Antiulcer effect of Bidens pilosa L. and toxicological safety in rodents: comparative study between stem and root extracts

• Autor(a) principal: Alves Nascimento, Abel José
• Data de Publicação: 2018
• Outros Autores: Lucena de Lima, Bruno, Novaes da Silva, Artur Danilo, Carvalho Souza Lima Silva, Helder, Prado Lyra, Ricardo, Saraiva Dantas, Gabriela, de Alencar Menezes, Daniela, Lima Silva, Fabiana, Almeida Pereira, Schirley Cristina, Veiga da Silva, Joelmir Lucena
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Anais da Faculdade de Medicina de Olinda (Online)
• Texto Completo: https://afmo.emnuvens.com.br/afmo/article/view/26
• topic: Planta medicinal; Extrato vegetal; Agente antiúlcera; Toxicidade; Medicinal plant; Plant extract; Anti-ulcer; Toxicity

Purpose: To investigate and to compare the extracts of the stalks (Bpc-EtOH) and roots (Bpr-EtOH) from Bidens pilosa on ethanol-gastric ulcer model rats and acude toxicologial screening in mice. Methods: in the ulcer model were accessed the extracts on etanol-induced rat gastric lesions (n = 4-5). To analyze the safety toxicological those extracts in vivo, the acute toxicity screening was perfomed with sigle dose extracts and during three days in mice (n=5). Results: the Bpc-EtOH (150 and 500 mg/kg) protected the rat gastric mucosa layer (ULA=138.0 ± 30.5 and 96.3 ± 11.8 mm2, respectivelly). The Bpr-EtOH induced similar effects on all doses (ULA=178.3 ± 10.0; 67.4 ± 9.5 and 35.5 ± 14.3 mm2) and the most efficacy (Emax) than Bpc-EtOH. The omeprazole (ULA=145.7 ± 19.9 mm2) showed also protective effects as expected. The histophatology analyzes corroborated those results. The maximum dose 500 mg/kg (o.r.) of theextracts is safe and do not cause damages to animails because dose 2 g/kg (o.r.) in toxicological screening did fail.Conclusion: The stalks and roots from B. pilosa also present actives metabolites for antiulcer activity, it may be moreconcentration in roots or are different than stalks, and both are safe in doses tested.