Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/4406 |
Resumo: | Introduction: There is no consensus in the literature on a reasonable delay time from diagnosis to radical prostatectomy (RP) surgery, without worsening the prognosis. Objective: To evaluate the influence of the delay on the risk of disease recurrence in patients with acinar adenocarcinoma of the prostate treated with RP. Method: Four hundred and twelve patients undergoing RP were retrospectively evaluated. Of these, 172 were excluded due to incomplete data and another 28 due to preoperative staging as high-risk prostate cancer (PSA > 10 ng/mL or Gleason score on biopsy > 7). Pre-and postoperative stagings were compared and survival analysis was performed using the Kaplan-Meier method to investigate the influence of time on discordance between pre- and postoperative stagings. Results: For the 212 patients of the sample, the average time from diagnosis to RP was 176.1 ± 120.2 days (median 145.5 days), ranging from 29 to a maximum of 798 days. The Kaplan-Meier curve indicated that the cancer worsened the longer the delay between diagnosis and surgery. Patients undergoing surgery within 60 days had an approximately 95% probability of not increasing the initial risk of recurrence. This number fell to 80%, 70% and 50% in patients operated on up to 100, 120 and 180 days, respectively. Conclusion: Delay in performing RP represents a continuous risk of relapse. The ideal time for RP is up to 60 days from prostate biopsy, as the probability of upstaging is less than 5% in this period. |
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Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence RiskRelación entre el Tiempo de Demora Hasta el Tratamiento Quirúrgico del Cáncer de Próstata y el Riesgo de Recurrencia de la EnfermedadRelação entre Tempo de Atraso no Tratamento Cirúrgico do Câncer de Próstata e Risco de Recorrência da DoençaNeoplasias da PróstataProstatectomiaTempo para o TratamentoProgressão da DoençaRecidiva Local de NeoplasiaProstatic NeoplasmsProstatectomyTime-to-TreatmentDisease ProgressionNeoplasm Recurrence, LocalNeoplasias de la PróstataProstatectomíaTiempo de TratamientoProgresión de la EnfermedadRecurrencia Local de NeoplasiaIntroduction: There is no consensus in the literature on a reasonable delay time from diagnosis to radical prostatectomy (RP) surgery, without worsening the prognosis. Objective: To evaluate the influence of the delay on the risk of disease recurrence in patients with acinar adenocarcinoma of the prostate treated with RP. Method: Four hundred and twelve patients undergoing RP were retrospectively evaluated. Of these, 172 were excluded due to incomplete data and another 28 due to preoperative staging as high-risk prostate cancer (PSA > 10 ng/mL or Gleason score on biopsy > 7). Pre-and postoperative stagings were compared and survival analysis was performed using the Kaplan-Meier method to investigate the influence of time on discordance between pre- and postoperative stagings. Results: For the 212 patients of the sample, the average time from diagnosis to RP was 176.1 ± 120.2 days (median 145.5 days), ranging from 29 to a maximum of 798 days. The Kaplan-Meier curve indicated that the cancer worsened the longer the delay between diagnosis and surgery. Patients undergoing surgery within 60 days had an approximately 95% probability of not increasing the initial risk of recurrence. This number fell to 80%, 70% and 50% in patients operated on up to 100, 120 and 180 days, respectively. Conclusion: Delay in performing RP represents a continuous risk of relapse. The ideal time for RP is up to 60 days from prostate biopsy, as the probability of upstaging is less than 5% in this period.Introducción: Según la literatura, no existe consenso sobre un tiempo razonable de retraso desde el diagnóstico hasta la cirugía de prostatectomía radical (PR), sin empeorar el pronóstico. Objetivo: Evaluar la influencia de este tiempo sobre el riesgo de recurrencia de la enfermedad en pacientes con adenocarcinoma acinar de próstata tratados con PR. Método: Se evaluaron retrospectivamente 412 pacientes sometidos a PR. De ellos, 172 fueron excluidos por datos incompletos y otros 28 por estadificación preoperatoria como cáncer de próstata de alto riesgo (PSA > 10 ng/mL o puntuación de Gleason en la biopsia > 7). Se compararon las estadificaciones pre y posoperatorias y se realizó un análisis de supervivencia utilizando el método de Kaplan-Meier para examinar la influencia del tiempo en la discordancia entre las estadificaciones pre y posoperatorias. Resultados: Para los 212 pacientes de la muestra, el tiempo promedio desde el diagnóstico hasta la PR fue de 176,1 ± 120,2 días (mediana 145,5 días), oscilando entre 29 y 798 días. La curva de Kaplan-Meier indicó que el cáncer empeoraba cuanto mayor era el retraso entre el diagnóstico y la cirugía. Los pacientes sometidos a cirugía dentro de los 60 días tenían aproximadamente un 95% de probabilidad de no aumentar el riesgo inicial de recurrencia. Esta cifra cayó al 80%, 70% y 50% en los pacientes operados hasta 100, 120 y 180 días, respectivamente. Conclusión: El retraso en la realización de la PR representa un riesgo continuo de restablecimiento de la neoplasia. El momento ideal para la PR es hasta los 60 días desde la biopsia de próstata, ya que la probabilidad de upstaging es inferior al 5% en este periodo.Introdução: De acordo com a literatura, não há consenso sobre um tempo de atraso razoável desde o diagnóstico até a operação da prostatectomia radical (PR) sem piora do prognóstico. Objetivo: Avaliar a influência desse tempo no risco de recorrência da doença em pacientes com adenocarcinoma acinar da próstata tratados com PR. Método: Quatrocentos e doze pacientes submetidos à PR foram avaliados retrospectivamente. Destes, 172 foram excluídos por dados incompletos e outros 28, por estadiamento pré- -operatório como câncer de próstata de alto risco (PSA > 10 ng/mL ou escore de Gleason na biópsia > 7). Os estadiamentos pré e pós-operatórios foram comparados, e a análise de sobrevida feita pelo método de Kaplan-Meier para examinar a influência do tempo na discordância entre os estadiamentos pré e pós-operatórios. Resultados: Para os 212 pacientes da amostra, o tempo médio desde o diagnóstico até a PR foi de 176,1 ± 120,2 dias (mediana de 145,5 dias), variando de 29 a um máximo de 798 dias. A curva de Kaplan-Meier indicou que o câncer piorava quanto maior o atraso entre o diagnóstico e a operação. Pacientes submetidos à cirurgia dentro de 60 dias tiveram cerca de 95% de probabilidade de não aumentarem o risco inicial de recorrência. Esse número caiu para 80%, 70% e 50% nos pacientes operados em até 100, 120 e 180 dias, respectivamente. Conclusão: O atraso na realização da PR representa risco contínuo de recorrência da neoplasia. O tempo ideal para PR é de até 60 dias a partir da biópsia da próstata, uma vez que a probabilidade de upstaging é inferior a 5% nesse período.INCA2024-02-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/440610.32635/2176-9745.RBC.2024v70n1.4406Revista Brasileira de Cancerologia; Vol. 70 No. 1 (2024): Jan./Feb./Mar.; e-024406Revista Brasileira de Cancerologia; Vol. 70 Núm. 1 (2024): ene./feb./mar.; e-024406Revista Brasileira de Cancerologia; v. 70 n. 1 (2024): jan./fev./mar.; e-0244062176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/4406/3351https://rbc.inca.gov.br/index.php/revista/article/view/4406/3359Copyright (c) 2024 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVeloso, Denny Fabrício MagalhãesVeloso, Denise SenaAndrade, André Felipe Zuccolo Barragat de2024-03-27T17:34:02Zoai:rbc.inca.gov.br:article/4406Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2024-03-27T17:34:02Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk Relación entre el Tiempo de Demora Hasta el Tratamiento Quirúrgico del Cáncer de Próstata y el Riesgo de Recurrencia de la Enfermedad Relação entre Tempo de Atraso no Tratamento Cirúrgico do Câncer de Próstata e Risco de Recorrência da Doença |
title |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk |
spellingShingle |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk Veloso, Denny Fabrício Magalhães Neoplasias da Próstata Prostatectomia Tempo para o Tratamento Progressão da Doença Recidiva Local de Neoplasia Prostatic Neoplasms Prostatectomy Time-to-Treatment Disease Progression Neoplasm Recurrence, Local Neoplasias de la Próstata Prostatectomía Tiempo de Tratamiento Progresión de la Enfermedad Recurrencia Local de Neoplasia |
title_short |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk |
title_full |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk |
title_fullStr |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk |
title_full_unstemmed |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk |
title_sort |
Relation between Delay Time to Surgical Treatment of Prostate Cancer and Disease Recurrence Risk |
author |
Veloso, Denny Fabrício Magalhães |
author_facet |
Veloso, Denny Fabrício Magalhães Veloso, Denise Sena Andrade, André Felipe Zuccolo Barragat de |
author_role |
author |
author2 |
Veloso, Denise Sena Andrade, André Felipe Zuccolo Barragat de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Veloso, Denny Fabrício Magalhães Veloso, Denise Sena Andrade, André Felipe Zuccolo Barragat de |
dc.subject.por.fl_str_mv |
Neoplasias da Próstata Prostatectomia Tempo para o Tratamento Progressão da Doença Recidiva Local de Neoplasia Prostatic Neoplasms Prostatectomy Time-to-Treatment Disease Progression Neoplasm Recurrence, Local Neoplasias de la Próstata Prostatectomía Tiempo de Tratamiento Progresión de la Enfermedad Recurrencia Local de Neoplasia |
topic |
Neoplasias da Próstata Prostatectomia Tempo para o Tratamento Progressão da Doença Recidiva Local de Neoplasia Prostatic Neoplasms Prostatectomy Time-to-Treatment Disease Progression Neoplasm Recurrence, Local Neoplasias de la Próstata Prostatectomía Tiempo de Tratamiento Progresión de la Enfermedad Recurrencia Local de Neoplasia |
description |
Introduction: There is no consensus in the literature on a reasonable delay time from diagnosis to radical prostatectomy (RP) surgery, without worsening the prognosis. Objective: To evaluate the influence of the delay on the risk of disease recurrence in patients with acinar adenocarcinoma of the prostate treated with RP. Method: Four hundred and twelve patients undergoing RP were retrospectively evaluated. Of these, 172 were excluded due to incomplete data and another 28 due to preoperative staging as high-risk prostate cancer (PSA > 10 ng/mL or Gleason score on biopsy > 7). Pre-and postoperative stagings were compared and survival analysis was performed using the Kaplan-Meier method to investigate the influence of time on discordance between pre- and postoperative stagings. Results: For the 212 patients of the sample, the average time from diagnosis to RP was 176.1 ± 120.2 days (median 145.5 days), ranging from 29 to a maximum of 798 days. The Kaplan-Meier curve indicated that the cancer worsened the longer the delay between diagnosis and surgery. Patients undergoing surgery within 60 days had an approximately 95% probability of not increasing the initial risk of recurrence. This number fell to 80%, 70% and 50% in patients operated on up to 100, 120 and 180 days, respectively. Conclusion: Delay in performing RP represents a continuous risk of relapse. The ideal time for RP is up to 60 days from prostate biopsy, as the probability of upstaging is less than 5% in this period. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/4406 10.32635/2176-9745.RBC.2024v70n1.4406 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/4406 |
identifier_str_mv |
10.32635/2176-9745.RBC.2024v70n1.4406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/4406/3351 https://rbc.inca.gov.br/index.php/revista/article/view/4406/3359 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2024 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2024 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 70 No. 1 (2024): Jan./Feb./Mar.; e-024406 Revista Brasileira de Cancerologia; Vol. 70 Núm. 1 (2024): ene./feb./mar.; e-024406 Revista Brasileira de Cancerologia; v. 70 n. 1 (2024): jan./fev./mar.; e-024406 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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1797042241960673280 |