Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Detalhes bibliográficos
Autor(a) principal: Marteil, Gaëlle
Data de Publicação: 2018
Outros Autores: Guerrero, Adan, Vieira, André F, de Almeida, Bernardo P, Machado, Pedro, Mendonça, Susana, Mesquita, Marta, Villarreal, Beth, Fonseca, Irina, Francia, Maria E, Dores, Katharina, Martins, Nuno P, Jana, Swadhin C, Tranfield, Erin M, Barbosa-Morais, Nuno L, Paredes, Joana, Pellman, David, Godinho, Susana A, Bettencourt-Dias, Mónica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/857
Resumo: This deposit is composed by the main article plus the supplementary materials of the publication.
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spelling Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregationCancerCentrosomesCentriolesChromosomesThis deposit is composed by the main article plus the supplementary materials of the publication.Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive breast carcinomas. Moreover, we identify another recurrent feature of cancer cells: centriole size deregulation. Further experiments demonstrate that severe centriole over-elongation can promote amplification through both centriole fragmentation and ectopic procentriole formation. Furthermore, we show that overly long centrioles form over-active centrosomes that nucleate more microtubules, a known cause of invasiveness, and perturb chromosome segregation. Our screen establishes centriole amplification and size deregulation as recurrent features of cancer cells and identifies novel causes and consequences of those abnormalities.FCT- Harvard Medical School Program Portugal grant: (HMSP-CT/SAU-ICT/0075/2009); Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/98439/2013, SFRH/BPD/82420/2011, POCI-01-0145-FEDER-016390, PTDC/BIM-ONC/6858/2014); EMBO installation grant; ERC grant: (ERC-2010-StG-261344).Nature Publishing GroupARCAMarteil, GaëlleGuerrero, AdanVieira, André Fde Almeida, Bernardo PMachado, PedroMendonça, SusanaMesquita, MartaVillarreal, BethFonseca, IrinaFrancia, Maria EDores, KatharinaMartins, Nuno PJana, Swadhin CTranfield, Erin MBarbosa-Morais, Nuno LParedes, JoanaPellman, DavidGodinho, Susana ABettencourt-Dias, Mónica2018-04-02T11:42:29Z2018-03-282018-03-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/857engMarteil, G., Guerrero, A., Vieira, A. F., de Almeida, B. P., Machado, P., Mendonça, S., Mesquita, M., Villarreal, B., Fonseca, I., Francia, M. E., Dores, K., Martins, N. P., Jana, S. C., Tranfield, E. M., Barbosa-Morais, N. L., Paredes, J., Pellman, D., Godinho, S. A., Bettencourt-Dias, M. (2018). Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. Nature Communications, 9(1):1258. doi:10.1038/s41467-018-03641-x10.1038/s41467-018-03641-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:16Zoai:arca.igc.gulbenkian.pt:10400.7/857Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:04.322203Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
spellingShingle Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
Marteil, Gaëlle
Cancer
Centrosomes
Centrioles
Chromosomes
title_short Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_full Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_fullStr Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_full_unstemmed Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_sort Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
author Marteil, Gaëlle
author_facet Marteil, Gaëlle
Guerrero, Adan
Vieira, André F
de Almeida, Bernardo P
Machado, Pedro
Mendonça, Susana
Mesquita, Marta
Villarreal, Beth
Fonseca, Irina
Francia, Maria E
Dores, Katharina
Martins, Nuno P
Jana, Swadhin C
Tranfield, Erin M
Barbosa-Morais, Nuno L
Paredes, Joana
Pellman, David
Godinho, Susana A
Bettencourt-Dias, Mónica
author_role author
author2 Guerrero, Adan
Vieira, André F
de Almeida, Bernardo P
Machado, Pedro
Mendonça, Susana
Mesquita, Marta
Villarreal, Beth
Fonseca, Irina
Francia, Maria E
Dores, Katharina
Martins, Nuno P
Jana, Swadhin C
Tranfield, Erin M
Barbosa-Morais, Nuno L
Paredes, Joana
Pellman, David
Godinho, Susana A
Bettencourt-Dias, Mónica
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Marteil, Gaëlle
Guerrero, Adan
Vieira, André F
de Almeida, Bernardo P
Machado, Pedro
Mendonça, Susana
Mesquita, Marta
Villarreal, Beth
Fonseca, Irina
Francia, Maria E
Dores, Katharina
Martins, Nuno P
Jana, Swadhin C
Tranfield, Erin M
Barbosa-Morais, Nuno L
Paredes, Joana
Pellman, David
Godinho, Susana A
Bettencourt-Dias, Mónica
dc.subject.por.fl_str_mv Cancer
Centrosomes
Centrioles
Chromosomes
topic Cancer
Centrosomes
Centrioles
Chromosomes
description This deposit is composed by the main article plus the supplementary materials of the publication.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-02T11:42:29Z
2018-03-28
2018-03-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/857
url http://hdl.handle.net/10400.7/857
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marteil, G., Guerrero, A., Vieira, A. F., de Almeida, B. P., Machado, P., Mendonça, S., Mesquita, M., Villarreal, B., Fonseca, I., Francia, M. E., Dores, K., Martins, N. P., Jana, S. C., Tranfield, E. M., Barbosa-Morais, N. L., Paredes, J., Pellman, D., Godinho, S. A., Bettencourt-Dias, M. (2018). Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. Nature Communications, 9(1):1258. doi:10.1038/s41467-018-03641-x
10.1038/s41467-018-03641-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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