Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review

Detalhes bibliográficos
Autor(a) principal: Feitoza, Lais Quelen
Data de Publicação: 2021
Outros Autores: Terra, Fábio de Souza, Grasselli, Cristiane da Silva Marciano
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1114
Resumo: Introduction: The epidemiological and nutritional transitions have been contributing for the exponential growth of cancer. Thus, in order to enhance the activity of antineoplastic drugs, the number of studies using medicinal plants for cancer treatment has increased. Objective: To identify medicinal plants and compounds with possible action in the cancer treatment process. Method: An integrative review was carried out. For the bibliographic search, the descriptors “neoplasms” and “medicinal plants” and the qualifier “treatment” for the word cancer were used, specifying it. The articles were surveyed in the following databases: Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (LILACS) and Medical Literature Analysis and Retrieval System on-line (MEDLINE) from the PubMed. Results: The search and application of the inclusion and exclusion criteria resulted in the selection of 93 articles. The main characteristics of the studies included were in vitro assays, with breast cancer cell line and published in English. It was possible to identify six compounds that stood out due to their pro-apoptotic activity in various types of cancer such as curcumin, epicatechin, lupeol, caffeic acid, ursolic acid and berberine. Conclusion: The present work offers inputs so that future studies can associate the use of compounds present in medicinal plants with conventional treatment, in order to improve the prognosis of cancer patients.
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spelling Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative ReviewPlantas Medicinales y sus Compuestos con Potencial Terapéutico en el Tratamiento del Cáncer: Revisión IntegradoraPlantas Medicinais e seus Compostos com Potencial Terapêutico no Tratamento do Câncer: Revisão IntegrativaNeoplasias/terapiaPlantas Medicinais/químicaTerapêuticaTerapias ComplementaresNeoplasms/therapyPlants, Medicinal/chemistryTherapeuticsComplementary TherapiesNeoplasias/terapiaPlantas Medicinales/químicaTerapéuticaTerapias ComplementariasIntroduction: The epidemiological and nutritional transitions have been contributing for the exponential growth of cancer. Thus, in order to enhance the activity of antineoplastic drugs, the number of studies using medicinal plants for cancer treatment has increased. Objective: To identify medicinal plants and compounds with possible action in the cancer treatment process. Method: An integrative review was carried out. For the bibliographic search, the descriptors “neoplasms” and “medicinal plants” and the qualifier “treatment” for the word cancer were used, specifying it. The articles were surveyed in the following databases: Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (LILACS) and Medical Literature Analysis and Retrieval System on-line (MEDLINE) from the PubMed. Results: The search and application of the inclusion and exclusion criteria resulted in the selection of 93 articles. The main characteristics of the studies included were in vitro assays, with breast cancer cell line and published in English. It was possible to identify six compounds that stood out due to their pro-apoptotic activity in various types of cancer such as curcumin, epicatechin, lupeol, caffeic acid, ursolic acid and berberine. Conclusion: The present work offers inputs so that future studies can associate the use of compounds present in medicinal plants with conventional treatment, in order to improve the prognosis of cancer patients.Introducción: Las transiciones epidemiológica y nutricional han contribuido al crecimiento exponencial del cáncer. Por lo tanto, para mejorar la actividad de los fármacos antineoplásicos utilizados para tratar la enfermedad, há aumentado el número de estudios que utilizan plantas medicinales para este propósito. Objetivo: Identificar plantas medicinales y compuestos con posible acción en el proceso de tratamiento del cáncer. Método: Se realizó una revisión integradora, utilizando los términos de búsqueda validados y utilizados: “neoplasias” y “plantas medicinales”. El calificador “tratamiento” se usó para la palabra cáncer, especificándolo. Los artículos fueron encuestados en las siguientes bases de datos: Biblioteca Científica Electrónica en Línea (SciELO), Literatura Latinoamericana y Caribeña en Ciencias de la Salud (LILACS) y Sistema de Análisis y Recuperación de Literatura Médica en Línea (MEDLINE) vía PubMed. Resultados: La búsqueda y la aplicación de los criterios de inclusión y exclusión dieron como resultado la selección de 93 artículos. Las características principales de los estudios incluidos fueron ensayos in vitro, con linaje celular de cáncer de mama y publicados en inglés. En relación con los estudios, fue posible identificar seis compuestos que se destacaron por su actividad contra diferentes tipos de cáncer: curcumina, epicatequina, lupeol, ácido cafeico, ácido ursólico y berberina, induciendo la apoptosis por varios mecanismos. Conclusión: El presente trabajo, nos permite ofrecer subsidio para que la investigación futura pueda asociar el uso de compuestos presentes en plantas medicinales con el tratamiento convencional, para mejorar el pronóstico de los pacientes con cáncer.Introdução: As transições epidemiológica e nutricional têm contribuído para o crescimento exponencial do câncer. Assim, com o intuito de potencializar a atividade das drogas antineoplásicas, aumentou o número de estudos utilizando plantas medicinais para tratamento do câncer. Objetivo: Identificar as plantas medicinais e os compostos com possível ação no processo de tratamento do câncer. Método: Foi realizada uma revisão integrativa. Para a busca bibliográfica, foram utilizados os descritores “neoplasias” e “plantas medicinais” e o qualificador “tratamento” para a palavra câncer, especificando-a. O levantamento dos artigos foi feito nas seguintes bases de dados: Scientific Electronic Library OnLine (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Medical Literature Analysis and Retrieval Sistem Online (MEDLINE) via PubMed. Resultados: A busca e a aplicação dos critérios de inclusão e exclusão resultaram na seleção de 93 artigos. As principais características dos estudos incluídos eram ensaios in vitro, com a linhagem de células de câncer de mama e publicados em inglês. Foi possível identificar seis compostos que se destacaram em razão da sua atividade pró-apoptótica em vários tipos de câncer, a exemplo da curcumina, da epicatequina, do lupeol, do ácido cafeico, do ácido ursólico e da berberina. Conclusão: O presente trabalho oferece subsídios para que pesquisas futuras possam associar a utilização de compostos presentes em plantas medicinais ao tratamento convencional, com o intuito de melhorar o prognóstico de pacientes oncológicos.INCA2021-01-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/111410.32635/2176-9745.RBC.2021v67n1.1114Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-031114Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-031114Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-0311142176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1114/820https://rbc.inca.gov.br/index.php/revista/article/view/1114/1060Copyright (c) 2021 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessFeitoza, Lais Quelen Terra, Fábio de Souza Grasselli, Cristiane da Silva Marciano2021-11-29T18:29:26Zoai:rbc.inca.gov.br:article/1114Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T18:29:26Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
Plantas Medicinales y sus Compuestos con Potencial Terapéutico en el Tratamiento del Cáncer: Revisión Integradora
Plantas Medicinais e seus Compostos com Potencial Terapêutico no Tratamento do Câncer: Revisão Integrativa
title Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
spellingShingle Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
Feitoza, Lais Quelen
Neoplasias/terapia
Plantas Medicinais/química
Terapêutica
Terapias Complementares
Neoplasms/therapy
Plants, Medicinal/chemistry
Therapeutics
Complementary Therapies
Neoplasias/terapia
Plantas Medicinales/química
Terapéutica
Terapias Complementarias
title_short Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
title_full Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
title_fullStr Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
title_full_unstemmed Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
title_sort Medicinal Plants and their Compounds with Therapeutic Potential in the Treatment of Cancer: an Integrative Review
author Feitoza, Lais Quelen
author_facet Feitoza, Lais Quelen
Terra, Fábio de Souza
Grasselli, Cristiane da Silva Marciano
author_role author
author2 Terra, Fábio de Souza
Grasselli, Cristiane da Silva Marciano
author2_role author
author
dc.contributor.author.fl_str_mv Feitoza, Lais Quelen
Terra, Fábio de Souza
Grasselli, Cristiane da Silva Marciano
dc.subject.por.fl_str_mv Neoplasias/terapia
Plantas Medicinais/química
Terapêutica
Terapias Complementares
Neoplasms/therapy
Plants, Medicinal/chemistry
Therapeutics
Complementary Therapies
Neoplasias/terapia
Plantas Medicinales/química
Terapéutica
Terapias Complementarias
topic Neoplasias/terapia
Plantas Medicinais/química
Terapêutica
Terapias Complementares
Neoplasms/therapy
Plants, Medicinal/chemistry
Therapeutics
Complementary Therapies
Neoplasias/terapia
Plantas Medicinales/química
Terapéutica
Terapias Complementarias
description Introduction: The epidemiological and nutritional transitions have been contributing for the exponential growth of cancer. Thus, in order to enhance the activity of antineoplastic drugs, the number of studies using medicinal plants for cancer treatment has increased. Objective: To identify medicinal plants and compounds with possible action in the cancer treatment process. Method: An integrative review was carried out. For the bibliographic search, the descriptors “neoplasms” and “medicinal plants” and the qualifier “treatment” for the word cancer were used, specifying it. The articles were surveyed in the following databases: Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (LILACS) and Medical Literature Analysis and Retrieval System on-line (MEDLINE) from the PubMed. Results: The search and application of the inclusion and exclusion criteria resulted in the selection of 93 articles. The main characteristics of the studies included were in vitro assays, with breast cancer cell line and published in English. It was possible to identify six compounds that stood out due to their pro-apoptotic activity in various types of cancer such as curcumin, epicatechin, lupeol, caffeic acid, ursolic acid and berberine. Conclusion: The present work offers inputs so that future studies can associate the use of compounds present in medicinal plants with conventional treatment, in order to improve the prognosis of cancer patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1114
10.32635/2176-9745.RBC.2021v67n1.1114
url https://rbc.inca.gov.br/index.php/revista/article/view/1114
identifier_str_mv 10.32635/2176-9745.RBC.2021v67n1.1114
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1114/820
https://rbc.inca.gov.br/index.php/revista/article/view/1114/1060
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 67 No. 1 (2021): Jan./Feb./Mar.; e-031114
Revista Brasileira de Cancerologia; Vol. 67 Núm. 1 (2021): ene./feb./mar.; e-031114
Revista Brasileira de Cancerologia; v. 67 n. 1 (2021): jan./fev./mar.; e-031114
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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