Quimioterapia Primária em Carcinoma Avançado de Cabeça e Pescoço

• Autor(a) principal: Oliveira Filho, Juvenal Antunes de
• Data de Publicação: 2023
• Outros Autores: Cunha, Fernando Medina da, Schlupp, Werner Roedel, Chiminazzo Junior, Honório, Cunha, Ludmilla Medina da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Brasileira de Cancerologia (Online)
• Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3359
• topic: Quimioterapia Primária; Câncer de Cabeça e Pescoço; Primary Chemotherapy; Head and Neck Cancer

The results of a pilot study of primary chemotherapy for outpatient use of Cisplatin and Bleomycin in advanced head and neck cancer are discussed. After 2 cycles of chemotherapy patients were taken to radiotherapy. Of 46 patients initially treated with chemotherapy 34,7% had objective response with a median survival of 28 months, the median survival being 13 months for the non-responders (p = 0.0031). After radiotherapy the objective response was 63,6%, with a median survival of 28 months for responders and 8 months for non-responders (p = 0,027). It was concluded that epidermoid carcinomas of head and neck are sensitive to chemotherapy as primary treatment and prospective and randomized studies are needed.