Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional do INMETRO |
Texto Completo: | http://hdl.handle.net/10926/1939 |
Resumo: | Objective: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. Material and Methods: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. Results: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p<0.05), which was in contrast to the similar volume density of the newly formed bone and biomaterials in relation to the control group. Conclusion: Thus, we concluded that HA-1 and HA-2 are biocompatible and non-degradable, and that crystallinity does not affect bone repair of critical size defects. |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHydroxyapatite crystallinity does not affect the repair of critical size bone defects20112013-01-16T15:04:13Z2013-01-16T15:04:13ZObjective: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. Material and Methods: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. Results: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p<0.05), which was in contrast to the similar volume density of the newly formed bone and biomaterials in relation to the control group. Conclusion: Thus, we concluded that HA-1 and HA-2 are biocompatible and non-degradable, and that crystallinity does not affect bone repair of critical size defects.6 p. : il., tab.Submitted by Lívia Oliveira (livia.oliveira2@hotmail.com) on 2012-07-19T13:47:01Z No. of bitstreams: 1 Granjeiro9_2011.pdf: 1213264 bytes, checksum: 40548f26d1fc4033cdfeac2d14f557dd (MD5)Approved for entry into archive by Regina Mello(mrmello@inmetro.gov.br) on 2013-01-16T15:04:13Z (GMT) No. of bitstreams: 1 Granjeiro9_2011.pdf: 1213264 bytes, checksum: 40548f26d1fc4033cdfeac2d14f557dd (MD5)Made available in DSpace on 2013-01-16T15:04:13Z (GMT). No. of bitstreams: 1 Granjeiro9_2011.pdf: 1213264 bytes, checksum: 40548f26d1fc4033cdfeac2d14f557dd (MD5) Previous issue date: 2011enghttp://hdl.handle.net/10926/1939DMD_hdl_10926/1939CONZ, Marcio Baltazar; GRANJEIRO, José Mauro; SOARES, Gloria de Almeida. Hydroxyapatite crystallinity does not affect the repair of critical size bone defects. Journal of Applied Oral Science, v. 19, n. 4, p. 337-342, 2011.Conz, Marcio BaltazarGranjeiro, José MauroSoares, Glória Dulce de Almeidainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do INMETROinstname:Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO)instacron:INMETROConz_2011.pdfhttp://xrepo01s.inmetro.gov.br/bitstream/10926/1939/1/Conz_2011.pdfapplication/pdf1213264http://xrepo01s.inmetro.gov.br/bitstream/10926/1939/1/Conz_2011.pdf40548f26d1fc4033cdfeac2d14f557ddMD510926_1939_12024-06-10T15:24:54Zoai:xrepo01s.inmetro.gov.br:10926/1939Repositório de Publicaçõeshttp://repositorios.inmetro.gov.br/oai/requestopendoar:2013-07-08T16:26:09Repositório Institucional do INMETRO - Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO)false |
dc.title.none.fl_str_mv |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
title |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
spellingShingle |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects Conz, Marcio Baltazar |
title_short |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
title_full |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
title_fullStr |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
title_full_unstemmed |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
title_sort |
Hydroxyapatite crystallinity does not affect the repair of critical size bone defects |
author |
Conz, Marcio Baltazar |
author_facet |
Conz, Marcio Baltazar Granjeiro, José Mauro Soares, Glória Dulce de Almeida |
author_role |
author |
author2 |
Granjeiro, José Mauro Soares, Glória Dulce de Almeida |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Conz, Marcio Baltazar Granjeiro, José Mauro Soares, Glória Dulce de Almeida |
description |
Objective: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. Material and Methods: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. Results: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p<0.05), which was in contrast to the similar volume density of the newly formed bone and biomaterials in relation to the control group. Conclusion: Thus, we concluded that HA-1 and HA-2 are biocompatible and non-degradable, and that crystallinity does not affect bone repair of critical size defects. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.available.fl_str_mv |
2013-01-16T15:04:13Z |
dc.date.accessioned.fl_str_mv |
2013-01-16T15:04:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10926/1939 DMD_hdl_10926/1939 |
dc.identifier.citation.fl_str_mv |
CONZ, Marcio Baltazar; GRANJEIRO, José Mauro; SOARES, Gloria de Almeida. Hydroxyapatite crystallinity does not affect the repair of critical size bone defects. Journal of Applied Oral Science, v. 19, n. 4, p. 337-342, 2011. |
url |
http://hdl.handle.net/10926/1939 |
identifier_str_mv |
DMD_hdl_10926/1939 CONZ, Marcio Baltazar; GRANJEIRO, José Mauro; SOARES, Gloria de Almeida. Hydroxyapatite crystallinity does not affect the repair of critical size bone defects. Journal of Applied Oral Science, v. 19, n. 4, p. 337-342, 2011. |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do INMETRO instname:Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO) instacron:INMETRO |
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Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO) |
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INMETRO |
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INMETRO |
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Repositório Institucional do INMETRO |
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Repositório Institucional do INMETRO |
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Repositório Institucional do INMETRO - Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO) |
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