Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]

Detalhes bibliográficos
Autor(a) principal: Flórez, Paloma Borges
Data de Publicação: 2006
Outros Autores: Bender, Ana Ligia, D’angelo, A., Staub, Henrique Luiz
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571
Resumo: Objective: This article describes the autoantibody profile using rat kidney-stomach substrate in a tertiary center in a year period. Material and methods: The design was a case series, being results obtained from the data bank of the Immunology Section of the Clinical Pathology Laboratory of Saint Lucas Hospital of PUCRS. Results: In 262 patients (68% females) previosly selected by clinical trial, we evaluated the antibody profile in rat kidney-stomach substrate by indirect immunofluorescence. Anti-smooth muscle antibodies predominated (31%), followed by anti-reticulin antibodies (27%), antimitochondrial antibodies (24%), anti-gastric parietal cells antibodies (21%), anti-”brush border” antibodies (4%) and liver-kidney microsome antibodies (0.4%). The majority of patients with a positive test for anti-smooth muscle antibodies had titers below 1/80 (cutoff for autoimmune hepatitis). Anti-ribosome antibodies were not detected in any patient. Apart from the liverkidney microsome antibody (seen in one male), a female predominance was observed for the other autoantibodies described; this predominance, nevertheless, was statistically significant only for antimitochondrial antibodies (P = 0.04). Conclusion: This finding corroborates a possible relationship of genetic and hormonal factors in autoimmunity. KEY WORDS: SUBSTRATES; KIDNEY; STOMACH; RATS; AUTOANTIBODIES; MUSCLE, SMOOTH; MITOCHONDRIA, MUSCLE; ANTIBODIES; RETICULIN/immunology; HEPATITIS, AUTOIMMUNE; LIVER CIRRHOSIS, BILIARY.
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spelling Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]Perfil de auto-anticorpos detectados em substrato rim-estômago de rato no Hospital São Lucas da PUCRSObjective: This article describes the autoantibody profile using rat kidney-stomach substrate in a tertiary center in a year period. Material and methods: The design was a case series, being results obtained from the data bank of the Immunology Section of the Clinical Pathology Laboratory of Saint Lucas Hospital of PUCRS. Results: In 262 patients (68% females) previosly selected by clinical trial, we evaluated the antibody profile in rat kidney-stomach substrate by indirect immunofluorescence. Anti-smooth muscle antibodies predominated (31%), followed by anti-reticulin antibodies (27%), antimitochondrial antibodies (24%), anti-gastric parietal cells antibodies (21%), anti-”brush border” antibodies (4%) and liver-kidney microsome antibodies (0.4%). The majority of patients with a positive test for anti-smooth muscle antibodies had titers below 1/80 (cutoff for autoimmune hepatitis). Anti-ribosome antibodies were not detected in any patient. Apart from the liverkidney microsome antibody (seen in one male), a female predominance was observed for the other autoantibodies described; this predominance, nevertheless, was statistically significant only for antimitochondrial antibodies (P = 0.04). Conclusion: This finding corroborates a possible relationship of genetic and hormonal factors in autoimmunity. KEY WORDS: SUBSTRATES; KIDNEY; STOMACH; RATS; AUTOANTIBODIES; MUSCLE, SMOOTH; MITOCHONDRIA, MUSCLE; ANTIBODIES; RETICULIN/immunology; HEPATITIS, AUTOIMMUNE; LIVER CIRRHOSIS, BILIARY. Objetivo:O trabalho descreve o perfil de autoanticorpos utilizando-se o substrato rim-estômago de rato em um centro de saúde terciário no período de um ano. Material e métodos: O estudo foi de série de casos, com dados obtidos do banco de dados do Setor de Imunologia do Laboratório de Patologia Clínica do Hospital São Lucas da PUCRS. Resultados: Em 262 pacientes (68% do sexo feminino) previamente selecionados por triagem clínica, avaliou-se o perfil de auto-anticorpos em substrato rim-estômago de rato através de imunofluorescência indireta. Anticorpos antimúsculo liso prevaleceram (31%), seguidos por anticorpos anti-reticulina (27%), anticorpos antimitocondriais (24%), anticélulas parietais gástricas (21%), anticorpos anti-”brush border” (4%) e antiLKM (liver-kidney microsome) (0,4%). A maioria dos pacientes com teste positivo para anticorpos antimúsculo liso cursou com titulações inferiores a 1/80 (ponto de corte para hepatite auto-imune). Anticorpos anti-ribossomais não foram detectados em quaisquer pacientes. À exceção do anticorpo antiLKM (presente apenas em um caso, sexo masculino), observou-se predominância do sexo feminino nos auto-anticorpos analisados; tal predomínio, entretanto, só alcançou significância estatística para anticorpos antimitocondriais (P = 0,04). Conclusão: O achado corrobora a possível relação entre fatores genéticos e hormonais na auto-imunidade. UNITERMOS: SUBSTRATOS; RIM; ESTÔMAGO; RATOS; AUTO-ANTICORPOS; ANTICORPOS; MÚSCULO LISO; MITOCÔNDRIA MUSCULAR; RETICULINA/imunologia; HEPATITE AUTO-IMUNE; CIRROSE HEPÁTICA BILIAR. Editora da PUCRS - ediPUCRS2006-10-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571Scientia Medica; Vol. 15 No. 4 (2005)Scientia Medica; v. 15 n. 4 (2005)1980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571/1174https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571/7926Flórez, Paloma BorgesBender, Ana LigiaD’angelo, A.Staub, Henrique Luizinfo:eu-repo/semantics/openAccess2012-06-25T15:44:15Zoai:ojs.revistaseletronicas.pucrs.br:article/1571Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2012-06-25T15:44:15Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
Perfil de auto-anticorpos detectados em substrato rim-estômago de rato no Hospital São Lucas da PUCRS
title Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
spellingShingle Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
Flórez, Paloma Borges
title_short Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
title_full Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
title_fullStr Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
title_full_unstemmed Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
title_sort Autoantibody profile in rat kidney-stomach substrate in the São Lucas Hospital of PUCRS [Abstract in English]
author Flórez, Paloma Borges
author_facet Flórez, Paloma Borges
Bender, Ana Ligia
D’angelo, A.
Staub, Henrique Luiz
author_role author
author2 Bender, Ana Ligia
D’angelo, A.
Staub, Henrique Luiz
author2_role author
author
author
dc.contributor.author.fl_str_mv Flórez, Paloma Borges
Bender, Ana Ligia
D’angelo, A.
Staub, Henrique Luiz
description Objective: This article describes the autoantibody profile using rat kidney-stomach substrate in a tertiary center in a year period. Material and methods: The design was a case series, being results obtained from the data bank of the Immunology Section of the Clinical Pathology Laboratory of Saint Lucas Hospital of PUCRS. Results: In 262 patients (68% females) previosly selected by clinical trial, we evaluated the antibody profile in rat kidney-stomach substrate by indirect immunofluorescence. Anti-smooth muscle antibodies predominated (31%), followed by anti-reticulin antibodies (27%), antimitochondrial antibodies (24%), anti-gastric parietal cells antibodies (21%), anti-”brush border” antibodies (4%) and liver-kidney microsome antibodies (0.4%). The majority of patients with a positive test for anti-smooth muscle antibodies had titers below 1/80 (cutoff for autoimmune hepatitis). Anti-ribosome antibodies were not detected in any patient. Apart from the liverkidney microsome antibody (seen in one male), a female predominance was observed for the other autoantibodies described; this predominance, nevertheless, was statistically significant only for antimitochondrial antibodies (P = 0.04). Conclusion: This finding corroborates a possible relationship of genetic and hormonal factors in autoimmunity. KEY WORDS: SUBSTRATES; KIDNEY; STOMACH; RATS; AUTOANTIBODIES; MUSCLE, SMOOTH; MITOCHONDRIA, MUSCLE; ANTIBODIES; RETICULIN/immunology; HEPATITIS, AUTOIMMUNE; LIVER CIRRHOSIS, BILIARY.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571/1174
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1571/7926
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 15 No. 4 (2005)
Scientia Medica; v. 15 n. 4 (2005)
1980-6108
1806-5562
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
_version_ 1809101748396097536

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