Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista odonto ciência (Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802 |
Resumo: | Tobacco and alcohol are the main extrinsic etiological factors for the genesis of oral squamous cell carcinoma (SCC), but it is still not clear if the presence of these factors interfere with clinical, pathologic and molecular characteristics or with the prognosis of the disease. In the present study, these characteristics were reviewed, establishing comparisons between the lesions of patients exposed and not exposed to tobacco and alcohol. We observed that oral SCC in non smokers and non alcohol drinkers occur mainly in female patients, under 50 or over 70 years old. The lesions tend to be less aggressive in this group of patients and have a better prognosis. The molecular characteristics of these malignant tumors also appear to be influenced by the presence of these habits, once mutations of p53 have been associated with tobacco and alcohol use. The understanding of the differences between the neoplasms of these two groups of patients can contribute to the management of this cancer, which could lead to advances in the determination of more appropriate therapeutic measures. |
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Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcoholCaracterísticas do carcinoma bucal de células escamosas em usuários ou não usuários de tabaco e álcoolOral cancerrisk factorsprognosisOral CancerCâncer bucalfatores de riscoprognósticoCâncer bucalTobacco and alcohol are the main extrinsic etiological factors for the genesis of oral squamous cell carcinoma (SCC), but it is still not clear if the presence of these factors interfere with clinical, pathologic and molecular characteristics or with the prognosis of the disease. In the present study, these characteristics were reviewed, establishing comparisons between the lesions of patients exposed and not exposed to tobacco and alcohol. We observed that oral SCC in non smokers and non alcohol drinkers occur mainly in female patients, under 50 or over 70 years old. The lesions tend to be less aggressive in this group of patients and have a better prognosis. The molecular characteristics of these malignant tumors also appear to be influenced by the presence of these habits, once mutations of p53 have been associated with tobacco and alcohol use. The understanding of the differences between the neoplasms of these two groups of patients can contribute to the management of this cancer, which could lead to advances in the determination of more appropriate therapeutic measures.O tabaco e o álcool são os principais fatores etiológicos extrínsecos associados à gênese do carcinoma bucal de células escamosas (CCE), mas não está claro se estes fatores interferem nas características clínico-patológicas, moleculares ou no prognóstico da doença. No presente estudo, essas características foram revisadas, estabelecendo-se comparações entre as lesões de pacientes usuários ou não de tabaco e álcool. Observou-se que carcinomas bucais de não fumantes e não etilistas ocorrem, preferencialmente, em pacientes do sexo feminino, em faixa etária inferior a 50 ou superior 70 anos. Neste grupo de indivíduos, as lesões tendem a ser menos agressivas e apresentam melhor prognóstico. O tabagismo e o etilismo também parecem influenciar as características moleculares do carcinoma bucal, uma vez que mutações da proteína p53 nas lesões têm sido associadas a esses fatores de risco. A compreensão das diferenças entre os CCE bucais desses dois grupos de pacientes pode contribuir para uma melhor abordagem e avanços no desenvolvimento de medidas terapêuticas mais adequadas frente a esta neoplasia.EDIPUCRS - Editora Universitária da PUCRS2011-12-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.Revisão de literaturainfo:eu-repo/semantics/otherapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802Revista Odonto Ciência; Vol. 27 No. 1 (2012); 69 - 73Revista Odonto Ciência; v. 27 n. 1 (2012); 69 - 731980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802/7690Scheidt, Juliana Hintz GermanosYurgel, Liliane SoaresCherubini, KarenFigueiredo, Maria Antonia ZancanaroSalum, Fernanda Gonçalvesinfo:eu-repo/semantics/openAccess2013-11-11T11:36:13Zoai:ojs.revistaseletronicas.pucrs.br:article/9802Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T11:36:13Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol Características do carcinoma bucal de células escamosas em usuários ou não usuários de tabaco e álcool |
title |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol |
spellingShingle |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol Scheidt, Juliana Hintz Germanos Oral cancer risk factors prognosis Oral Cancer Câncer bucal fatores de risco prognóstico Câncer bucal |
title_short |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol |
title_full |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol |
title_fullStr |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol |
title_full_unstemmed |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol |
title_sort |
Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol |
author |
Scheidt, Juliana Hintz Germanos |
author_facet |
Scheidt, Juliana Hintz Germanos Yurgel, Liliane Soares Cherubini, Karen Figueiredo, Maria Antonia Zancanaro Salum, Fernanda Gonçalves |
author_role |
author |
author2 |
Yurgel, Liliane Soares Cherubini, Karen Figueiredo, Maria Antonia Zancanaro Salum, Fernanda Gonçalves |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Scheidt, Juliana Hintz Germanos Yurgel, Liliane Soares Cherubini, Karen Figueiredo, Maria Antonia Zancanaro Salum, Fernanda Gonçalves |
dc.subject.por.fl_str_mv |
Oral cancer risk factors prognosis Oral Cancer Câncer bucal fatores de risco prognóstico Câncer bucal |
topic |
Oral cancer risk factors prognosis Oral Cancer Câncer bucal fatores de risco prognóstico Câncer bucal |
description |
Tobacco and alcohol are the main extrinsic etiological factors for the genesis of oral squamous cell carcinoma (SCC), but it is still not clear if the presence of these factors interfere with clinical, pathologic and molecular characteristics or with the prognosis of the disease. In the present study, these characteristics were reviewed, establishing comparisons between the lesions of patients exposed and not exposed to tobacco and alcohol. We observed that oral SCC in non smokers and non alcohol drinkers occur mainly in female patients, under 50 or over 70 years old. The lesions tend to be less aggressive in this group of patients and have a better prognosis. The molecular characteristics of these malignant tumors also appear to be influenced by the presence of these habits, once mutations of p53 have been associated with tobacco and alcohol use. The understanding of the differences between the neoplasms of these two groups of patients can contribute to the management of this cancer, which could lead to advances in the determination of more appropriate therapeutic measures. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article. Invited Article. Revisão de literatura info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802 |
url |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802/7690 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
dc.source.none.fl_str_mv |
Revista Odonto Ciência; Vol. 27 No. 1 (2012); 69 - 73 Revista Odonto Ciência; v. 27 n. 1 (2012); 69 - 73 1980-6523 0102-9460 reponame:Revista odonto ciência (Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Revista odonto ciência (Online) |
collection |
Revista odonto ciência (Online) |
repository.name.fl_str_mv |
Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
||odontociencia@pucrs.br |
_version_ |
1754820875902779392 |