Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9288 |
Resumo: | ObjectiveThe ketogenic diet is used as a therapeutic alternative for the treatment of epilepsy in patients with refractory epilepsy. It simulates biochemical changes typical of fasting. The present study verified the nutritional impact of the ketogenic diet on children with refractory epilepsy. MethodsNutritional status data (dietary, biochemical and anthropometric measurements), seizure frequency, and adverse events were collected from the medical records and during outpatient clinic visits of children over a period of 36 months. ResultsOf the 29 children who initiated the ketogenic diet, 75.8% presented fewer seizures after one month of treatment. After six months, 48.3% of the patients had at least a 90.0% decrease in seizure frequency, and 50.0% of these patients presented total seizure remission. At 12 months, eight patients continued to show positive results, and seven of these children remained on the ketogenic diet for 24 months. There was an improvement of the nutritional status at 24 months, especially in terms of weight, which culminated with the recovery of proper weight-for-height. There were no significant changes in biochemical indices (total cholesterol and components, triglycerides, albumin, total protein, creatinine, glycemia, serum aspartate transaminase andserum alanine transaminase). Serum cholesterol levels increased significantly in the first month, fell in the following six months, and remained within the normal limits thereafter. ConclusionIn conclusion, patients on the classic ketogenic diet for at least 24 months gained weight. Moreover, approximately one third of the patients achieved significant reduction in seizure frequency, and some patients achieved total remission. |
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Effect of the classic ketogenic diet on the treatment of refractory epileptic seizuresEfeito da dieta cetogênica clássica no tratamento de crises epilépticas refratáriasEpilepsyKetogenic dietNutritional statusEpilepsiaDieta cetogênicaEstado nutricionalObjectiveThe ketogenic diet is used as a therapeutic alternative for the treatment of epilepsy in patients with refractory epilepsy. It simulates biochemical changes typical of fasting. The present study verified the nutritional impact of the ketogenic diet on children with refractory epilepsy. MethodsNutritional status data (dietary, biochemical and anthropometric measurements), seizure frequency, and adverse events were collected from the medical records and during outpatient clinic visits of children over a period of 36 months. ResultsOf the 29 children who initiated the ketogenic diet, 75.8% presented fewer seizures after one month of treatment. After six months, 48.3% of the patients had at least a 90.0% decrease in seizure frequency, and 50.0% of these patients presented total seizure remission. At 12 months, eight patients continued to show positive results, and seven of these children remained on the ketogenic diet for 24 months. There was an improvement of the nutritional status at 24 months, especially in terms of weight, which culminated with the recovery of proper weight-for-height. There were no significant changes in biochemical indices (total cholesterol and components, triglycerides, albumin, total protein, creatinine, glycemia, serum aspartate transaminase andserum alanine transaminase). Serum cholesterol levels increased significantly in the first month, fell in the following six months, and remained within the normal limits thereafter. ConclusionIn conclusion, patients on the classic ketogenic diet for at least 24 months gained weight. Moreover, approximately one third of the patients achieved significant reduction in seizure frequency, and some patients achieved total remission. ObjetivoA dieta cetogênica é empregada como uma terapia alternativa para o tratamento da epilepsia em pacientes com epilepsia refratária e simula as alterações bioquímicas de jejum. Neste trabalho, verificou-se o impacto nutricional da dieta cetogênica em crianças com epilepsia refratária. MétodosOs dados sobre o estado nutricional (bioquímica, alimentar e medidas antropométricas), a frequência de crises e os eventos adversos de crianças acompanhadas durante 36 meses foram coletados de prontuários médicos e visitas ambulatoriais. ResultadosVinte e nove crianças iniciaram o tratamento; após um mês, 75,8% apresentaram redução das crises. Em seis meses, 48,3% dos pacientes tiveram pelo menos 90,0% de redução na frequência de crises, e, desses, 50,0% obtiveram o controle completo das crises. Aos doze meses, oito pacientes continuaram a apresentar resultados positivos, e, desses, sete permaneceram em dieta cetogênica durante 24 meses. Observou-se melhora do estado nutricional aos 24 meses de tratamento, especialmente em termos de peso, o que indica a recuperação da condição peso para altura. Não houve mudanças significativas nos índices bioquímicos analisados (colesterol total e de componentes, triglicerídeos, albumina, proteína total, creatinina, glicemia, transaminase glutâmico oxala-cética sérica e transaminase glutâmico pirúvico sérica). Os níveis de colesterol aumentaram significativamente no primeiro mês, mas diminuíram nos seis meses seguintes e, posteriormente, se mantiveram dentro dos valo-res de referência. ConclusãoOs pacientes em uso da dieta cetogênica clássica por pelo menos 24 meses apresentaram melhora de peso e cerca de um terço dos pacientes conseguiu uma redução significativa da frequência de crises, com alguns pacientes completamente livres delas.Núcleo de Editoração – PUC-Campinas2023-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9288Brazilian Journal of Nutrition; Vol. 25 No. 5 (2012): Revista de NutriçãoRevista de Nutrição; Vol. 25 Núm. 5 (2012): Revista de NutriçãoRevista de Nutrição; v. 25 n. 5 (2012): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPenghttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9288/6667Copyright (c) 2023 Luciana Duarte MARTINS, Vera Cristina TERRA, Carolina Ferreira NICOLETTI, Paula Garcia CHIARELLO, Julio Sérgio MARCHINI, Américo Ceiki SAKAMOTO, Carla Barbosa NONINO-BORGEShttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDuarte MARTINS, Luciana TERRA, Vera CristinaFerreira NICOLETTI, Carolina Garcia CHIARELLO, Paula MARCHINI, Julio Sérgio Ceiki SAKAMOTO, AméricoBarbosa NONINO-BORGES, Carla 2023-10-05T19:07:59Zoai:ojs.periodicos.puc-campinas.edu.br:article/9288Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-10-05T19:07:59Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures Efeito da dieta cetogênica clássica no tratamento de crises epilépticas refratárias |
title |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures |
spellingShingle |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures Duarte MARTINS, Luciana Epilepsy Ketogenic diet Nutritional status Epilepsia Dieta cetogênica Estado nutricional |
title_short |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures |
title_full |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures |
title_fullStr |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures |
title_full_unstemmed |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures |
title_sort |
Effect of the classic ketogenic diet on the treatment of refractory epileptic seizures |
author |
Duarte MARTINS, Luciana |
author_facet |
Duarte MARTINS, Luciana TERRA, Vera Cristina Ferreira NICOLETTI, Carolina Garcia CHIARELLO, Paula MARCHINI, Julio Sérgio Ceiki SAKAMOTO, Américo Barbosa NONINO-BORGES, Carla |
author_role |
author |
author2 |
TERRA, Vera Cristina Ferreira NICOLETTI, Carolina Garcia CHIARELLO, Paula MARCHINI, Julio Sérgio Ceiki SAKAMOTO, Américo Barbosa NONINO-BORGES, Carla |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Duarte MARTINS, Luciana TERRA, Vera Cristina Ferreira NICOLETTI, Carolina Garcia CHIARELLO, Paula MARCHINI, Julio Sérgio Ceiki SAKAMOTO, Américo Barbosa NONINO-BORGES, Carla |
dc.subject.por.fl_str_mv |
Epilepsy Ketogenic diet Nutritional status Epilepsia Dieta cetogênica Estado nutricional |
topic |
Epilepsy Ketogenic diet Nutritional status Epilepsia Dieta cetogênica Estado nutricional |
description |
ObjectiveThe ketogenic diet is used as a therapeutic alternative for the treatment of epilepsy in patients with refractory epilepsy. It simulates biochemical changes typical of fasting. The present study verified the nutritional impact of the ketogenic diet on children with refractory epilepsy. MethodsNutritional status data (dietary, biochemical and anthropometric measurements), seizure frequency, and adverse events were collected from the medical records and during outpatient clinic visits of children over a period of 36 months. ResultsOf the 29 children who initiated the ketogenic diet, 75.8% presented fewer seizures after one month of treatment. After six months, 48.3% of the patients had at least a 90.0% decrease in seizure frequency, and 50.0% of these patients presented total seizure remission. At 12 months, eight patients continued to show positive results, and seven of these children remained on the ketogenic diet for 24 months. There was an improvement of the nutritional status at 24 months, especially in terms of weight, which culminated with the recovery of proper weight-for-height. There were no significant changes in biochemical indices (total cholesterol and components, triglycerides, albumin, total protein, creatinine, glycemia, serum aspartate transaminase andserum alanine transaminase). Serum cholesterol levels increased significantly in the first month, fell in the following six months, and remained within the normal limits thereafter. ConclusionIn conclusion, patients on the classic ketogenic diet for at least 24 months gained weight. Moreover, approximately one third of the patients achieved significant reduction in seizure frequency, and some patients achieved total remission. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9288 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9288 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9288/6667 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 25 No. 5 (2012): Revista de Nutrição Revista de Nutrição; Vol. 25 Núm. 5 (2012): Revista de Nutrição Revista de Nutrição; v. 25 n. 5 (2012): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
_version_ |
1799126072531353600 |