Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista odonto ciência (Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/13114 |
Resumo: | Objectives: A medicated chewing gum is a solid, single-dose preparation intended to be chewed for a certain period of time and deliver the drug. It may contain one or more than one active pharmaceutical ingredient. Whithin this context, we formulated a medicated gum with three active pharmaceutical ingredients: Camphor, p-chlorophenol and hydrogen peroxide, to be evaluated as therapeutic agents in dental caries. The aim of this study was to compare the effects on salivary streptococcus mutans, pH, buffer capacity and secretion rate of three medicated gums containing chlorophenol / hydrogen peroxide, xylitol or chlorhexidine.Methods: Double-blind, randomized crossover treatment in 24 subjects. The patients were randomized and subjected to six different treatment sequences. The subjects used, 1 gum tablet three times a day for 20 minutes, morning, noon and night. At the beginning and end of the three experimental phases saliva samples were obtained for determining the pH, buffer capacity, salivary flow rate and quantitative enumeration of S. mutans.Results: The use of medicated gum with camphor/p-chlorophenol and hydrogen peroxide did not modify the salivary chemical parameters measured, and not significantly reduced the number of S. mutans, after 7 days. Chewing gums with chlorhexidine significantly reduced the quantitative counting of S. mutans salivary and flow rate in a period of 7 days.Conclusions: The use of medicated chewing gums based on camphor / p chlorophenol and hydrogen peroxide does not alter the chemical salivary parameters and does not significantly reduce the number of S. mutans, after a use over a period of 7 days. |
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Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scoresEfeito de gomas de mascar contendo clorofenol / peróxido de hidrogênio, xilitol ou clorexidina no fluxo salivar, pH, capacidade tampão e escores salivares de Streptococcus mutansMedicated Chewing GumCamphorp-ChlorophenolHydrogen PeroxideSalivachlorhexidinexylitol.Objectives: A medicated chewing gum is a solid, single-dose preparation intended to be chewed for a certain period of time and deliver the drug. It may contain one or more than one active pharmaceutical ingredient. Whithin this context, we formulated a medicated gum with three active pharmaceutical ingredients: Camphor, p-chlorophenol and hydrogen peroxide, to be evaluated as therapeutic agents in dental caries. The aim of this study was to compare the effects on salivary streptococcus mutans, pH, buffer capacity and secretion rate of three medicated gums containing chlorophenol / hydrogen peroxide, xylitol or chlorhexidine.Methods: Double-blind, randomized crossover treatment in 24 subjects. The patients were randomized and subjected to six different treatment sequences. The subjects used, 1 gum tablet three times a day for 20 minutes, morning, noon and night. At the beginning and end of the three experimental phases saliva samples were obtained for determining the pH, buffer capacity, salivary flow rate and quantitative enumeration of S. mutans.Results: The use of medicated gum with camphor/p-chlorophenol and hydrogen peroxide did not modify the salivary chemical parameters measured, and not significantly reduced the number of S. mutans, after 7 days. Chewing gums with chlorhexidine significantly reduced the quantitative counting of S. mutans salivary and flow rate in a period of 7 days.Conclusions: The use of medicated chewing gums based on camphor / p chlorophenol and hydrogen peroxide does not alter the chemical salivary parameters and does not significantly reduce the number of S. mutans, after a use over a period of 7 days.Objetivos: Gomas de mascar medicadas são preparações sólidas, de dose única, que devem ser mastigadas por um determinado período de tempo a fim de que um ou mais agentes farmacológicos sejam admnistrados. Neste contexto, gomas de mascar medicadas com três ingredientes farmacêuticos ativos – cânfora, p-clorofenol e peróxido de hidrogênio – foram avaliadas como agentes terapêuticos para cárie dentária. O objetivo deste estúdio foi comparar o efeito de gomas de mascar contendo chlorophenol / peróxido de hidrogênio, xilitol ou clorexidina sobre Streptococos mutans salivares, pH, capacidade tampão, a taxa de secreção salivar.Métodos: Foi realizado estudo duplo-cego, com deliamento de randomização cruzada de tratamento em 24 pacientes. Esses foram submetidos a seis sequências diferentes de tratamento. Gomas de mascar foram administradas três vezes ao dia durante 20 minutos, pela manhã, tarde e noite. No início e no final das três fases de amostras de saliva experimentais foram obtidas para a determinação de pH, capacidade tampão, fluxo salivar e enumeração quantitativa de S. mutans.Resultados: O uso de goma medicado de cânfora com p-clorofenol e peróxido de hidrogénio não modificaram os parâmetros químicos salivares medidos, e reduziram o número de S. mutans, após 7 dias. Gomas de mascar contendo clorexidina reduziram significativamente a contagem quantitativa de S. mutans e a taxa de fluxo salivar em um período de 7 dias.Conclusões: O uso de gomas de mascar medicadas com base de cânfora / p clorofenol ou com peróxido de hidrogênio não altera significativamente os parâmetros químicos salivares e não reduz significativamente o número de S. mutans após a utilização por período de 7 dias.EDIPUCRS - Editora Universitária da PUCRS2015-07-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleRandomized, double-blind, randomized crossoverapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/1311410.15448/1980-6523.2014.3.13114Revista Odonto Ciência; Vol. 29 No. 3 (2014); 81-86Revista Odonto Ciência; v. 29 n. 3 (2014); 81-861980-65230102-946010.15448/1980-6523.2014.3reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/13114/13372Copyright (c) 2015 Revista Odonto Ciência (Journal of Dental Science)info:eu-repo/semantics/openAccessYévenes, IsmaelZamanillo, Carmen Gloria TorresFluxá, Patricia PalmaRamirez, Marta GajardoMaass, PaulaQuintana, Renata2015-10-21T16:34:59Zoai:ojs.revistaseletronicas.pucrs.br:article/13114Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2015-10-21T16:34:59Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores Efeito de gomas de mascar contendo clorofenol / peróxido de hidrogênio, xilitol ou clorexidina no fluxo salivar, pH, capacidade tampão e escores salivares de Streptococcus mutans |
title |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores |
spellingShingle |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores Yévenes, Ismael Medicated Chewing Gum Camphor p-Chlorophenol Hydrogen Peroxide Saliva chlorhexidine xylitol. |
title_short |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores |
title_full |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores |
title_fullStr |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores |
title_full_unstemmed |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores |
title_sort |
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores |
author |
Yévenes, Ismael |
author_facet |
Yévenes, Ismael Zamanillo, Carmen Gloria Torres Fluxá, Patricia Palma Ramirez, Marta Gajardo Maass, Paula Quintana, Renata |
author_role |
author |
author2 |
Zamanillo, Carmen Gloria Torres Fluxá, Patricia Palma Ramirez, Marta Gajardo Maass, Paula Quintana, Renata |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Yévenes, Ismael Zamanillo, Carmen Gloria Torres Fluxá, Patricia Palma Ramirez, Marta Gajardo Maass, Paula Quintana, Renata |
dc.subject.por.fl_str_mv |
Medicated Chewing Gum Camphor p-Chlorophenol Hydrogen Peroxide Saliva chlorhexidine xylitol. |
topic |
Medicated Chewing Gum Camphor p-Chlorophenol Hydrogen Peroxide Saliva chlorhexidine xylitol. |
description |
Objectives: A medicated chewing gum is a solid, single-dose preparation intended to be chewed for a certain period of time and deliver the drug. It may contain one or more than one active pharmaceutical ingredient. Whithin this context, we formulated a medicated gum with three active pharmaceutical ingredients: Camphor, p-chlorophenol and hydrogen peroxide, to be evaluated as therapeutic agents in dental caries. The aim of this study was to compare the effects on salivary streptococcus mutans, pH, buffer capacity and secretion rate of three medicated gums containing chlorophenol / hydrogen peroxide, xylitol or chlorhexidine.Methods: Double-blind, randomized crossover treatment in 24 subjects. The patients were randomized and subjected to six different treatment sequences. The subjects used, 1 gum tablet three times a day for 20 minutes, morning, noon and night. At the beginning and end of the three experimental phases saliva samples were obtained for determining the pH, buffer capacity, salivary flow rate and quantitative enumeration of S. mutans.Results: The use of medicated gum with camphor/p-chlorophenol and hydrogen peroxide did not modify the salivary chemical parameters measured, and not significantly reduced the number of S. mutans, after 7 days. Chewing gums with chlorhexidine significantly reduced the quantitative counting of S. mutans salivary and flow rate in a period of 7 days.Conclusions: The use of medicated chewing gums based on camphor / p chlorophenol and hydrogen peroxide does not alter the chemical salivary parameters and does not significantly reduce the number of S. mutans, after a use over a period of 7 days. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Randomized, double-blind, randomized crossover |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/13114 10.15448/1980-6523.2014.3.13114 |
url |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/13114 |
identifier_str_mv |
10.15448/1980-6523.2014.3.13114 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/13114/13372 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2015 Revista Odonto Ciência (Journal of Dental Science) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2015 Revista Odonto Ciência (Journal of Dental Science) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
publisher.none.fl_str_mv |
EDIPUCRS - Editora Universitária da PUCRS |
dc.source.none.fl_str_mv |
Revista Odonto Ciência; Vol. 29 No. 3 (2014); 81-86 Revista Odonto Ciência; v. 29 n. 3 (2014); 81-86 1980-6523 0102-9460 10.15448/1980-6523.2014.3 reponame:Revista odonto ciência (Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Revista odonto ciência (Online) |
collection |
Revista odonto ciência (Online) |
repository.name.fl_str_mv |
Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
||odontociencia@pucrs.br |
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1754820876458524672 |