Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan

Detalhes bibliográficos
Autor(a) principal: Altman, Reinout F. A.
Data de Publicação: 2023
Outros Autores: Spoladore, Luiz G.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/4012
Resumo: Basing themselves on certain existing relations between cancer and diabetes, the authors attempted to combine in an adequate manner the beneficent action of phospholipids with that of insulin. The experimental results were surprisingly favourable for it could be stated that the growth of the transplanted Yoshida sarcoma was inhibited completely in not less than 60 per cent of the treated animais, whereas in the remaining 40 per cent the growth was reduced to less than half. Alloxan, although in a lesser degree, showed similar favourable results when combined with phospholipids.
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spelling Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and AlloxanEfeitos Antimetastáticos e Citostáticos dos Fosfolipídios Associados a Insulina e AloxanaNeoplasias/etiologiaNeoplasias/terapiaFosfolipídeos/uso terapêuticoInsulinaAloxanoSarcoma de YoshidaNeoplasms/etiologyNeoplasms/therapyPhospholipids/therapeutic useInsulinAlloxanSarcoma, YoshidaNeoplasias/etiologíaNeoplasias/terapiaFosfolípidos/uso terapêuticoInsulinaAloxanoSarcoma de YoshidaBasing themselves on certain existing relations between cancer and diabetes, the authors attempted to combine in an adequate manner the beneficent action of phospholipids with that of insulin. The experimental results were surprisingly favourable for it could be stated that the growth of the transplanted Yoshida sarcoma was inhibited completely in not less than 60 per cent of the treated animais, whereas in the remaining 40 per cent the growth was reduced to less than half. Alloxan, although in a lesser degree, showed similar favourable results when combined with phospholipids.Baseando-se em certas relações existentes entre a etiologia do câncer e a do diabetes, os autores procuram combinar de uma maneira adequada a ação benéfica dos fosfolipídeos com a da insulina. Os resultados experimentais foram surpreendentes, pois foi conseguida uma inibição total do crescimento do sarcoma de Yoshida em nada menos que 60% dos animais tratados, enquanto nos 40% restantes foi observado um retardamento do crescimento do tumor de 50% em relação ao controle. Aloxana, associada aos fosfolipídeos demonstrou, embora em menor escala, também um efeito favorável.INCA2023-08-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/401210.32635/2176-9745.RBC.1968v24n38.4012Revista Brasileira de Cancerologia; Vol. 24 No. 38 (1968): Oct.; 83-87Revista Brasileira de Cancerologia; Vol. 24 Núm. 38 (1968): oct.; 83-87Revista Brasileira de Cancerologia; v. 24 n. 38 (1968): out.; 83-872176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/4012/2806Copyright (c) 2023 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAltman, Reinout F. A.Spoladore, Luiz G.2023-08-18T19:50:50Zoai:rbc.inca.gov.br:article/4012Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-18T19:50:50Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
Efeitos Antimetastáticos e Citostáticos dos Fosfolipídios Associados a Insulina e Aloxana
title Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
spellingShingle Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
Altman, Reinout F. A.
Neoplasias/etiologia
Neoplasias/terapia
Fosfolipídeos/uso terapêutico
Insulina
Aloxano
Sarcoma de Yoshida
Neoplasms/etiology
Neoplasms/therapy
Phospholipids/therapeutic use
Insulin
Alloxan
Sarcoma, Yoshida
Neoplasias/etiología
Neoplasias/terapia
Fosfolípidos/uso terapêutico
Insulina
Aloxano
Sarcoma de Yoshida
title_short Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
title_full Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
title_fullStr Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
title_full_unstemmed Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
title_sort Antimetastatic and Cytostatic Effects of Phospholipids Combined With Insulin and Alloxan
author Altman, Reinout F. A.
author_facet Altman, Reinout F. A.
Spoladore, Luiz G.
author_role author
author2 Spoladore, Luiz G.
author2_role author
dc.contributor.author.fl_str_mv Altman, Reinout F. A.
Spoladore, Luiz G.
dc.subject.por.fl_str_mv Neoplasias/etiologia
Neoplasias/terapia
Fosfolipídeos/uso terapêutico
Insulina
Aloxano
Sarcoma de Yoshida
Neoplasms/etiology
Neoplasms/therapy
Phospholipids/therapeutic use
Insulin
Alloxan
Sarcoma, Yoshida
Neoplasias/etiología
Neoplasias/terapia
Fosfolípidos/uso terapêutico
Insulina
Aloxano
Sarcoma de Yoshida
topic Neoplasias/etiologia
Neoplasias/terapia
Fosfolipídeos/uso terapêutico
Insulina
Aloxano
Sarcoma de Yoshida
Neoplasms/etiology
Neoplasms/therapy
Phospholipids/therapeutic use
Insulin
Alloxan
Sarcoma, Yoshida
Neoplasias/etiología
Neoplasias/terapia
Fosfolípidos/uso terapêutico
Insulina
Aloxano
Sarcoma de Yoshida
description Basing themselves on certain existing relations between cancer and diabetes, the authors attempted to combine in an adequate manner the beneficent action of phospholipids with that of insulin. The experimental results were surprisingly favourable for it could be stated that the growth of the transplanted Yoshida sarcoma was inhibited completely in not less than 60 per cent of the treated animais, whereas in the remaining 40 per cent the growth was reduced to less than half. Alloxan, although in a lesser degree, showed similar favourable results when combined with phospholipids.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/4012
10.32635/2176-9745.RBC.1968v24n38.4012
url https://rbc.inca.gov.br/index.php/revista/article/view/4012
identifier_str_mv 10.32635/2176-9745.RBC.1968v24n38.4012
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/4012/2806
dc.rights.driver.fl_str_mv Copyright (c) 2023 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 24 No. 38 (1968): Oct.; 83-87
Revista Brasileira de Cancerologia; Vol. 24 Núm. 38 (1968): oct.; 83-87
Revista Brasileira de Cancerologia; v. 24 n. 38 (1968): out.; 83-87
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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