Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/4012 |
Resumo: | Basing themselves on certain existing relations between cancer and diabetes, the authors attempted to combine in an adequate manner the beneficent action of phospholipids with that of insulin. The experimental results were surprisingly favourable for it could be stated that the growth of the transplanted Yoshida sarcoma was inhibited completely in not less than 60 per cent of the treated animais, whereas in the remaining 40 per cent the growth was reduced to less than half. Alloxan, although in a lesser degree, showed similar favourable results when combined with phospholipids. |
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Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and AlloxanEfeitos Antimetastáticos e Citostáticos dos Fosfolipídios Associados a Insulina e AloxanaNeoplasias/etiologiaNeoplasias/terapiaFosfolipídeos/uso terapêuticoInsulinaAloxanoSarcoma de YoshidaNeoplasms/etiologyNeoplasms/therapyPhospholipids/therapeutic useInsulinAlloxanSarcoma, YoshidaNeoplasias/etiologíaNeoplasias/terapiaFosfolípidos/uso terapêuticoInsulinaAloxanoSarcoma de YoshidaBasing themselves on certain existing relations between cancer and diabetes, the authors attempted to combine in an adequate manner the beneficent action of phospholipids with that of insulin. The experimental results were surprisingly favourable for it could be stated that the growth of the transplanted Yoshida sarcoma was inhibited completely in not less than 60 per cent of the treated animais, whereas in the remaining 40 per cent the growth was reduced to less than half. Alloxan, although in a lesser degree, showed similar favourable results when combined with phospholipids.Baseando-se em certas relações existentes entre a etiologia do câncer e a do diabetes, os autores procuram combinar de uma maneira adequada a ação benéfica dos fosfolipídeos com a da insulina. Os resultados experimentais foram surpreendentes, pois foi conseguida uma inibição total do crescimento do sarcoma de Yoshida em nada menos que 60% dos animais tratados, enquanto nos 40% restantes foi observado um retardamento do crescimento do tumor de 50% em relação ao controle. Aloxana, associada aos fosfolipídeos demonstrou, embora em menor escala, também um efeito favorável.INCA2023-08-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/401210.32635/2176-9745.RBC.1968v24n38.4012Revista Brasileira de Cancerologia; Vol. 24 No. 38 (1968): Oct.; 83-87Revista Brasileira de Cancerologia; Vol. 24 Núm. 38 (1968): oct.; 83-87Revista Brasileira de Cancerologia; v. 24 n. 38 (1968): out.; 83-872176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/4012/2806Copyright (c) 2023 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAltman, Reinout F. A.Spoladore, Luiz G.2023-08-18T19:50:50Zoai:rbc.inca.gov.br:article/4012Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-18T19:50:50Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan Efeitos Antimetastáticos e Citostáticos dos Fosfolipídios Associados a Insulina e Aloxana |
title |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan |
spellingShingle |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan Altman, Reinout F. A. Neoplasias/etiologia Neoplasias/terapia Fosfolipídeos/uso terapêutico Insulina Aloxano Sarcoma de Yoshida Neoplasms/etiology Neoplasms/therapy Phospholipids/therapeutic use Insulin Alloxan Sarcoma, Yoshida Neoplasias/etiología Neoplasias/terapia Fosfolípidos/uso terapêutico Insulina Aloxano Sarcoma de Yoshida |
title_short |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan |
title_full |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan |
title_fullStr |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan |
title_full_unstemmed |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan |
title_sort |
Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan |
author |
Altman, Reinout F. A. |
author_facet |
Altman, Reinout F. A. Spoladore, Luiz G. |
author_role |
author |
author2 |
Spoladore, Luiz G. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Altman, Reinout F. A. Spoladore, Luiz G. |
dc.subject.por.fl_str_mv |
Neoplasias/etiologia Neoplasias/terapia Fosfolipídeos/uso terapêutico Insulina Aloxano Sarcoma de Yoshida Neoplasms/etiology Neoplasms/therapy Phospholipids/therapeutic use Insulin Alloxan Sarcoma, Yoshida Neoplasias/etiología Neoplasias/terapia Fosfolípidos/uso terapêutico Insulina Aloxano Sarcoma de Yoshida |
topic |
Neoplasias/etiologia Neoplasias/terapia Fosfolipídeos/uso terapêutico Insulina Aloxano Sarcoma de Yoshida Neoplasms/etiology Neoplasms/therapy Phospholipids/therapeutic use Insulin Alloxan Sarcoma, Yoshida Neoplasias/etiología Neoplasias/terapia Fosfolípidos/uso terapêutico Insulina Aloxano Sarcoma de Yoshida |
description |
Basing themselves on certain existing relations between cancer and diabetes, the authors attempted to combine in an adequate manner the beneficent action of phospholipids with that of insulin. The experimental results were surprisingly favourable for it could be stated that the growth of the transplanted Yoshida sarcoma was inhibited completely in not less than 60 per cent of the treated animais, whereas in the remaining 40 per cent the growth was reduced to less than half. Alloxan, although in a lesser degree, showed similar favourable results when combined with phospholipids. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/4012 10.32635/2176-9745.RBC.1968v24n38.4012 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/4012 |
identifier_str_mv |
10.32635/2176-9745.RBC.1968v24n38.4012 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/4012/2806 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 24 No. 38 (1968): Oct.; 83-87 Revista Brasileira de Cancerologia; Vol. 24 Núm. 38 (1968): oct.; 83-87 Revista Brasileira de Cancerologia; v. 24 n. 38 (1968): out.; 83-87 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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