Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281 |
Resumo: | Objective: To verify D-dimer values to predict disease severity, degree of lung involvement and mortality in patients with COVID-19. Method: The D-dimer levels of 200 confirmed COVID-19 patients were prospectively measured in the Emergency Department of Razi Hospital of Ahvaz on the admission day, and its relations with the illness severity, computed tomography (CT) score, and mortality were assessed. Results: D-dimer level > 1.04 μg/mL and ≤ 1.12 μg/mL could indicate severe illness and high grade of pulmonary involvement but low risk of death. The mortality rate in the patients with D-dimer level > 1.12 μg/mL (was significantly higher than its rate in those with D-dimer level ≤ 1.12 μg/mL (17.2% x 1.5%; P:0.02). An independent positive correlation was found between D-dimer and Chest CT score as well as the disease severity (OR: 1.84; 95%CI:1.38 - 2.45; P:0.0001). Conclusion: D-dimer level > 1.12 μg/mL on the early stage of COVID-19 infection may independently predict the severe illness, high grade of pulmonary involvement, and high risk of death, indicating its beneficial role in timely management of critical patients. |
id |
PUC_RS-25_6b3efc0980594359f564ae148c29a961 |
---|---|
oai_identifier_str |
oai:ojs.revistaseletronicas.pucrs.br:article/43281 |
network_acronym_str |
PUC_RS-25 |
network_name_str |
Scientia Medica (Porto Alegre. Online) |
repository_id_str |
|
spelling |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19Avaliação do D-dímero como preditor de gravidade, grau de envolvimento pulmonar e mortalidade em pacientes com COVID-19COVID-19D-dimerDisease SeverityPulmonary involvementMortalityCOVID-19D-dímeroGravidade da doençadoença pulmonarMortalidadeObjective: To verify D-dimer values to predict disease severity, degree of lung involvement and mortality in patients with COVID-19. Method: The D-dimer levels of 200 confirmed COVID-19 patients were prospectively measured in the Emergency Department of Razi Hospital of Ahvaz on the admission day, and its relations with the illness severity, computed tomography (CT) score, and mortality were assessed. Results: D-dimer level > 1.04 μg/mL and ≤ 1.12 μg/mL could indicate severe illness and high grade of pulmonary involvement but low risk of death. The mortality rate in the patients with D-dimer level > 1.12 μg/mL (was significantly higher than its rate in those with D-dimer level ≤ 1.12 μg/mL (17.2% x 1.5%; P:0.02). An independent positive correlation was found between D-dimer and Chest CT score as well as the disease severity (OR: 1.84; 95%CI:1.38 - 2.45; P:0.0001). Conclusion: D-dimer level > 1.12 μg/mL on the early stage of COVID-19 infection may independently predict the severe illness, high grade of pulmonary involvement, and high risk of death, indicating its beneficial role in timely management of critical patients.Objetivo: Verificar os valores do D-dímero para predizer a gravidade da doença, o grau de envolvimento pulmonar e a mortalidade em pacientes com COVID-19.Método: Os níveis de dímero D de 200 pacientes confirmados com COVID-19 foram medidos, prospectivamente, no Departamento de Emergência do Hospital Razi de Ahvaz, no dia da admissão, e suas relações com a gravidade da doença, escore de tomografia computadorizada (CT) e mortalidade foram avaliadas. Resultados: Os níveis do D-dímero > 1,04 μg/mL e ≤ 1,12 μg/mL podem indicar doença grave e alto grau de envolvimento pulmonar, mas baixo risco de morte. A taxa de mortalidade nos pacientes com valor de D-dímero > 1,12 μg/mL foi significativamente maior do naqueles com nível de D-dímero ≤ 1,12 μg/mL (17,2% x 1,5%; P:0,02). Foi encontrada uma correlação positiva independente entre o D-dímero e o escore de CT de tórax e a gravidade da doença (OR: 1,84; IC 95%:1,38 - 2,45; P:0,0001). Conclusão: O nível do D-dímero > 1,12 μg/mL no estágio inicial da infecção por COVID-19 pode prever independentemente a doença grave, alto grau de envolvimento pulmonar e alto risco de morte, indicando seu papel benéfico no manejo oportuno de pacientes críticos.Editora da PUCRS - ediPUCRS2022-10-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/4328110.15448/1980-6108.2022.1.43281Scientia Medica; Vol. 32 No. 1 (2022): Single Volume; e43281Scientia Medica; v. 32 n. 1 (2022): Volume Único; e432811980-61081806-556210.15448/1980-6108.2022.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281/27684Copyright (c) 2022 Scientia Medicahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessHosseinzadeh, MofidPouladzadeh, MandanaEftekhar, AminChoghakabodi, Parastoo MoradiSokooti, Alireza2022-12-16T12:09:43Zoai:ojs.revistaseletronicas.pucrs.br:article/43281Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2022-12-16T12:09:43Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 Avaliação do D-dímero como preditor de gravidade, grau de envolvimento pulmonar e mortalidade em pacientes com COVID-19 |
title |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 |
spellingShingle |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 Hosseinzadeh, Mofid COVID-19 D-dimer Disease Severity Pulmonary involvement Mortality COVID-19 D-dímero Gravidade da doença doença pulmonar Mortalidade |
title_short |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 |
title_full |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 |
title_fullStr |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 |
title_full_unstemmed |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 |
title_sort |
Evaluation of D-dimer as a predictor of severity, degree of pulmonary involvement and mortality in patients with COVID-19 |
author |
Hosseinzadeh, Mofid |
author_facet |
Hosseinzadeh, Mofid Pouladzadeh, Mandana Eftekhar, Amin Choghakabodi, Parastoo Moradi Sokooti, Alireza |
author_role |
author |
author2 |
Pouladzadeh, Mandana Eftekhar, Amin Choghakabodi, Parastoo Moradi Sokooti, Alireza |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Hosseinzadeh, Mofid Pouladzadeh, Mandana Eftekhar, Amin Choghakabodi, Parastoo Moradi Sokooti, Alireza |
dc.subject.por.fl_str_mv |
COVID-19 D-dimer Disease Severity Pulmonary involvement Mortality COVID-19 D-dímero Gravidade da doença doença pulmonar Mortalidade |
topic |
COVID-19 D-dimer Disease Severity Pulmonary involvement Mortality COVID-19 D-dímero Gravidade da doença doença pulmonar Mortalidade |
description |
Objective: To verify D-dimer values to predict disease severity, degree of lung involvement and mortality in patients with COVID-19. Method: The D-dimer levels of 200 confirmed COVID-19 patients were prospectively measured in the Emergency Department of Razi Hospital of Ahvaz on the admission day, and its relations with the illness severity, computed tomography (CT) score, and mortality were assessed. Results: D-dimer level > 1.04 μg/mL and ≤ 1.12 μg/mL could indicate severe illness and high grade of pulmonary involvement but low risk of death. The mortality rate in the patients with D-dimer level > 1.12 μg/mL (was significantly higher than its rate in those with D-dimer level ≤ 1.12 μg/mL (17.2% x 1.5%; P:0.02). An independent positive correlation was found between D-dimer and Chest CT score as well as the disease severity (OR: 1.84; 95%CI:1.38 - 2.45; P:0.0001). Conclusion: D-dimer level > 1.12 μg/mL on the early stage of COVID-19 infection may independently predict the severe illness, high grade of pulmonary involvement, and high risk of death, indicating its beneficial role in timely management of critical patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281 10.15448/1980-6108.2022.1.43281 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281 |
identifier_str_mv |
10.15448/1980-6108.2022.1.43281 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/43281/27684 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Scientia Medica http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Scientia Medica http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 32 No. 1 (2022): Single Volume; e43281 Scientia Medica; v. 32 n. 1 (2022): Volume Único; e43281 1980-6108 1806-5562 10.15448/1980-6108.2022.1 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101752562089984 |