemotherapy (PCT/MB). After a month of treatment and the discontinuation of the PCT/MB, the therapy was restarted and a new episode of AP occurred. Three months after this last episode, the PCT/MB was reintroduced, changing one of the medications and the patient had no recurrence of AP or other reactions. Therefore, it is important to take into account that there is a risk of acute pancreatitis in patients on multidrug therapy (MDT) for leprosy.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-10-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/19180310.1590/S1678-9946202163073Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e73Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e73Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e731678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/191803/176710Copyright (c) 2021 Lucas Guimarães Maciel, Lucas Ataídes Amorim França, Bárbara Veloso de Deus, Caio César Siqueira Formigahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessMaciel, Lucas Guimarães França, Lucas Ataídes Amorim Deus, Bárbara Veloso de Formiga, Caio César Siqueira 2022-05-16T13:44:35Zoai:revistas.usp.br:article/191803Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:53:00.005794Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
title Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
spellingShingle Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
Maciel, Lucas Guimarães
Pancreatitis
Leprosy
Multibaccilary polychemotherapy
Dapsone
Rifampicin
title_short Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
title_full Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
title_fullStr Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
title_full_unstemmed Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
title_sort Acute pancreatitis associated with multibacillary polychemotherapy for leprosy
author Maciel, Lucas Guimarães
author_facet Maciel, Lucas Guimarães
França, Lucas Ataídes Amorim
Deus, Bárbara Veloso de
Formiga, Caio César Siqueira
author_role author
author2 França, Lucas Ataídes Amorim
Deus, Bárbara Veloso de
Formiga, Caio César Siqueira
author2_role author
author
author
dc.contributor.author.fl_str_mv Maciel, Lucas Guimarães
França, Lucas Ataídes Amorim
Deus, Bárbara Veloso de
Formiga, Caio César Siqueira
dc.subject.por.fl_str_mv Pancreatitis
Leprosy
Multibaccilary polychemotherapy
Dapsone
Rifampicin
topic Pancreatitis
Leprosy
Multibaccilary polychemotherapy
Dapsone
Rifampicin
description Acute pancreatitis (AP) is an inflammatory disease associated with abdominal pain and elevated serum pancreatic enzymes. The most common etiologies are gallstones and alcoholism. Drug-induced AP is quite rare, lacks a solid understanding and has been occasionally reported. The diagnosis requires a great suspicion and a careful exclusion of other causes. We present a case of a 37-year-old man, previously diagnosed with leprosy that developed acute pancreatitis after starting the multibacillary polychemotherapy (PCT/MB). After a month of treatment and the discontinuation of the PCT/MB, the therapy was restarted and a new episode of AP occurred. Three months after this last episode, the PCT/MB was reintroduced, changing one of the medications and the patient had no recurrence of AP or other reactions. Therefore, it is important to take into account that there is a risk of acute pancreatitis in patients on multidrug therapy (MDT) for leprosy.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/191803
10.1590/S1678-9946202163073
url https://www.revistas.usp.br/rimtsp/article/view/191803
identifier_str_mv 10.1590/S1678-9946202163073
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/191803/176710
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e73
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e73
Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e73
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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