Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi

Detalhes bibliográficos
Autor(a) principal: Tafuri, Washington Luiz
Data de Publicação: 1989
Outros Autores: Michalick, Marilena Suzan Marques, Dias, Magno, Genaro, Odair, Leite, Virginia Hora Rios, Barbosa, Alfredo José Afonso, Bambirra, Eduardo Alves, Costa, Carlos Alberto Da, Melo, Maria Norma, Mayrink, Wilson
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28654
Resumo: Two naturally infected dogs (male and fema lei from Teófilo Otoni (MG Brazili were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO BR 70 BH46 Leishinania (Leishmanial chagasi strain, endo venous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulo nephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron dense deposits: (3) chronic interstitial nephritis with intense exudation of plasmocytes: (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.
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spelling Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi Estudo, ao microscópio óptico e eletrônico, do rim de caes natural e experimentalmente infectados com Leishmania (Leishmania) chagasi Nefropatia parasitáriaLeishmania (L.) chagasiCalazar canino Two naturally infected dogs (male and fema lei from Teófilo Otoni (MG Brazili were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO BR 70 BH46 Leishinania (Leishmanial chagasi strain, endo venous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulo nephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron dense deposits: (3) chronic interstitial nephritis with intense exudation of plasmocytes: (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms. Os autores estudam os rins de 4 cães infectados com Leishmania (Leishmania) chagasi. Dois animais (um macho e uma fêmea) naturalmente infectados foram sacrificados 18 meses após sua permanência no laboratório. Dois machos foram inoculados por via endovenosa, com lxlO6 promastigotas da cepa MHO/BR/70/BH46 e sacrificados após 18 meses e 2 anos, respectivamente. Em todos os animais os rins estavam lesados. As alterações encontradas foram: (1) glomerulonefrite mesangioproliferativa focal ou difusa, com pronunciada hipertrofia e hiperplasia das células mesangiais e com alargamento da matriz; (2) espessamento da membrana basal com depósitos eletrondensos; (3) nefrite intersticial intertubular crônica com exsudação plasmocitária intensa. (4) degeneração albuminosa dos túbulos renais. Baseados nos achados os autores discutem os prováveis mecanismos patogenéticos. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1989-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28654Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 3 (1989); 139-145 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 3 (1989); 139-145 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 3 (1989); 139-145 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28654/30507Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessTafuri, Washington LuizMichalick, Marilena Suzan MarquesDias, MagnoGenaro, OdairLeite, Virginia Hora RiosBarbosa, Alfredo José AfonsoBambirra, Eduardo AlvesCosta, Carlos Alberto DaMelo, Maria NormaMayrink, Wilson2012-07-02T01:09:21Zoai:revistas.usp.br:article/28654Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:24.011834Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
Estudo, ao microscópio óptico e eletrônico, do rim de caes natural e experimentalmente infectados com Leishmania (Leishmania) chagasi
title Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
spellingShingle Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
Tafuri, Washington Luiz
Nefropatia parasitária
Leishmania (L.) chagasi
Calazar canino
title_short Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
title_full Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
title_fullStr Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
title_full_unstemmed Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
title_sort Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi
author Tafuri, Washington Luiz
author_facet Tafuri, Washington Luiz
Michalick, Marilena Suzan Marques
Dias, Magno
Genaro, Odair
Leite, Virginia Hora Rios
Barbosa, Alfredo José Afonso
Bambirra, Eduardo Alves
Costa, Carlos Alberto Da
Melo, Maria Norma
Mayrink, Wilson
author_role author
author2 Michalick, Marilena Suzan Marques
Dias, Magno
Genaro, Odair
Leite, Virginia Hora Rios
Barbosa, Alfredo José Afonso
Bambirra, Eduardo Alves
Costa, Carlos Alberto Da
Melo, Maria Norma
Mayrink, Wilson
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tafuri, Washington Luiz
Michalick, Marilena Suzan Marques
Dias, Magno
Genaro, Odair
Leite, Virginia Hora Rios
Barbosa, Alfredo José Afonso
Bambirra, Eduardo Alves
Costa, Carlos Alberto Da
Melo, Maria Norma
Mayrink, Wilson
dc.subject.por.fl_str_mv Nefropatia parasitária
Leishmania (L.) chagasi
Calazar canino
topic Nefropatia parasitária
Leishmania (L.) chagasi
Calazar canino
description Two naturally infected dogs (male and fema lei from Teófilo Otoni (MG Brazili were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO BR 70 BH46 Leishinania (Leishmanial chagasi strain, endo venous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulo nephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron dense deposits: (3) chronic interstitial nephritis with intense exudation of plasmocytes: (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.
publishDate 1989
dc.date.none.fl_str_mv 1989-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28654
url https://www.revistas.usp.br/rimtsp/article/view/28654
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28654/30507
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 3 (1989); 139-145
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 3 (1989); 139-145
Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 3 (1989); 139-145
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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