Polymedication in Elderly Submitted to Oncological Treatment

Detalhes bibliográficos
Autor(a) principal: Laleska Pinheiro Alves, Brenda
Data de Publicação: 2020
Outros Autores: Graciele Nunes da Silva, Vanessa, Bacellar Martins Oliveira Silva Caetano, Idilva, Livinalli, Annemeri, Cruz, Maria Luiza
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/379
Resumo: Introduction: The elderly patient with cancer has potential risk of polymedication due to the increase of comorbidity and complexity of the cancer treatment, which often includes multiple antineoplastic and supportive medications. Objective: The objective is to identify the frequency of polypharmacy, potentially inappropriate medication use and drug interaction in elderly patients with cancer. Method: It were collected sociodemographic, pharmacological and clinical information from 20 elderly patients (≥ 65 years) with cancer, polymedicated (≥five drugs), from July to August 2016, in an outpatient clinic in Sao Luis, MA through electronic chart and questionnaires applied in interviews. To analyze the data, it were used the: Anatomical Therapeutic Chemical (ATC), Micromedex®, Drugs®, Lexicomp® and the Anfarmag Phytotherapy Guideline. Beers Criteria 2015 was used to identify potentially inappropriate medication for the elderly. Results: Among the patients, 70% were males, with a mean age of 73 years (SD=7.9). The most prevalent types of cancer were prostate cancer and breast. Cardiovascular and endocrine comorbidities were the most reported. A total of 134 drugs prescribed and self-medication were identified, of which 41 were antineoplastic. Eighty percent of the patients were exposed to potential risk of drug interaction, totaling 90 (63.2% of moderate, 21.2% of significant and 8.8% of mild severity). There were 4 interactions involving medicinal plants and seven inappropriate medications in use by 20% e 65% of the elderly patients, respectively. Conclusion: Among the patients included in this study, it was verified the occurrence of polypharmacy, potential drug interactions and the use of potentially inappropriate medications for the elderly.
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spelling Polymedication in Elderly Submitted to Oncological TreatmentPolimedicación en Personas Mayores Recibiendo el Tratamiento OncológicoPolimedicação em Idosos Submetidos a Tratamento OncológicoPolimedicaçãoNeoplasias/tratamento farmacológicoAntineoplásicosIdosoPolypharmacyNeoplasms/drug therapyAntineoplastic AgentsAgedPolifarmaciaNeoplasias/tratamiento farmacológicoAntineoplásicosAncianosIntroduction: The elderly patient with cancer has potential risk of polymedication due to the increase of comorbidity and complexity of the cancer treatment, which often includes multiple antineoplastic and supportive medications. Objective: The objective is to identify the frequency of polypharmacy, potentially inappropriate medication use and drug interaction in elderly patients with cancer. Method: It were collected sociodemographic, pharmacological and clinical information from 20 elderly patients (≥ 65 years) with cancer, polymedicated (≥five drugs), from July to August 2016, in an outpatient clinic in Sao Luis, MA through electronic chart and questionnaires applied in interviews. To analyze the data, it were used the: Anatomical Therapeutic Chemical (ATC), Micromedex®, Drugs®, Lexicomp® and the Anfarmag Phytotherapy Guideline. Beers Criteria 2015 was used to identify potentially inappropriate medication for the elderly. Results: Among the patients, 70% were males, with a mean age of 73 years (SD=7.9). The most prevalent types of cancer were prostate cancer and breast. Cardiovascular and endocrine comorbidities were the most reported. A total of 134 drugs prescribed and self-medication were identified, of which 41 were antineoplastic. Eighty percent of the patients were exposed to potential risk of drug interaction, totaling 90 (63.2% of moderate, 21.2% of significant and 8.8% of mild severity). There were 4 interactions involving medicinal plants and seven inappropriate medications in use by 20% e 65% of the elderly patients, respectively. Conclusion: Among the patients included in this study, it was verified the occurrence of polypharmacy, potential drug interactions and the use of potentially inappropriate medications for the elderly.Introducción: Un paciente con cáncer de edad avanzada tiene riesgo potencial de polmedicación debido a mayor comorbilidad y complejidad del tratamiento del cáncer, que incluye múltiples medicamentos antineoplásicos y de soporte. Objectivo: Identificar la frecuencia de polifarmacia, de uso de medicamentos potencialmente inapropiados y interacciones medicamentosa en personas mayores con cancro. Método: En el periodo de julio a agosto de 2016, en ambulatorio en Sao Luis – MA, se recolecto informaciones sociodemográficas, farmacológicas y clínicas de 20 pacientes ancianos (≥ 65 anos) cancro, polimedicados (≥ cinco medicamentos), por medio de recolección en registro medico electrónico y cuestionarios. Para análisis de datos, se utilizaron herramientas como Clasificación Anatómica Terapéutica Química, Micromedex®, Drugs®, Lexicomp® y Manual de fitoterápicos de la Anfarmag. Beers Criteria 2015 se utilizo para identificar los medicamentos potencialmente inapropiados para ancianos. Resultados: Entre los pacientes, 70% eran del sexo masculino, con edad promedio de 73 anos (DP=7,9). Los tipos de cancro mas prevalentes fueron de próstata y mama. En cuanto a las comorbilidades, las cardiovasculares y endocrinas fueron las mas relatadas. Se identificaron 134 prescripciones y automedicación, de los cuales 41 antineoplásicos. 80% de pacientes estaban expuestos a interacción medicamentosa, totalizando 90 (63,2% de gravedad moderada, 21,2% importantes y 8,8% leves). Se detectaron 4 interacciones que involucra plantas medicinales y siete medicamentos inapropriados para ancianos en el 20% y 65% de los pacientes, respectivamente. Conclusión: Entre los pacientes incluidos en estudio, verificamos aparición de polifarmacia, riesgos de posibles interacciones medicamentosas y el uso de medicamentos potencialmente inapropiados para los ancianos.Introdução: O paciente idoso com câncer possui risco potencial de polimedicação pelo aumento de comorbidade e complexidade do tratamento do câncer que, muitas vezes, inclui múltiplos antineoplásicos e medicamentos de suporte. Objetivo: Identificar a frequência de polimedicação, o uso de medicamentos potencialmente inapropriados e a interação medicamentosa em pacientes idosos com câncer. Método: Coletaram-se informações sociodemográficas, farmacológicas e clinicas de 20 pacientes idosos (≥65 anos) com câncer, polimedicados (≥cinco medicamentos), de julho a agosto de 2016, em um ambulatório em São Luís – MA, por meio de prontuário eletrônico e questionários aplicados em entrevistas. Para analise dos dados, utilizaram-se as ferramentas: Classificação Anatômica Terapêutica Química, Micromedex®, Drugs®, Lexicomp® e o Manual de fitoterápicos da Anfarmag. O Beers Criteria 2015 foi utilizado para identificação dos medicamentos potencialmente inapropriados para idosos. Resultados: Entre os pacientes, 70% eram do sexo masculino, com idade media de 73 anos (DP=7,9). Os tipos de câncer mais prevalentes foram os de próstata e mama. Quanto às comorbidades, as cardiovasculares e as endócrinas foram as mais relatadas. Foram identificados 134 medicamentos prescritos e de automedicação, dos quais, 41 eram antineoplásicos. Oitenta por cento dos pacientes estavam expostos a risco potencial de interação medicamentosa, totalizando 90 (63,2% de gravidade moderada, 21,2% importante e 8,8% menor). Detectaram-se quatro interações envolvendo plantas medicinais e sete medicamentos inapropriados para idosos em 20% e 65% dos pacientes, respectivamente. Conclusão: Entre os pacientes incluídos neste estudo, verificou-se a ocorrência de polimedicação, de interações medicamentosas potenciais e do uso de medicamentos potencialmente inapropriados para idosos.INCA2020-01-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/37910.32635/2176-9745.RBC.2019v65n4.379Revista Brasileira de Cancerologia; Vol. 65 No. 4 (2019): Oct./Nov./Dec.; e-09379Revista Brasileira de Cancerologia; Vol. 65 Núm. 4 (2019): oct./nov./dic.; e-09379Revista Brasileira de Cancerologia; v. 65 n. 4 (2019): out./nov./dez.; e-093792176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/379/531https://rbc.inca.gov.br/index.php/revista/article/view/379/650Copyright (c) 2020 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessLaleska Pinheiro Alves, BrendaGraciele Nunes da Silva, VanessaBacellar Martins Oliveira Silva Caetano, IdilvaLivinalli, AnnemeriCruz, Maria Luiza2021-11-29T20:03:14Zoai:rbc.inca.gov.br:article/379Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:03:14Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Polymedication in Elderly Submitted to Oncological Treatment
Polimedicación en Personas Mayores Recibiendo el Tratamiento Oncológico
Polimedicação em Idosos Submetidos a Tratamento Oncológico
title Polymedication in Elderly Submitted to Oncological Treatment
spellingShingle Polymedication in Elderly Submitted to Oncological Treatment
Laleska Pinheiro Alves, Brenda
Polimedicação
Neoplasias/tratamento farmacológico
Antineoplásicos
Idoso
Polypharmacy
Neoplasms/drug therapy
Antineoplastic Agents
Aged
Polifarmacia
Neoplasias/tratamiento farmacológico
Antineoplásicos
Ancianos
title_short Polymedication in Elderly Submitted to Oncological Treatment
title_full Polymedication in Elderly Submitted to Oncological Treatment
title_fullStr Polymedication in Elderly Submitted to Oncological Treatment
title_full_unstemmed Polymedication in Elderly Submitted to Oncological Treatment
title_sort Polymedication in Elderly Submitted to Oncological Treatment
author Laleska Pinheiro Alves, Brenda
author_facet Laleska Pinheiro Alves, Brenda
Graciele Nunes da Silva, Vanessa
Bacellar Martins Oliveira Silva Caetano, Idilva
Livinalli, Annemeri
Cruz, Maria Luiza
author_role author
author2 Graciele Nunes da Silva, Vanessa
Bacellar Martins Oliveira Silva Caetano, Idilva
Livinalli, Annemeri
Cruz, Maria Luiza
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Laleska Pinheiro Alves, Brenda
Graciele Nunes da Silva, Vanessa
Bacellar Martins Oliveira Silva Caetano, Idilva
Livinalli, Annemeri
Cruz, Maria Luiza
dc.subject.por.fl_str_mv Polimedicação
Neoplasias/tratamento farmacológico
Antineoplásicos
Idoso
Polypharmacy
Neoplasms/drug therapy
Antineoplastic Agents
Aged
Polifarmacia
Neoplasias/tratamiento farmacológico
Antineoplásicos
Ancianos
topic Polimedicação
Neoplasias/tratamento farmacológico
Antineoplásicos
Idoso
Polypharmacy
Neoplasms/drug therapy
Antineoplastic Agents
Aged
Polifarmacia
Neoplasias/tratamiento farmacológico
Antineoplásicos
Ancianos
description Introduction: The elderly patient with cancer has potential risk of polymedication due to the increase of comorbidity and complexity of the cancer treatment, which often includes multiple antineoplastic and supportive medications. Objective: The objective is to identify the frequency of polypharmacy, potentially inappropriate medication use and drug interaction in elderly patients with cancer. Method: It were collected sociodemographic, pharmacological and clinical information from 20 elderly patients (≥ 65 years) with cancer, polymedicated (≥five drugs), from July to August 2016, in an outpatient clinic in Sao Luis, MA through electronic chart and questionnaires applied in interviews. To analyze the data, it were used the: Anatomical Therapeutic Chemical (ATC), Micromedex®, Drugs®, Lexicomp® and the Anfarmag Phytotherapy Guideline. Beers Criteria 2015 was used to identify potentially inappropriate medication for the elderly. Results: Among the patients, 70% were males, with a mean age of 73 years (SD=7.9). The most prevalent types of cancer were prostate cancer and breast. Cardiovascular and endocrine comorbidities were the most reported. A total of 134 drugs prescribed and self-medication were identified, of which 41 were antineoplastic. Eighty percent of the patients were exposed to potential risk of drug interaction, totaling 90 (63.2% of moderate, 21.2% of significant and 8.8% of mild severity). There were 4 interactions involving medicinal plants and seven inappropriate medications in use by 20% e 65% of the elderly patients, respectively. Conclusion: Among the patients included in this study, it was verified the occurrence of polypharmacy, potential drug interactions and the use of potentially inappropriate medications for the elderly.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/379
10.32635/2176-9745.RBC.2019v65n4.379
url https://rbc.inca.gov.br/index.php/revista/article/view/379
identifier_str_mv 10.32635/2176-9745.RBC.2019v65n4.379
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/379/531
https://rbc.inca.gov.br/index.php/revista/article/view/379/650
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 65 No. 4 (2019): Oct./Nov./Dec.; e-09379
Revista Brasileira de Cancerologia; Vol. 65 Núm. 4 (2019): oct./nov./dic.; e-09379
Revista Brasileira de Cancerologia; v. 65 n. 4 (2019): out./nov./dez.; e-09379
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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