Resposta aguda máxima em atletas idosos treinados para provas de alto volume : marcadores imunes, endócrinos e redox

• Autor(a) principal: Estrela, André Luiz
• Data de Publicação: 2017
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/8016
• topic: Envelhecimento; Treinamento Físico; Citocinas; Cortisol; Testosterona; Redox; CIENCIAS DA SAUDE::MEDICINA

INTRODUCTION: To verify if there are differences in the hormonal, immunological, redox, chronotropic and physical performance thresholds between two levels of active elderly training induced at two maximum and consecutive sessions in the short term. METHODS: Forty marathon runners were divided based on training load: a higher volume group (n = 19, training ~ 480 min / week) and a smaller group volume (n = 21, training ~ 240 min / week). Inflammatory proteins (PRC, TNF-, IL-6) and plasma oxidative stress biomarkers (protein carbonyls, total thiols), plasma antioxidant enzyme activity (superoxide dismutase, SOD, glutathione peroxidase, GPx) and testosterone and salivary cortisol, Were evaluated at rest (baseline) and in response to the cumulative effect of the two maximal exercise tests, separated by four hours of rest. RESULTS: Most of the parameters were similar between the groups at the beginning of the study, except the lower volume group exhibited higher CRP (+ 60%, p <0.05), higher protein carbonyls (+ 23%, p = 0, 07) and lower SOD activity (-4%, p = 0.06) compared to the higher volume group. TNF- decreased in response to the cumulative effect of similar acute exercise in both groups (ie, baseline vs. one sample collected after the second exercise session), whereas CRP increased differently (+ 60% % Higher group volume, interaction effect p <0.05). IL-6 did not change in any of the groups. Protein carbonyls decreased and total thiols increased similarly in both groups in response to exercise (p<0.05), but SOD activity differentially declined (-14% lower volume, -20% of the higher volume group, Interaction effect p <0.05). GPx did not change in either group. Salivary testosterone decreased in response to exercise was similar in both groups (p <0.05), whereas cortisol did not change. CONCLUSION: Individuals involved in higher volume training have a lower inflammatory response induced by exercise, and a greater decline in the activity of some antioxidant enzymes in post-exercise plasma, compared with individuals engaging in low volume exercise.