Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC)
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1129 |
Resumo: | Currently the Chronic Obstructive Pulmonary Disease (COPD) has a high prevalence and a high economic and social cost. In this context, several experimental models have been proposed, aiming at the discovery of new therapeutic approaches. Accordingly, the use of mesenchymal stem cells (MSC) is an innovative and accessible treatment of pulmonary acute and chronic disease, as they have important therapeutic potentials (immunoregulation, anti-fibrogenic, inducing proliferation of tissue progenitor cells, anti-apoptotic and pro-angiogenic and chemoattraction). Therapy with low levellaser (LLL) is a relatively new effective therapy, with very low cost and no side effects. In this project we aim to study some parameters in animals with COPD undergoing therapies with LLL (15 days before the experiment) and MSC obtained from human fallopian tube (administered 2 times: 15 days and 7 days before the experiment). The protocol used for the induction of COPD consists in submitting C57BL/6 mice for 75 days (2 times / day) to inhaled cigarette smoke. On day 76ththe animals were sacrified and structural and functional parameters of lungs were evaluated. Our results indicate that the treatment with LLL and MSC greatly reduces lung inflammation (as demonstrated through BAL cell counting and histomorphometric analysis in lung parenchyma), BAL pro-inflammatory cytokines (IL-1??, IL-6, IL-10, TNF-?? and KC) and the lung expression of NF-???B, NFAT and IL-10. Furthermore, these therapies also reduced airway mucus secretion and collagen deposition. |
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Oliveira, Ana Paula Ligeiro dehttp://lattes.cnpq.br/5700855351581023Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/9213556008468472Carvalho, Fl??vio Aimbire Soares dehttp://lattes.cnpq.br/8216583445045638Vieira, Rodolfo de Paulahttp://lattes.cnpq.br/921355600846847224896238850Silva, Vanessa Roza da2015-07-20T17:06:31Z2013-12-19Silva, Vanessa Roza da. Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC). 2013. 120 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo .http://bibliotecatede.uninove.br/handle/tede/1129Currently the Chronic Obstructive Pulmonary Disease (COPD) has a high prevalence and a high economic and social cost. In this context, several experimental models have been proposed, aiming at the discovery of new therapeutic approaches. Accordingly, the use of mesenchymal stem cells (MSC) is an innovative and accessible treatment of pulmonary acute and chronic disease, as they have important therapeutic potentials (immunoregulation, anti-fibrogenic, inducing proliferation of tissue progenitor cells, anti-apoptotic and pro-angiogenic and chemoattraction). Therapy with low levellaser (LLL) is a relatively new effective therapy, with very low cost and no side effects. In this project we aim to study some parameters in animals with COPD undergoing therapies with LLL (15 days before the experiment) and MSC obtained from human fallopian tube (administered 2 times: 15 days and 7 days before the experiment). The protocol used for the induction of COPD consists in submitting C57BL/6 mice for 75 days (2 times / day) to inhaled cigarette smoke. On day 76ththe animals were sacrified and structural and functional parameters of lungs were evaluated. Our results indicate that the treatment with LLL and MSC greatly reduces lung inflammation (as demonstrated through BAL cell counting and histomorphometric analysis in lung parenchyma), BAL pro-inflammatory cytokines (IL-1??, IL-6, IL-10, TNF-?? and KC) and the lung expression of NF-???B, NFAT and IL-10. Furthermore, these therapies also reduced airway mucus secretion and collagen deposition.Atualmente a Doen??a Pulmonar Obstrutiva Cr??nica (DPOC) apresenta alta preval??ncia e um elevado custo econ??mico e social. Neste contexto, v??rios modelos experimentais t??m sido propostos, objetivando o descobrimento de novas op????es terap??uticas. Neste sentido, o uso de c??lulas-tronco mesenquimais (CTM) constitui uma estrat??gia inovadora e acess??vel para tratamento de doen??as pulmonares de car??ter agudo e cr??nico. Essas c??lulas-troncos possuem um importante potencial terap??utico (imunorregula????o, anti-fibrog??nica, indutora da prolifera????o de c??lulas progenitoras teciduais, anti-apopt??tica, pr??-angiog??nica e de quimioatra????o). A terapia com Laser de Baixa Pot??ncia (LBP) ?? uma terapia relativamente nova e eficaz, de baix??ssimo custo, sem efeitos colaterais e de poss??vel utiliza????o no tratamento das doen??as cr??nicas pulmonares. No presente estudo visamos estudar alguns par??metros em animais com DPOC submetidos ??s terapias com laser de diodo (660nm), 30 mW, 60 s por ponto (3 pontos por aplica????o) por 15 dias antes do experimento e com CTMs obtidas da tuba uterina humana (104 c??lulas administradas i.p. ou i.n. 2 vezes: 15 dias e 7 dias antes do experimento).O protocolo utilizado para a indu????o da DPOC consistiu em nebulizar camundongos f??meas C57BL/6 com fuma??a de cigarro por 75 dias (2 vezes/dia). No dia 76, os animais foram sacrificados e avaliados os par??metros funcionais e estruturais pulmonares.Nossos resultados indicam que os tratamentos com CTM e LBP reduziram a inflama????o pulmonar (demonstrado pela contagem total e diferencial de c??lulas do lavadobroncoalveolar (LBA) e an??lise histomorfom??trica do par??nquima pulmonar), os n??veis de citocinas quimiocinas (IL-1??, IL-6, IL-10, IFN-???, TNF-?? e, KC) e a express??o de NF-???B, NFAT e IL-10 no pulm??o. Al??m disso, essas terapias tamb??m reduziram a secre????o de muco e deposi????o de col??geno nas vias a??reas.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2015-07-20T17:06:31Z No. of bitstreams: 1 Vanessa Roza da Silva.pdf: 5985934 bytes, checksum: dd323ab2c936afdeb390f59867f9eab4 (MD5)Made available in DSpace on 2015-07-20T17:06:31Z (GMT). No. of bitstreams: 1 Vanessa Roza da Silva.pdf: 5985934 bytes, checksum: dd323ab2c936afdeb390f59867f9eab4 (MD5) Previous issue date: 2013-12-19application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??deUNINOVEBrasilSa??deDPOClaser de baixa pot??nciac??lulas-tronco mesenquimaisinflama????o pulmonarcitocinasCOPDlow level lasermesenchymal stem cellslung inflammationcytokinesCIENCIAS DA SAUDEEfeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALVanessa Roza da Silva.pdfVanessa Roza da Silva.pdfapplication/pdf5985934http://localhost:8080/tede/bitstream/tede/1129/2/Vanessa+Roza+da+Silva.pdfdd323ab2c936afdeb390f59867f9eab4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/tede/1129/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/11292015-07-20 14:06:31.727oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2015-07-20T17:06:31Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
title |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
spellingShingle |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) Silva, Vanessa Roza da DPOC laser de baixa pot??ncia c??lulas-tronco mesenquimais inflama????o pulmonar citocinas COPD low level laser mesenchymal stem cells lung inflammation cytokines CIENCIAS DA SAUDE |
title_short |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
title_full |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
title_fullStr |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
title_full_unstemmed |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
title_sort |
Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC) |
author |
Silva, Vanessa Roza da |
author_facet |
Silva, Vanessa Roza da |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Oliveira, Ana Paula Ligeiro de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5700855351581023 |
dc.contributor.advisor-co1.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/9213556008468472 |
dc.contributor.referee1.fl_str_mv |
Carvalho, Fl??vio Aimbire Soares de |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/8216583445045638 |
dc.contributor.referee2.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/9213556008468472 |
dc.contributor.authorID.fl_str_mv |
24896238850 |
dc.contributor.author.fl_str_mv |
Silva, Vanessa Roza da |
contributor_str_mv |
Oliveira, Ana Paula Ligeiro de Vieira, Rodolfo de Paula Carvalho, Fl??vio Aimbire Soares de Vieira, Rodolfo de Paula |
dc.subject.por.fl_str_mv |
DPOC laser de baixa pot??ncia c??lulas-tronco mesenquimais inflama????o pulmonar citocinas |
topic |
DPOC laser de baixa pot??ncia c??lulas-tronco mesenquimais inflama????o pulmonar citocinas COPD low level laser mesenchymal stem cells lung inflammation cytokines CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
COPD low level laser mesenchymal stem cells lung inflammation cytokines |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Currently the Chronic Obstructive Pulmonary Disease (COPD) has a high prevalence and a high economic and social cost. In this context, several experimental models have been proposed, aiming at the discovery of new therapeutic approaches. Accordingly, the use of mesenchymal stem cells (MSC) is an innovative and accessible treatment of pulmonary acute and chronic disease, as they have important therapeutic potentials (immunoregulation, anti-fibrogenic, inducing proliferation of tissue progenitor cells, anti-apoptotic and pro-angiogenic and chemoattraction). Therapy with low levellaser (LLL) is a relatively new effective therapy, with very low cost and no side effects. In this project we aim to study some parameters in animals with COPD undergoing therapies with LLL (15 days before the experiment) and MSC obtained from human fallopian tube (administered 2 times: 15 days and 7 days before the experiment). The protocol used for the induction of COPD consists in submitting C57BL/6 mice for 75 days (2 times / day) to inhaled cigarette smoke. On day 76ththe animals were sacrified and structural and functional parameters of lungs were evaluated. Our results indicate that the treatment with LLL and MSC greatly reduces lung inflammation (as demonstrated through BAL cell counting and histomorphometric analysis in lung parenchyma), BAL pro-inflammatory cytokines (IL-1??, IL-6, IL-10, TNF-?? and KC) and the lung expression of NF-???B, NFAT and IL-10. Furthermore, these therapies also reduced airway mucus secretion and collagen deposition. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-12-19 |
dc.date.accessioned.fl_str_mv |
2015-07-20T17:06:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Silva, Vanessa Roza da. Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC). 2013. 120 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo . |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1129 |
identifier_str_mv |
Silva, Vanessa Roza da. Efeito da associa????o das terapias com lazer de baixa pot??ncia (LBP) e c??lulas- tronco mesenquimais derivadas de tuba uterina humana sobre a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC). 2013. 120 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo . |
url |
http://bibliotecatede.uninove.br/handle/tede/1129 |
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por |
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por |
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