Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Psychology & Neuroscience (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882014000200008 |
Resumo: | The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood. |
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Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthoodhypoxianeurodevelopmenthyperactivitycell survivalschizophreniaThe present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882014000200008Psychology & Neuroscience v.7 n.2 2014reponame:Psychology & Neuroscience (Online)instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)instacron:PUCRJ10.3922/j.psns.2014.02.03info:eu-repo/semantics/openAccessYamada,Karen Y.Satake,Susan Y.Perry,Juliana C.Garcia,Karina O.D'Almeida,VâniaTufik,SergioLongo,Beatriz M.Barbosa-Silva,Regina C.eng2014-07-31T00:00:00Zoai:scielo:S1983-32882014000200008Revistahttps://www.apa.org/pubs/journals/pnePRIhttps://old.scielo.br/oai/scielo-oai.phppsycneuro@psycneuro.org1983-32881984-3054opendoar:2014-07-31T00:00Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)false |
dc.title.none.fl_str_mv |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
spellingShingle |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood Yamada,Karen Y. hypoxia neurodevelopment hyperactivity cell survival schizophrenia |
title_short |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_full |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_fullStr |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_full_unstemmed |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_sort |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
author |
Yamada,Karen Y. |
author_facet |
Yamada,Karen Y. Satake,Susan Y. Perry,Juliana C. Garcia,Karina O. D'Almeida,Vânia Tufik,Sergio Longo,Beatriz M. Barbosa-Silva,Regina C. |
author_role |
author |
author2 |
Satake,Susan Y. Perry,Juliana C. Garcia,Karina O. D'Almeida,Vânia Tufik,Sergio Longo,Beatriz M. Barbosa-Silva,Regina C. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Yamada,Karen Y. Satake,Susan Y. Perry,Juliana C. Garcia,Karina O. D'Almeida,Vânia Tufik,Sergio Longo,Beatriz M. Barbosa-Silva,Regina C. |
dc.subject.por.fl_str_mv |
hypoxia neurodevelopment hyperactivity cell survival schizophrenia |
topic |
hypoxia neurodevelopment hyperactivity cell survival schizophrenia |
description |
The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882014000200008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882014000200008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3922/j.psns.2014.02.03 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
dc.source.none.fl_str_mv |
Psychology & Neuroscience v.7 n.2 2014 reponame:Psychology & Neuroscience (Online) instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) instacron:PUCRJ |
instname_str |
Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
instacron_str |
PUCRJ |
institution |
PUCRJ |
reponame_str |
Psychology & Neuroscience (Online) |
collection |
Psychology & Neuroscience (Online) |
repository.name.fl_str_mv |
Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
repository.mail.fl_str_mv |
psycneuro@psycneuro.org |
_version_ |
1754821073179770880 |