In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/78718 |
Resumo: | Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases. |
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In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastasesCiências Tecnológicas, Ciências da engenharia e tecnologiasTechnological sciences, Engineering and technologyThroughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttps://hdl.handle.net/10216/78718eng10.1109/ENBENG.2015.7088832F. Guerra LiberalAdriana TavaresJoão Manuel R. S. Tavaresinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T16:09:48Zoai:repositorio-aberto.up.pt:10216/78718Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:38:25.363941Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
title |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
spellingShingle |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases F. Guerra Liberal Ciências Tecnológicas, Ciências da engenharia e tecnologias Technological sciences, Engineering and technology |
title_short |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
title_full |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
title_fullStr |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
title_full_unstemmed |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
title_sort |
In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases |
author |
F. Guerra Liberal |
author_facet |
F. Guerra Liberal Adriana Tavares João Manuel R. S. Tavares |
author_role |
author |
author2 |
Adriana Tavares João Manuel R. S. Tavares |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
F. Guerra Liberal Adriana Tavares João Manuel R. S. Tavares |
dc.subject.por.fl_str_mv |
Ciências Tecnológicas, Ciências da engenharia e tecnologias Technological sciences, Engineering and technology |
topic |
Ciências Tecnológicas, Ciências da engenharia e tecnologias Technological sciences, Engineering and technology |
description |
Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/78718 |
url |
https://hdl.handle.net/10216/78718 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1109/ENBENG.2015.7088832 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136291543056385 |