The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas

Detalhes bibliográficos
Autor(a) principal: Barbosa, Edison Mantovani
Data de Publicação: 2022
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2797
Resumo: This stucly shows the content analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variable in 69 specimens of breast carcinomas. A significant association between DNA ploidy and the tumor size, estrogen and progesterone receptors, was noticed. Also another association was identified between the percentage of S phase and menstrual status, estrogen receptors, and axillary node metastases. Tumors classified as DNA aneuploid, with Sphase higger than 7.15 presented more metastasis and smaller survival compared to DNA diploid tumors and S phase lower than 7.15. According to the prognostic point of view, the importance of the DNA study was demonstrated privately for the axillary node negative group.
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spelling The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomasAnálise da porcentagem da DNA ploidia e de células em fase S, determinada por citometria de fluxo e por outras variáveis prognosticas em carcinomas primários de mamaCâncer de MamaCitometria de FluxoProliferação CelularConteúdo de DNAPrognósticoBreast CancerFlow CytometryCell ProliferationDNA ContentePrognosisThis stucly shows the content analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variable in 69 specimens of breast carcinomas. A significant association between DNA ploidy and the tumor size, estrogen and progesterone receptors, was noticed. Also another association was identified between the percentage of S phase and menstrual status, estrogen receptors, and axillary node metastases. Tumors classified as DNA aneuploid, with Sphase higger than 7.15 presented more metastasis and smaller survival compared to DNA diploid tumors and S phase lower than 7.15. According to the prognostic point of view, the importance of the DNA study was demonstrated privately for the axillary node negative group.Analisaram-se a DNA ploidia e a porcentagem de células em fase S, determinadas por citometria de fluxo, em biópsias de 69 carcinomas mamários. Outras variáveis prognosticas foram estudadas: 1. clínicas (raça, idade, estado menstruai, estadiamento, tamanho do tumor e a avaliação dos linfonodos axilares); 2. histológicas (comprometimento metastático dos linfonodos axilares, embolização de células neoplásicas em vasos linfáticos e sanguíneos, grau de diferenciação histológica, número de mitoses e necrose tumoral); 3. Bioquímicas (receptores de estradiol e progesterona). Cotejaram-se estas variáveis com o estudo da DNA ploidia e porcentagem de fase S. Notou-se haver uma associação significativa entre a DNA diploidia em pacientes com idade acima de 50 anos, tumores de tamanho ou igual a 2,0 cm, receptores de estradiol e receptores de progesterona. Observou-se também uma associação significativa entre a porcentagem de fase S >7,15 e pacientes na pré-menopausa, receptores de estradiol negativo e comprometimento metastático linfonodal. Constatou-se que as pacientes com tumores classificados como DNA aneuplóides, com fase S maior que 7,15, apresentaram metástases mais freqüentes e sobrevida menor que aquelas com tumores DNA diplóides e fase S menor que 7,15. Sob o ponto de vista do prognóstico pode-se constatar a importância do estudo do DNA, particularmente para o grupo pNO. Verificou-se a viabilidade de esta técnica ser realizada em nossa rotina para o estudo prognóstico do câncer de mama.INCA2022-09-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/279710.32635/2176-9745.RBC.1998v44n1.2797Revista Brasileira de Cancerologia; Vol. 44 No. 1 (1998): Jan./Feb./Mar.; 25-34Revista Brasileira de Cancerologia; Vol. 44 Núm. 1 (1998): ene./feb./mar.; 25-34Revista Brasileira de Cancerologia; v. 44 n. 1 (1998): jan./fev./mar.; 25-342176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2797/1675https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarbosa, Edison Mantovani 2023-01-18T15:09:08Zoai:rbc.inca.gov.br:article/2797Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T15:09:08Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
Análise da porcentagem da DNA ploidia e de células em fase S, determinada por citometria de fluxo e por outras variáveis prognosticas em carcinomas primários de mama
title The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
spellingShingle The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
Barbosa, Edison Mantovani
Câncer de Mama
Citometria de Fluxo
Proliferação Celular
Conteúdo de DNA
Prognóstico
Breast Cancer
Flow Cytometry
Cell Proliferation
DNA Contente
Prognosis
title_short The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
title_full The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
title_fullStr The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
title_full_unstemmed The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
title_sort The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
author Barbosa, Edison Mantovani
author_facet Barbosa, Edison Mantovani
author_role author
dc.contributor.author.fl_str_mv Barbosa, Edison Mantovani
dc.subject.por.fl_str_mv Câncer de Mama
Citometria de Fluxo
Proliferação Celular
Conteúdo de DNA
Prognóstico
Breast Cancer
Flow Cytometry
Cell Proliferation
DNA Contente
Prognosis
topic Câncer de Mama
Citometria de Fluxo
Proliferação Celular
Conteúdo de DNA
Prognóstico
Breast Cancer
Flow Cytometry
Cell Proliferation
DNA Contente
Prognosis
description This stucly shows the content analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variable in 69 specimens of breast carcinomas. A significant association between DNA ploidy and the tumor size, estrogen and progesterone receptors, was noticed. Also another association was identified between the percentage of S phase and menstrual status, estrogen receptors, and axillary node metastases. Tumors classified as DNA aneuploid, with Sphase higger than 7.15 presented more metastasis and smaller survival compared to DNA diploid tumors and S phase lower than 7.15. According to the prognostic point of view, the importance of the DNA study was demonstrated privately for the axillary node negative group.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2797
10.32635/2176-9745.RBC.1998v44n1.2797
url https://rbc.inca.gov.br/index.php/revista/article/view/2797
identifier_str_mv 10.32635/2176-9745.RBC.1998v44n1.2797
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2797/1675
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 44 No. 1 (1998): Jan./Feb./Mar.; 25-34
Revista Brasileira de Cancerologia; Vol. 44 Núm. 1 (1998): ene./feb./mar.; 25-34
Revista Brasileira de Cancerologia; v. 44 n. 1 (1998): jan./fev./mar.; 25-34
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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