Cryopreservation of gametes - a hope for cancer patients

Detalhes bibliográficos
Autor(a) principal: Schuffner, Alessandro
Data de Publicação: 2004
Outros Autores: Ramos, Leandro, Stockler, Sandra, Hernandes, Rosana, Costa, Sérgio, Centa, Lidio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2044
Resumo: Two cases of successful pregnancy following semen banking before chemotherapy in cancer patients are described. In the first case, a 20 year-old patient had his semen cryopreserved after testicular cancer was diagnosed; 12 years later semen thawing was performed and used in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), resulting in a singleton pregnancy, uneventful prenatal with a term delivery. The second case, a 33 year-old patient had his semen cryopreserved before chemo-/radiotherapy for peripheral neuro-ectodermal tumor. These cases give support for semen banking, even for long period of time, especially men whose fertility in the future could be compromised by spermatogenesis suppression secondary to chemo- and radiotherapy administration. Using ICSI, a cryopreserved semen has a higher chance to cause pregnancy, especially in patients with little vital sperm. Cryopreserving of a single ejaculate previous to radio/chemotherapy could preserve fertility without compromising the oncological therapy. We can not forget recent successful achievements in the cryopreservation of ovarian tissue in cancer management of young females.
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spelling Cryopreservation of gametes - a hope for cancer patientsCriopreservação de gametas - uma esperança para pacientes com câncerNeoplasiasCriopreservaçãoFertilidadeFertilização in VitroGametasNeoplasmsCryopreservationFertilityin Vitro FertilizationGametesTwo cases of successful pregnancy following semen banking before chemotherapy in cancer patients are described. In the first case, a 20 year-old patient had his semen cryopreserved after testicular cancer was diagnosed; 12 years later semen thawing was performed and used in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), resulting in a singleton pregnancy, uneventful prenatal with a term delivery. The second case, a 33 year-old patient had his semen cryopreserved before chemo-/radiotherapy for peripheral neuro-ectodermal tumor. These cases give support for semen banking, even for long period of time, especially men whose fertility in the future could be compromised by spermatogenesis suppression secondary to chemo- and radiotherapy administration. Using ICSI, a cryopreserved semen has a higher chance to cause pregnancy, especially in patients with little vital sperm. Cryopreserving of a single ejaculate previous to radio/chemotherapy could preserve fertility without compromising the oncological therapy. We can not forget recent successful achievements in the cryopreservation of ovarian tissue in cancer management of young females.Relatam-se dois casos de gestação bem sucedida após o sêmen ser estocado antes da quimioterapia em pacientes com câncer. No primeiro caso, o paciente teve o sêmen congelado aos 20 anos de idade, ao ser diagnosticado câncer de testículo; 12 anos depois, foi descongelado e usado para fertilização in vitro/injeção intracitoplasmática de espermatozóide (FIV/ICSI), resultando em gravidez única, com nascimento a termo, sem complicações no pré-natal. No segundo caso, o paciente teve seu sêmen congelado aos 33 anos, antes da rádio-/quimioterapia para tumor neuro-ectodérmico primitivo do couro cabeludo. Estes casos dão sustentação à estocagem de sêmen, mesmo por um longo período, para homens cujo futuro de sua fertilidade possa ser comprometido através da supressão da espermatogênese secundária à administração de rádio e quimioterapia. O advento da ICSI veio aumentar a possibilidade de o sêmen criopreservado permitir uma gravidez, especialmente em pacientes com pequena quantidade de espermatozóides congelados. O armazenamento de um único ejaculado prévio ao início do tratamento com rádio-/quimioterapia pode preservar a fertilidade sem comprometimento do tratamento oncológico. Não podemos esquecer também de recentes sucessos na criopreservação de tecido ovariano na abordagem das jovens com câncer.INCA2004-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/204410.32635/2176-9745.RBC.2004v50n2.2044Revista Brasileira de Cancerologia; Vol. 50 No. 2 (2004): Apr./May/June; 117-120Revista Brasileira de Cancerologia; Vol. 50 Núm. 2 (2004): abr./mayo/jun.; 117-120Revista Brasileira de Cancerologia; v. 50 n. 2 (2004): abr./maio/jun.; 117-1202176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2044/1262Schuffner, Alessandro Ramos, Leandro Stockler, Sandra Hernandes, Rosana Costa, Sérgio Centa, Lidio info:eu-repo/semantics/openAccess2021-11-29T20:33:20Zoai:rbc.inca.gov.br:article/2044Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:33:20Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Cryopreservation of gametes - a hope for cancer patients
Criopreservação de gametas - uma esperança para pacientes com câncer
title Cryopreservation of gametes - a hope for cancer patients
spellingShingle Cryopreservation of gametes - a hope for cancer patients
Schuffner, Alessandro
Neoplasias
Criopreservação
Fertilidade
Fertilização in Vitro
Gametas
Neoplasms
Cryopreservation
Fertility
in Vitro Fertilization
Gametes
title_short Cryopreservation of gametes - a hope for cancer patients
title_full Cryopreservation of gametes - a hope for cancer patients
title_fullStr Cryopreservation of gametes - a hope for cancer patients
title_full_unstemmed Cryopreservation of gametes - a hope for cancer patients
title_sort Cryopreservation of gametes - a hope for cancer patients
author Schuffner, Alessandro
author_facet Schuffner, Alessandro
Ramos, Leandro
Stockler, Sandra
Hernandes, Rosana
Costa, Sérgio
Centa, Lidio
author_role author
author2 Ramos, Leandro
Stockler, Sandra
Hernandes, Rosana
Costa, Sérgio
Centa, Lidio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Schuffner, Alessandro
Ramos, Leandro
Stockler, Sandra
Hernandes, Rosana
Costa, Sérgio
Centa, Lidio
dc.subject.por.fl_str_mv Neoplasias
Criopreservação
Fertilidade
Fertilização in Vitro
Gametas
Neoplasms
Cryopreservation
Fertility
in Vitro Fertilization
Gametes
topic Neoplasias
Criopreservação
Fertilidade
Fertilização in Vitro
Gametas
Neoplasms
Cryopreservation
Fertility
in Vitro Fertilization
Gametes
description Two cases of successful pregnancy following semen banking before chemotherapy in cancer patients are described. In the first case, a 20 year-old patient had his semen cryopreserved after testicular cancer was diagnosed; 12 years later semen thawing was performed and used in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), resulting in a singleton pregnancy, uneventful prenatal with a term delivery. The second case, a 33 year-old patient had his semen cryopreserved before chemo-/radiotherapy for peripheral neuro-ectodermal tumor. These cases give support for semen banking, even for long period of time, especially men whose fertility in the future could be compromised by spermatogenesis suppression secondary to chemo- and radiotherapy administration. Using ICSI, a cryopreserved semen has a higher chance to cause pregnancy, especially in patients with little vital sperm. Cryopreserving of a single ejaculate previous to radio/chemotherapy could preserve fertility without compromising the oncological therapy. We can not forget recent successful achievements in the cryopreservation of ovarian tissue in cancer management of young females.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Relato de Caso
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2044
10.32635/2176-9745.RBC.2004v50n2.2044
url https://rbc.inca.gov.br/index.php/revista/article/view/2044
identifier_str_mv 10.32635/2176-9745.RBC.2004v50n2.2044
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2044/1262
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 50 No. 2 (2004): Apr./May/June; 117-120
Revista Brasileira de Cancerologia; Vol. 50 Núm. 2 (2004): abr./mayo/jun.; 117-120
Revista Brasileira de Cancerologia; v. 50 n. 2 (2004): abr./maio/jun.; 117-120
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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