Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/1951 |
Resumo: | The oral mucositis is a main side effect of radiotherapy on head and neck, initiating two weeks after the beginning of the treatment. It is characterized by sensation of local burning to intense pain, leading in several cases, to the interruption of the treatment. The purpose of this work is to review the main published studies that discusse the clinical, biological and histopathological features of oral mucositis induced by radiation therapy and to describe the main approches recommended to prevent or to treat it. Although the clinical features of mucositis are intensively described in the literature, few studies address the histopatological alterations in oral mucositis and only recently, its biological processes have been investigated. The biological mechanisms involved in the radiation tissue damage have been only recently discussed and there is no consensus among treatment modalities. Yet, the progressive knowledge in the histopathology and biological characteristics of oral mucositis probably will lead to more effective in prevention and control strategies. |
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Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature reviewAspectos clínicos, biológicos, histopatológicos e tratamentos propostos para a mucosite oral induzida por radioterapia: revisão da literaturaRadioterapiaMucositeNeoplasias bucaisEfeitos adversosRadiotherapyMucositisMouth neoplasmsAdverse effectsThe oral mucositis is a main side effect of radiotherapy on head and neck, initiating two weeks after the beginning of the treatment. It is characterized by sensation of local burning to intense pain, leading in several cases, to the interruption of the treatment. The purpose of this work is to review the main published studies that discusse the clinical, biological and histopathological features of oral mucositis induced by radiation therapy and to describe the main approches recommended to prevent or to treat it. Although the clinical features of mucositis are intensively described in the literature, few studies address the histopatological alterations in oral mucositis and only recently, its biological processes have been investigated. The biological mechanisms involved in the radiation tissue damage have been only recently discussed and there is no consensus among treatment modalities. Yet, the progressive knowledge in the histopathology and biological characteristics of oral mucositis probably will lead to more effective in prevention and control strategies.A mucosite oral é um dos principais efeitos colaterais agudos induzidos pelo tratamento radioterápico em cabeça e pescoço, surgindo a partir da segunda semana de tratamento e é caracterizada por ardência bucal até sintomatologia dolorosa intensa exigindo em algumas situações a interrupção do tratamento radioterápico. O objetivo desse trabalho foi rever os principais trabalhos publicados que discutem as características clínicas, histopatológicas e tratamentos propostos para a mucosite oral induzida por radioterapia. Poucos estudos descreveram os aspectos histopatológicos da mucosite oral e apenas recentemente os mecanismos biológicos começaram a ser desvendados. Embora diversas modalidades terapêuticas sejam indicadas para a prevenção e tratamento da mucosite oral, não existe consenso sobre o tratamento mais indicado. A melhor compreensão dos mecanismos biológicos e da histopatologia provavelmente contribuirá para a indicação de terapias eficazes na prevenção e manejo da mucosite oral.INCA2005-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/195110.32635/2176-9745.RBC.2005v51n3.1951Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 235-242Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 235-242Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 235-2422176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1951/1185Bonan, Paulo Rogério Ferreti Lopes, Márcio Ajudarte Alves, Fábio de Abreu Almeida, Oslei Paes de info:eu-repo/semantics/openAccess2021-11-29T20:29:50Zoai:rbc.inca.gov.br:article/1951Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:29:50Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review Aspectos clínicos, biológicos, histopatológicos e tratamentos propostos para a mucosite oral induzida por radioterapia: revisão da literatura |
title |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review |
spellingShingle |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review Bonan, Paulo Rogério Ferreti Radioterapia Mucosite Neoplasias bucais Efeitos adversos Radiotherapy Mucositis Mouth neoplasms Adverse effects |
title_short |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review |
title_full |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review |
title_fullStr |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review |
title_full_unstemmed |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review |
title_sort |
Clinical, biological, histological features and treatment of oral mucositis induced by radiation therapy: a literature review |
author |
Bonan, Paulo Rogério Ferreti |
author_facet |
Bonan, Paulo Rogério Ferreti Lopes, Márcio Ajudarte Alves, Fábio de Abreu Almeida, Oslei Paes de |
author_role |
author |
author2 |
Lopes, Márcio Ajudarte Alves, Fábio de Abreu Almeida, Oslei Paes de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Bonan, Paulo Rogério Ferreti Lopes, Márcio Ajudarte Alves, Fábio de Abreu Almeida, Oslei Paes de |
dc.subject.por.fl_str_mv |
Radioterapia Mucosite Neoplasias bucais Efeitos adversos Radiotherapy Mucositis Mouth neoplasms Adverse effects |
topic |
Radioterapia Mucosite Neoplasias bucais Efeitos adversos Radiotherapy Mucositis Mouth neoplasms Adverse effects |
description |
The oral mucositis is a main side effect of radiotherapy on head and neck, initiating two weeks after the beginning of the treatment. It is characterized by sensation of local burning to intense pain, leading in several cases, to the interruption of the treatment. The purpose of this work is to review the main published studies that discusse the clinical, biological and histopathological features of oral mucositis induced by radiation therapy and to describe the main approches recommended to prevent or to treat it. Although the clinical features of mucositis are intensively described in the literature, few studies address the histopatological alterations in oral mucositis and only recently, its biological processes have been investigated. The biological mechanisms involved in the radiation tissue damage have been only recently discussed and there is no consensus among treatment modalities. Yet, the progressive knowledge in the histopathology and biological characteristics of oral mucositis probably will lead to more effective in prevention and control strategies. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-09-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1951 10.32635/2176-9745.RBC.2005v51n3.1951 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/1951 |
identifier_str_mv |
10.32635/2176-9745.RBC.2005v51n3.1951 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1951/1185 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 51 No. 3 (2005): July/Aug./Sept.; 235-242 Revista Brasileira de Cancerologia; Vol. 51 Núm. 3 (2005): jul./ago./sept.; 235-242 Revista Brasileira de Cancerologia; v. 51 n. 3 (2005): jul./ago./set.; 235-242 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042248857157632 |