Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood

Detalhes bibliográficos
Autor(a) principal: Yamada, Karen Yukie [UNIFESP]
Data de Publicação: 2014
Outros Autores: Satake, Susan [UNIFESP], Perry, Juliana Cini [UNIFESP], Garcia, Karina de Oliveira [UNIFESP], D'Almeida, Vânia [UNIFESP], Tufik, Sergio [UNIFESP], Longo, Beatriz Monteiro [UNIFESP], Silva, Regina Cláudia Barbosa da [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/8453
https://dx.doi.org/10.3922/j.psns.2014.02.03
Resumo: The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.
id UFSP_243c35b6279b7abbf5f0b514a97fe93c
oai_identifier_str oai:repositorio.unifesp.br:11600/8453
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Yamada, Karen Yukie [UNIFESP]Satake, Susan [UNIFESP]Perry, Juliana Cini [UNIFESP]Garcia, Karina de Oliveira [UNIFESP]D'Almeida, Vânia [UNIFESP]Tufik, Sergio [UNIFESP]Longo, Beatriz Monteiro [UNIFESP]Silva, Regina Cláudia Barbosa da [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:47:10Z2015-06-14T13:47:10Z2014-06-01Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.1983-3288https://repositorio.unifesp.br/handle/11600/8453https://dx.doi.org/10.3922/j.psns.2014.02.03S1983-32882014000200008.pdfS1983-3288201400020000810.3922/j.psns.2014.02.03The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP)UNIFESPFAPESP: 2006/61223-3FAPESP: 2009/07278-9FAPESP: 2009/07347-0FAPESP: 2009/03616-7FAPESP: 2010/00120-8CEPID: 98/14303-3SciELO125-130engPontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São PauloPsychology & NeuroscienceHypoxiaNeurodevelopmentHyperactivityCell survivalSchizophreniaEffect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthoodinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1983-32882014000200008.pdfapplication/pdf1420081${dspace.ui.url}/bitstream/11600/8453/1/S1983-32882014000200008.pdfa238af4fd734d6bcf1a0fb96acf22c5dMD51open accessTEXTS1983-32882014000200008.pdf.txtS1983-32882014000200008.pdf.txtExtracted texttext/plain28097${dspace.ui.url}/bitstream/11600/8453/6/S1983-32882014000200008.pdf.txt9a3142f2c68c8d5e6af2b68a9551bfb4MD56open accessTHUMBNAILS1983-32882014000200008.pdf.jpgS1983-32882014000200008.pdf.jpgIM Thumbnailimage/jpeg7154${dspace.ui.url}/bitstream/11600/8453/8/S1983-32882014000200008.pdf.jpgfde455cdf5d8e2ddf6bc37d16fc761b2MD58open access11600/84532023-06-05 19:14:10.284open accessoai:repositorio.unifesp.br:11600/8453Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:14:10Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
title Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
spellingShingle Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
Yamada, Karen Yukie [UNIFESP]
Hypoxia
Neurodevelopment
Hyperactivity
Cell survival
Schizophrenia
title_short Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
title_full Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
title_fullStr Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
title_full_unstemmed Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
title_sort Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
author Yamada, Karen Yukie [UNIFESP]
author_facet Yamada, Karen Yukie [UNIFESP]
Satake, Susan [UNIFESP]
Perry, Juliana Cini [UNIFESP]
Garcia, Karina de Oliveira [UNIFESP]
D'Almeida, Vânia [UNIFESP]
Tufik, Sergio [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
Silva, Regina Cláudia Barbosa da [UNIFESP]
author_role author
author2 Satake, Susan [UNIFESP]
Perry, Juliana Cini [UNIFESP]
Garcia, Karina de Oliveira [UNIFESP]
D'Almeida, Vânia [UNIFESP]
Tufik, Sergio [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
Silva, Regina Cláudia Barbosa da [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Yamada, Karen Yukie [UNIFESP]
Satake, Susan [UNIFESP]
Perry, Juliana Cini [UNIFESP]
Garcia, Karina de Oliveira [UNIFESP]
D'Almeida, Vânia [UNIFESP]
Tufik, Sergio [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
Silva, Regina Cláudia Barbosa da [UNIFESP]
dc.subject.eng.fl_str_mv Hypoxia
Neurodevelopment
Hyperactivity
Cell survival
Schizophrenia
topic Hypoxia
Neurodevelopment
Hyperactivity
Cell survival
Schizophrenia
description The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.
publishDate 2014
dc.date.issued.fl_str_mv 2014-06-01
dc.date.accessioned.fl_str_mv 2015-06-14T13:47:10Z
dc.date.available.fl_str_mv 2015-06-14T13:47:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/8453
https://dx.doi.org/10.3922/j.psns.2014.02.03
dc.identifier.issn.none.fl_str_mv 1983-3288
dc.identifier.file.none.fl_str_mv S1983-32882014000200008.pdf
dc.identifier.scielo.none.fl_str_mv S1983-32882014000200008
dc.identifier.doi.none.fl_str_mv 10.3922/j.psns.2014.02.03
identifier_str_mv Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.
1983-3288
S1983-32882014000200008.pdf
S1983-32882014000200008
10.3922/j.psns.2014.02.03
url https://repositorio.unifesp.br/handle/11600/8453
https://dx.doi.org/10.3922/j.psns.2014.02.03
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Psychology & Neuroscience
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 125-130
dc.publisher.none.fl_str_mv Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo
publisher.none.fl_str_mv Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
bitstream.url.fl_str_mv ${dspace.ui.url}/bitstream/11600/8453/1/S1983-32882014000200008.pdf
${dspace.ui.url}/bitstream/11600/8453/6/S1983-32882014000200008.pdf.txt
${dspace.ui.url}/bitstream/11600/8453/8/S1983-32882014000200008.pdf.jpg
bitstream.checksum.fl_str_mv a238af4fd734d6bcf1a0fb96acf22c5d
9a3142f2c68c8d5e6af2b68a9551bfb4
fde455cdf5d8e2ddf6bc37d16fc761b2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1783460247820566528

Registros relacionados