Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review

Detalhes bibliográficos
Autor(a) principal: Bonan, Paulo Rogério Ferreti
Data de Publicação: 2005
Outros Autores: Lopes, Márcio Ajudarte, Alves, Fábio de Abreu, Almeida, Oslei Paes de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1951
Resumo: The oral mucositis is a main side effect of radiotherapy on head and neck, initiating two weeks after the beginning of the treatment. It is characterized by sensation of local burning to intense pain, leading in several cases, to the interruption of the treatment. The purpose of this work is to review the main published studies that discusse the clinical, biological and histopathological features of oral mucositis induced by radiation therapy and to describe the main approches recommended to prevent or to treat it. Although the clinical features of mucositis are intensively described in the literature, few studies address the histopatological alterations in oral mucositis and only recently, its biological processes have been investigated. The biological mechanisms involved in the radiation tissue damage have been only recently discussed and there is no consensus among treatment modalities. Yet, the progressive knowledge in the histopathology and biological characteristics of oral mucositis probably will lead to more effective in prevention and control strategies.
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spelling Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature reviewAspectos clínicos, biológicos, histopatológicos e tratamentos propostos para a mucosite oral induzida por radioterapia: revisão da literaturaRadioterapiaMucositeNeoplasias bucaisEfeitos adversosRadiotherapyMucositisMouth neoplasmsAdverse effectsThe oral mucositis is a main side effect of radiotherapy on head and neck, initiating two weeks after the beginning of the treatment. It is characterized by sensation of local burning to intense pain, leading in several cases, to the interruption of the treatment. The purpose of this work is to review the main published studies that discusse the clinical, biological and histopathological features of oral mucositis induced by radiation therapy and to describe the main approches recommended to prevent or to treat it. Although the clinical features of mucositis are intensively described in the literature, few studies address the histopatological alterations in oral mucositis and only recently, its biological processes have been investigated. The biological mechanisms involved in the radiation tissue damage have been only recently discussed and there is no consensus among treatment modalities. Yet, the progressive knowledge in the histopathology and biological characteristics of oral mucositis probably will lead to more effective in prevention and control strategies.A mucosite oral é um dos principais efeitos colaterais agudos induzidos pelo tratamento radioterápico em cabeça e pescoço, surgindo a partir da segunda semana de tratamento e é caracterizada por ardência bucal até sintomatologia dolorosa intensa exigindo em algumas situações a interrupção do tratamento radioterápico. O objetivo desse trabalho foi rever os principais trabalhos publicados que discutem as características clínicas, histopatológicas e tratamentos propostos para a mucosite oral induzida por radioterapia. Poucos estudos descreveram os aspectos histopatológicos da mucosite oral e apenas recentemente os mecanismos biológicos começaram a ser desvendados. Embora diversas modalidades terapêuticas sejam indicadas para a prevenção e tratamento da mucosite oral, não existe consenso sobre o tratamento mais indicado. A melhor compreensão dos mecanismos biológicos e da histopatologia provavelmente contribuirá para a indicação de terapias eficazes na prevenção e manejo da mucosite oral.INCA2005-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/195110.32635/2176-9745.RBC.2005v51n3.1951Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 235-242Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 235-242Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 235-2422176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1951/1185Bonan, Paulo Rogério Ferreti Lopes, Márcio Ajudarte Alves, Fábio de Abreu Almeida, Oslei Paes de info:eu-repo/semantics/openAccess2021-11-29T20:29:50Zoai:rbc.inca.gov.br:article/1951Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:29:50Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
Aspectos clínicos, biológicos, histopatológicos e tratamentos propostos para a mucosite oral induzida por radioterapia: revisão da literatura
title Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
spellingShingle Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
Bonan, Paulo Rogério Ferreti
Radioterapia
Mucosite
Neoplasias bucais
Efeitos adversos
Radiotherapy
Mucositis
Mouth neoplasms
Adverse effects
title_short Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
title_full Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
title_fullStr Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
title_full_unstemmed Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
title_sort Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
author Bonan, Paulo Rogério Ferreti
author_facet Bonan, Paulo Rogério Ferreti
Lopes, Márcio Ajudarte
Alves, Fábio de Abreu
Almeida, Oslei Paes de
author_role author
author2 Lopes, Márcio Ajudarte
Alves, Fábio de Abreu
Almeida, Oslei Paes de
author2_role author
author
author
dc.contributor.author.fl_str_mv Bonan, Paulo Rogério Ferreti
Lopes, Márcio Ajudarte
Alves, Fábio de Abreu
Almeida, Oslei Paes de
dc.subject.por.fl_str_mv Radioterapia
Mucosite
Neoplasias bucais
Efeitos adversos
Radiotherapy
Mucositis
Mouth neoplasms
Adverse effects
topic Radioterapia
Mucosite
Neoplasias bucais
Efeitos adversos
Radiotherapy
Mucositis
Mouth neoplasms
Adverse effects
description The oral mucositis is a main side effect of radiotherapy on head and neck, initiating two weeks after the beginning of the treatment. It is characterized by sensation of local burning to intense pain, leading in several cases, to the interruption of the treatment. The purpose of this work is to review the main published studies that discusse the clinical, biological and histopathological features of oral mucositis induced by radiation therapy and to describe the main approches recommended to prevent or to treat it. Although the clinical features of mucositis are intensively described in the literature, few studies address the histopatological alterations in oral mucositis and only recently, its biological processes have been investigated. The biological mechanisms involved in the radiation tissue damage have been only recently discussed and there is no consensus among treatment modalities. Yet, the progressive knowledge in the histopathology and biological characteristics of oral mucositis probably will lead to more effective in prevention and control strategies.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1951
10.32635/2176-9745.RBC.2005v51n3.1951
url https://rbc.inca.gov.br/index.php/revista/article/view/1951
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n3.1951
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1951/1185
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 235-242
Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 235-242
Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 235-242
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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