Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of Byrsonima japurensis A. Juss. (Malpighiaceae)

• Autor(a) principal: Guilhon-Simplicio, Fernanda
• Data de Publicação: 2012
• Outros Autores: Pinheiro, Carlos Cleomir de Souza, Conrado, Gabrielly Galdino, Barbosa, Gleyce dos Santos, Santos, Pierre Alexandre dos, Pereira, Maria de Meneses, Lima, Emerson Silva
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional do INPA
• Texto Completo: https://repositorio.inpa.gov.br/handle/1/16139
• topic: Analgesic Agent; Antiinflammatory Agent; Antithrombocytic Agent; Antiulcer Agent; Beta Carotene; Byrsonima Japurensis Extract; Indometacin; Plant Extract; Superoxide; Unclassified Drug; Analgesic Activity; Animals Model; Anticoagulation; Antiinflammatory Activity; Antioxidant Activity; Antiulcer Activity; Bark; Bleaching; Blood Analysis; Clinical Evaluation; Concentration Response; Controlled Study; Dose Response; Drug Megadose; Drug Safety; Drug Screening; Female; Human; Human Tissue; Ic 50; In Vitro Study; Male; Malpighiaceae; Mouse; Nonhuman; Plant Stem; Rat; Medicine, Traditional; Analgesics; Animal; Anti-inflammatory Agents; Anti-inflammatory Agents, Non-steroidal; Anti-ulcer Agents; Antioxidants; Beta Carotene; Brasil; Carrageenan; Edema; Female; Humans; Male; Malpighiaceae; Mice; Mice, Inbred Balb C; Pain; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stomach Ulcer; Superoxides; Byrsonima; Malpighiaceae; Mus; Rattus; Rattus Norvegicus

Ethnopharmacological relevance: Decoctions or infusions of the stem bark of Byrsonima japurensis A. Juss. (Malpighiaceae) are widely used as an anti-inflammatory drug in folk medicine of Amazonas State (Brazil). Aim of the study: To evaluate the pharmacological potential of an aqueous extract of the stem bark of Byrsonima japurensis (BJEA) to scientifically verify of its traditional use. Materials and methods: Anti-inflammatory, antihyperalgesic and antiulcer activities were evaluated in Wistar rats, a Hippocratic screening was performed in Swiss mice to evaluate the toxic effects, and antiplatelet evaluation was performed in human platelet rich plasma assay. Additionally, antioxidant activity was evaluated by superoxide radical scavenging method and β-carotene bleaching test. Results: Anti-inflammatory, antihyperalgesic and gastroprotective activities were observed in rats treated orally with different doses of BJEA. While signals of toxicity were observed in the mice treated with a very high dose of extract (5000 mg/kg), no death occurred. BJEA also showed expressive antiplatelet and antioxidant activities in vitro. Conclusion: According to our results, it was concluded that stem bark of Byrsonima japurensis has significant and safe anti-inflammatory activity, which is closely related with their potent antioxidant activity, supporting the folk medicinal use of this species. Crown Copyright © 2012 Published by Elsevier Ireland Ltd. All rights reserved.