Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/169549 |
Resumo: | Candida is one of the most frequent pathogens of bloodstream infections, which is associated with high morbidity and mortality rates. Rapid immunological detection methods are essential in the early diagnosis of candidemia. Anti-mannan is one of host-derived biomarkers against cell wall components of Candida. We conducted this study to evaluate the diagnostic performance of two anti-mannan assays (IgM, IgG) for candidemia through the analysis of 40 candidemia patients, 48 participants with Candida colonization and 213 participants with neither Candida colonization nor Candida infections (13 patients with other bloodstream infections, 145 hospitalized patients and 55 healthy controls). The performance of the two assays were evaluated by calculating their sensitivity and specificity. The sensitivity ranged from 0.78 to 0.80 for the IgM assay and 0.68 to 0.75 for the IgG assay. The specificity ranged from 0.97 to 0.98 for the IgM assay and 0.91 to 0.94 for the IgG assay. The diagnostic performance of the anti-mannan IgM assay was better than that of IgG, with higher sensitivity and specificity. Combining the two assays (positive results of single or both assays are both considered as positive) could improve the sensitivity up to 0.93 (0.79-0.98) and only slightly reduce the specificity (0.93(0.89-0.95)). The anti-mannan IgM, IgG assays are rapid and cost-effective assays that may be probably useful in the diagnosis of candidemia. |
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Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemiaCandidemiaAnti-mannanDiagnosisCandida is one of the most frequent pathogens of bloodstream infections, which is associated with high morbidity and mortality rates. Rapid immunological detection methods are essential in the early diagnosis of candidemia. Anti-mannan is one of host-derived biomarkers against cell wall components of Candida. We conducted this study to evaluate the diagnostic performance of two anti-mannan assays (IgM, IgG) for candidemia through the analysis of 40 candidemia patients, 48 participants with Candida colonization and 213 participants with neither Candida colonization nor Candida infections (13 patients with other bloodstream infections, 145 hospitalized patients and 55 healthy controls). The performance of the two assays were evaluated by calculating their sensitivity and specificity. The sensitivity ranged from 0.78 to 0.80 for the IgM assay and 0.68 to 0.75 for the IgG assay. The specificity ranged from 0.97 to 0.98 for the IgM assay and 0.91 to 0.94 for the IgG assay. The diagnostic performance of the anti-mannan IgM assay was better than that of IgG, with higher sensitivity and specificity. Combining the two assays (positive results of single or both assays are both considered as positive) could improve the sensitivity up to 0.93 (0.79-0.98) and only slightly reduce the specificity (0.93(0.89-0.95)). The anti-mannan IgM, IgG assays are rapid and cost-effective assays that may be probably useful in the diagnosis of candidemia.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2020-05-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/16954910.1590/S1678-9946202062025Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e25Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e25Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e251678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/169549/160550https://www.revistas.usp.br/rimtsp/article/view/169549/160551Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMeng, YanmingKang, MeiLi, DongdongWang, TingtingKuang, ZiweiMa, Ying2020-10-26T17:39:25Zoai:revistas.usp.br:article/169549Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:52.225630Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
title |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
spellingShingle |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia Meng, Yanming Candidemia Anti-mannan Diagnosis |
title_short |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
title_full |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
title_fullStr |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
title_full_unstemmed |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
title_sort |
Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
author |
Meng, Yanming |
author_facet |
Meng, Yanming Kang, Mei Li, Dongdong Wang, Tingting Kuang, Ziwei Ma, Ying |
author_role |
author |
author2 |
Kang, Mei Li, Dongdong Wang, Tingting Kuang, Ziwei Ma, Ying |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Meng, Yanming Kang, Mei Li, Dongdong Wang, Tingting Kuang, Ziwei Ma, Ying |
dc.subject.por.fl_str_mv |
Candidemia Anti-mannan Diagnosis |
topic |
Candidemia Anti-mannan Diagnosis |
description |
Candida is one of the most frequent pathogens of bloodstream infections, which is associated with high morbidity and mortality rates. Rapid immunological detection methods are essential in the early diagnosis of candidemia. Anti-mannan is one of host-derived biomarkers against cell wall components of Candida. We conducted this study to evaluate the diagnostic performance of two anti-mannan assays (IgM, IgG) for candidemia through the analysis of 40 candidemia patients, 48 participants with Candida colonization and 213 participants with neither Candida colonization nor Candida infections (13 patients with other bloodstream infections, 145 hospitalized patients and 55 healthy controls). The performance of the two assays were evaluated by calculating their sensitivity and specificity. The sensitivity ranged from 0.78 to 0.80 for the IgM assay and 0.68 to 0.75 for the IgG assay. The specificity ranged from 0.97 to 0.98 for the IgM assay and 0.91 to 0.94 for the IgG assay. The diagnostic performance of the anti-mannan IgM assay was better than that of IgG, with higher sensitivity and specificity. Combining the two assays (positive results of single or both assays are both considered as positive) could improve the sensitivity up to 0.93 (0.79-0.98) and only slightly reduce the specificity (0.93(0.89-0.95)). The anti-mannan IgM, IgG assays are rapid and cost-effective assays that may be probably useful in the diagnosis of candidemia. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/169549 10.1590/S1678-9946202062025 |
url |
https://www.revistas.usp.br/rimtsp/article/view/169549 |
identifier_str_mv |
10.1590/S1678-9946202062025 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/169549/160550 https://www.revistas.usp.br/rimtsp/article/view/169549/160551 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e25 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e25 Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e25 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951652684726272 |