Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models

• Autor(a) principal: Reckziegel,Ramiro
• Data de Publicação: 2022
• Outros Autores: Czepielewski,Letícia S., Hasse-Sousa,Mathias, Martins,Dayane S., de Britto,Maria J., Lapa,Clara de O., Schwartzhaupt,Alexandre W., Gama,Clarissa S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000100074
• topic: Schizophrenia; cognition; aging; neurodevelopment; neuroprogression

The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.