Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity

Detalhes bibliográficos
Autor(a) principal: Soriano FRASSETTO, Silvana
Data de Publicação: 2023
Outros Autores: Oliveira de BITENCOURT, Graziela
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9526
Resumo: Recent studies have demonstrated a direct relationship between leptin and the regulation of energy balance, and as a factor involved in eating disorders. Acting on the central nervous system, leptin affects food intake, glucose metabolism, body weight, the production of sexual hormones, and physical activity. Studies with humans and animals indicate that low leptin levels are related to symptoms of anorexia nervosa: low food intake, excessive loss of body weight, amenorrhea and hyperactivity. Thus, the degree of hypoleptinemia is not only a strong indication of low reserves of adipose tissue, but also of a severe disorder, and leptin levels canbe used to better evaluate the seriousness of the disease. Research has aimed to study the use of leptin in the treatment of patients with AN, and positive results have been obtained in the reduction of hyperactivity. It is possible that leptin treatment associated with medication and psychotherapy can be beneficial for extremely active anorexia nervosa patients, making them more susceptible to further treatment. Adequate food intake, medication, psychotherapy, and a comfortable environment during leptin treatment should be ensured. Thus, this article aims to describe leptin and aspects related to anorexia, and discuss how this information can beimportant in the clinical evaluation of patients with this eating disorder.
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spelling Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivityAspectos da leptina na anorexia nervosa: possíveis efeitos benéficos no tratamento da hiperatividadeAnorexia nervosaHyperkinesisHormones. LeptinAdipose tissueAnorexia nervosaHipercineseHormôniosLeptinaTecido adiposoRecent studies have demonstrated a direct relationship between leptin and the regulation of energy balance, and as a factor involved in eating disorders. Acting on the central nervous system, leptin affects food intake, glucose metabolism, body weight, the production of sexual hormones, and physical activity. Studies with humans and animals indicate that low leptin levels are related to symptoms of anorexia nervosa: low food intake, excessive loss of body weight, amenorrhea and hyperactivity. Thus, the degree of hypoleptinemia is not only a strong indication of low reserves of adipose tissue, but also of a severe disorder, and leptin levels canbe used to better evaluate the seriousness of the disease. Research has aimed to study the use of leptin in the treatment of patients with AN, and positive results have been obtained in the reduction of hyperactivity. It is possible that leptin treatment associated with medication and psychotherapy can be beneficial for extremely active anorexia nervosa patients, making them more susceptible to further treatment. Adequate food intake, medication, psychotherapy, and a comfortable environment during leptin treatment should be ensured. Thus, this article aims to describe leptin and aspects related to anorexia, and discuss how this information can beimportant in the clinical evaluation of patients with this eating disorder.Pesquisas recentes demonstram a relação direta da leptina na regulação do balanço energético e como um dos fatores envolvidos em transtornos alimentares. Com ação no sistema nervoso central, a leptina interfere na ingestão alimentar, no metabolismo da glicose, no peso corporal, na produção de hormônios sexuais e na atividade física. As pesquisas realizadas tanto em seres humanos como em animais demonstram que a queda nos níveis de leptina está relacionada aos sintomas apresentados na anorexia nervosa: a baixa ingestão alimentar, a perda excessiva de peso corporal, a amenorréia e a hiperatividade. Assim, o grau de hipoleptinemia não é apenas uma forte indicação de baixa reserva de tecido adiposo, mas também de severa desordem, sendo que os níveis de leptina podem ser utilizados para avaliar melhor a gravidade da doença. Pesquisas estão sendo realizadas com o objetivo de discutir a possibilidade de utilização da leptina como coadjuvante no tratamento de pacientes com anorexia nervosa para a diminuição da hiperatividade. Acredita-se que o tratamento com leptina associado à medicação e à psicoterapia, poderia ser benéfico em pacientes anoréxicas extremamente ativas, deixando-as mais suscetíveis ao tratamento adicional. Uma realimentação suficiente, a medicação, a psicoterapia e um ambiente acolhedor durante o tratamento com leptina devem ser assegurados. Assim, este artigo tem como objetivo discorrer sobre a leptina e aspectos relacionados à anorexia, e discutir como esta informação pode ser importante na avaliação clínica de pacientes com este transtorno alimentar. Núcleo de Editoração – PUC-Campinas2023-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9526Brazilian Journal of Nutrition; Vol. 22 No. 5 (2009): Revista de NutriçãoRevista de Nutrição; Vol. 22 Núm. 5 (2009): Revista de NutriçãoRevista de Nutrição; v. 22 n. 5 (2009): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9526/6892Copyright (c) 2023 Silvana Soriano FRASSETTO, Graziela Oliveira de BITENCOURThttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSoriano FRASSETTO, SilvanaOliveira de BITENCOURT, Graziela 2023-12-05T14:43:42Zoai:ojs.periodicos.puc-campinas.edu.br:article/9526Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-12-05T14:43:42Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
Aspectos da leptina na anorexia nervosa: possíveis efeitos benéficos no tratamento da hiperatividade
title Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
spellingShingle Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
Soriano FRASSETTO, Silvana
Anorexia nervosa
Hyperkinesis
Hormones. Leptin
Adipose tissue
Anorexia nervosa
Hipercinese
Hormônios
Leptina
Tecido adiposo
title_short Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
title_full Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
title_fullStr Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
title_full_unstemmed Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
title_sort Aspects of leptin in anorexia nervosa: possible beneficial effects on the treatment of hyperactivity
author Soriano FRASSETTO, Silvana
author_facet Soriano FRASSETTO, Silvana
Oliveira de BITENCOURT, Graziela
author_role author
author2 Oliveira de BITENCOURT, Graziela
author2_role author
dc.contributor.author.fl_str_mv Soriano FRASSETTO, Silvana
Oliveira de BITENCOURT, Graziela
dc.subject.por.fl_str_mv Anorexia nervosa
Hyperkinesis
Hormones. Leptin
Adipose tissue
Anorexia nervosa
Hipercinese
Hormônios
Leptina
Tecido adiposo
topic Anorexia nervosa
Hyperkinesis
Hormones. Leptin
Adipose tissue
Anorexia nervosa
Hipercinese
Hormônios
Leptina
Tecido adiposo
description Recent studies have demonstrated a direct relationship between leptin and the regulation of energy balance, and as a factor involved in eating disorders. Acting on the central nervous system, leptin affects food intake, glucose metabolism, body weight, the production of sexual hormones, and physical activity. Studies with humans and animals indicate that low leptin levels are related to symptoms of anorexia nervosa: low food intake, excessive loss of body weight, amenorrhea and hyperactivity. Thus, the degree of hypoleptinemia is not only a strong indication of low reserves of adipose tissue, but also of a severe disorder, and leptin levels canbe used to better evaluate the seriousness of the disease. Research has aimed to study the use of leptin in the treatment of patients with AN, and positive results have been obtained in the reduction of hyperactivity. It is possible that leptin treatment associated with medication and psychotherapy can be beneficial for extremely active anorexia nervosa patients, making them more susceptible to further treatment. Adequate food intake, medication, psychotherapy, and a comfortable environment during leptin treatment should be ensured. Thus, this article aims to describe leptin and aspects related to anorexia, and discuss how this information can beimportant in the clinical evaluation of patients with this eating disorder.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9526
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9526
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9526/6892
dc.rights.driver.fl_str_mv Copyright (c) 2023 Silvana Soriano FRASSETTO, Graziela Oliveira de BITENCOURT
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Silvana Soriano FRASSETTO, Graziela Oliveira de BITENCOURT
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 22 No. 5 (2009): Revista de Nutrição
Revista de Nutrição; Vol. 22 Núm. 5 (2009): Revista de Nutrição
Revista de Nutrição; v. 22 n. 5 (2009): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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