Desenvolvimento e avaliação do potencial antioxidante de uma nanoemulsão de uso tópico

• Autor(a) principal: Selbach, Sarah Ledur
• Data de Publicação: 2016
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/7613
• topic: Nanoemulsão; Óleo de Buriti; Chá Verde; Pele; Antioxidante Radicais Livres; CIENCIAS DA SAUDE::FARMACIA

According to INCA (National Institute of Cancer) the cases of skin cancer are increasing exponentially, and it is the world's largest incidence. The increase in ultraviolet index, due to the depletion of the ozone layer, and excessive sun exposure contribute to this fact. The formation of reactive oxygen species (ROS) can be from endogenous and exogenous factors, mainly by exposure to ultraviolet (UV). This are directly linked to the development of several types of cancer, especially skin cancer and photoaging. ROS or free radicals alter the DNA and other biomolecules of the skin, causing genetic mutations that promote and induce cancer incidence. Consequently, the search for new antioxidant substances for topical use is of utmost importance for the prevention of photodamage and skin cancer. This project of master dregree aims to develop a topical nanoemulsion containing these active substances Green tea (Camellia sinensis) and Buriti Oil (Mauritia flexuosa), which have antioxidant properties, and to study their stability in vitro and assess its properties. As a result it is expected to develop a cosmetic raw material that meets a demand of the consumer market, contributing to the prevention of skin cancer and to decrease the signs of cutaneous photoaging.