Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19

Detalhes bibliográficos
Autor(a) principal: Hosseinzadeh, Mofid
Data de Publicação: 2022
Outros Autores: Pouladzadeh, Mandana, Eftekhar, Amin, Choghakabodi, Parastoo Moradi, Sokooti, Alireza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281
Resumo: Objective: To verify D-dimer values to predict disease severity, degree of lung involvement and mortality in patients with COVID-19. Method: The D-dimer levels of 200 confirmed COVID-19 patients were prospectively measured in the Emergency Department of Razi Hospital of Ahvaz on the admission day, and its relations with the illness severity, computed tomography (CT) score, and mortality were assessed. Results: D-dimer level > 1.04 μg/mL and ≤ 1.12 μg/mL could indicate severe illness and high grade of pulmonary involvement but low risk of death. The mortality rate in the patients with D-dimer level > 1.12 μg/mL (was significantly higher than its rate in those with D-dimer level ≤ 1.12 μg/mL (17.2% x 1.5%; P:0.02). An independent positive correlation was found between D-dimer and Chest CT score as well as the disease severity (OR: 1.84; 95%CI:1.38 - 2.45; P:0.0001). Conclusion: D-dimer level > 1.12 μg/mL on the early stage of COVID-19 infection may independently predict the severe illness, high grade of pulmonary involvement, and high risk of death, indicating its beneficial role in timely management of critical patients.
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spelling Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19Avaliação do D-dímero como preditor de gravidade, grau de envolvimento pulmonar e mortalidade em pacientes com COVID-19COVID-19D-dimerDisease SeverityPulmonary involvementMortalityCOVID-19D-dímeroGravidade da doençadoença pulmonarMortalidadeObjective: To verify D-dimer values to predict disease severity, degree of lung involvement and mortality in patients with COVID-19. Method: The D-dimer levels of 200 confirmed COVID-19 patients were prospectively measured in the Emergency Department of Razi Hospital of Ahvaz on the admission day, and its relations with the illness severity, computed tomography (CT) score, and mortality were assessed. Results: D-dimer level > 1.04 μg/mL and ≤ 1.12 μg/mL could indicate severe illness and high grade of pulmonary involvement but low risk of death. The mortality rate in the patients with D-dimer level > 1.12 μg/mL (was significantly higher than its rate in those with D-dimer level ≤ 1.12 μg/mL (17.2% x 1.5%; P:0.02). An independent positive correlation was found between D-dimer and Chest CT score as well as the disease severity (OR: 1.84; 95%CI:1.38 - 2.45; P:0.0001). Conclusion: D-dimer level > 1.12 μg/mL on the early stage of COVID-19 infection may independently predict the severe illness, high grade of pulmonary involvement, and high risk of death, indicating its beneficial role in timely management of critical patients.Objetivo: Verificar os valores do D-dímero para predizer a gravidade da doença, o grau de envolvimento pulmonar e a mortalidade em pacientes com COVID-19.Método: Os níveis de dímero D de 200 pacientes confirmados com COVID-19 foram medidos, prospectivamente, no Departamento de Emergência do Hospital Razi de Ahvaz, no dia da admissão, e suas relações com a gravidade da doença, escore de tomografia computadorizada (CT) e mortalidade foram avaliadas. Resultados: Os níveis do D-dímero > 1,04 μg/mL e ≤ 1,12 μg/mL podem indicar doença grave e alto grau de envolvimento pulmonar, mas baixo risco de morte. A taxa de mortalidade nos pacientes com valor de D-dímero > 1,12 μg/mL foi significativamente maior do naqueles com nível de D-dímero ≤ 1,12 μg/mL (17,2% x 1,5%; P:0,02). Foi encontrada uma correlação positiva independente entre o D-dímero e o escore de CT de tórax e a gravidade da doença (OR: 1,84; IC 95%:1,38 - 2,45; P:0,0001). Conclusão: O nível do D-dímero > 1,12 μg/mL no estágio inicial da infecção por COVID-19 pode prever independentemente a doença grave, alto grau de envolvimento pulmonar e alto risco de morte, indicando seu papel benéfico no manejo oportuno de pacientes críticos.Editora da PUCRS - ediPUCRS2022-10-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/4328110.15448/1980-6108.2022.1.43281Scientia Medica; Vol. 32 No. 1 (2022): Single Volume; e43281Scientia Medica; v. 32 n. 1 (2022): Volume Único; e432811980-61081806-556210.15448/1980-6108.2022.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281/27684Copyright (c) 2022 Scientia Medicahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessHosseinzadeh, MofidPouladzadeh, MandanaEftekhar, AminChoghakabodi, Parastoo MoradiSokooti, Alireza2022-12-16T12:09:43Zoai:ojs.revistaseletronicas.pucrs.br:article/43281Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2022-12-16T12:09:43Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
Avaliação do D-dímero como preditor de gravidade, grau de envolvimento pulmonar e mortalidade em pacientes com COVID-19
title Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
spellingShingle Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
Hosseinzadeh, Mofid
COVID-19
D-dimer
Disease Severity
Pulmonary involvement
Mortality
COVID-19
D-dímero
Gravidade da doença
doença pulmonar
Mortalidade
title_short Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
title_full Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
title_fullStr Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
title_full_unstemmed Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
title_sort Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
author Hosseinzadeh, Mofid
author_facet Hosseinzadeh, Mofid
Pouladzadeh, Mandana
Eftekhar, Amin
Choghakabodi, Parastoo Moradi
Sokooti, Alireza
author_role author
author2 Pouladzadeh, Mandana
Eftekhar, Amin
Choghakabodi, Parastoo Moradi
Sokooti, Alireza
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Hosseinzadeh, Mofid
Pouladzadeh, Mandana
Eftekhar, Amin
Choghakabodi, Parastoo Moradi
Sokooti, Alireza
dc.subject.por.fl_str_mv COVID-19
D-dimer
Disease Severity
Pulmonary involvement
Mortality
COVID-19
D-dímero
Gravidade da doença
doença pulmonar
Mortalidade
topic COVID-19
D-dimer
Disease Severity
Pulmonary involvement
Mortality
COVID-19
D-dímero
Gravidade da doença
doença pulmonar
Mortalidade
description Objective: To verify D-dimer values to predict disease severity, degree of lung involvement and mortality in patients with COVID-19. Method: The D-dimer levels of 200 confirmed COVID-19 patients were prospectively measured in the Emergency Department of Razi Hospital of Ahvaz on the admission day, and its relations with the illness severity, computed tomography (CT) score, and mortality were assessed. Results: D-dimer level > 1.04 μg/mL and ≤ 1.12 μg/mL could indicate severe illness and high grade of pulmonary involvement but low risk of death. The mortality rate in the patients with D-dimer level > 1.12 μg/mL (was significantly higher than its rate in those with D-dimer level ≤ 1.12 μg/mL (17.2% x 1.5%; P:0.02). An independent positive correlation was found between D-dimer and Chest CT score as well as the disease severity (OR: 1.84; 95%CI:1.38 - 2.45; P:0.0001). Conclusion: D-dimer level > 1.12 μg/mL on the early stage of COVID-19 infection may independently predict the severe illness, high grade of pulmonary involvement, and high risk of death, indicating its beneficial role in timely management of critical patients.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281
10.15448/1980-6108.2022.1.43281
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281
identifier_str_mv 10.15448/1980-6108.2022.1.43281
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281/27684
dc.rights.driver.fl_str_mv Copyright (c) 2022 Scientia Medica
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Scientia Medica
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 32 No. 1 (2022): Single Volume; e43281
Scientia Medica; v. 32 n. 1 (2022): Volume Único; e43281
1980-6108
1806-5562
10.15448/1980-6108.2022.1
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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