CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/831 |
Resumo: | The deposited article is a post-print version (author's manuscript from PMC and available in PMC 2017 May 9). |
| id |
RCAP_26b09b09655120208c04f3e7f090143a |
|---|---|
| oai_identifier_str |
oai:arca.igc.gulbenkian.pt:10400.7/831 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole BiogenesisPLK4CDKSTILmitosiscentriole duplicationlicensingcentrosomeThe deposited article is a post-print version (author's manuscript from PMC and available in PMC 2017 May 9).This publication hasn't any creative commons license associated.This deposit is composed by the main article and the supplementary materials are present in the publisher's page in the following link: https://www.sciencedirect.com/science/article/pii/S0960982216303001?via%3Dihub#sec4Centrioles are essential for the assembly of both centrosomes and cilia. Centriole biogenesis occurs once and only once per cell cycle and is temporally coordinated with cell-cycle progression, ensuring the formation of the right number of centrioles at the right time. The formation of new daughter centrioles is guided by a pre-existing, mother centriole. The proximity between mother and daughter centrioles was proposed to restrict new centriole formation until they separate beyond a critical distance. Paradoxically, mother and daughter centrioles overcome this distance in early mitosis, at a time when triggers for centriole biogenesis Polo-like kinase 4 (PLK4) and its substrate STIL are abundant. Here we show that in mitosis, the mitotic kinase CDK1-CyclinB binds STIL and prevents formation of the PLK4-STIL complex and STIL phosphorylation by PLK4, thus inhibiting untimely onset of centriole biogenesis. After CDK1-CyclinB inactivation upon mitotic exit, PLK4 can bind and phosphorylate STIL in G1, allowing pro-centriole assembly in the subsequent S phase. Our work shows that complementary mechanisms, such as mother-daughter centriole proximity and CDK1-CyclinB interaction with centriolar components, ensure that centriole biogenesis occurs once and only once per cell cycle, raising parallels to the cell-cycle regulation of DNA replication and centromere formation.ERC grant: (ERC-2010-StG-261344); FCT grants: (FCT Investigator, EXPL/BIM-ONC/0830/2013, PTDC/SAU-BD/105616/2008); EMBO installation grant.ElsevierARCAZitouni, SihemFrancia, Maria E.Leal, FilipeMontenegro Gouveia, SusanaNabais, CatarinaDuarte, PauloGilberto, SamuelBrito, DanielaMoyer, TylerKandels-Lewis, SteffiOhta, MidoriKitagawa, DaijuHolland, Andrew J.Karsenti, EricLorca, ThierryLince-Faria, MarianaBettencourt-Dias, Mónica2018-02-07T14:59:32Z2016-05-092016-05-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/831engSihem Zitouni, Maria E. Francia, Filipe Leal, Susana Montenegro Gouveia, Catarina Nabais, Paulo Duarte, Samuel Gilberto, Daniela Brito, Tyler Moyer, Steffi Kandels-Lewis, Midori Ohta, Daiju Kitagawa, Andrew J. Holland, Eric Karsenti, Thierry Lorca, Mariana Lince-Faria, Mónica Bettencourt-Dias, CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis, Current Biology, Volume 26, Issue 9, 2016, Pages 1127-1137, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2016.03.055. (http://www.sciencedirect.com/science/article/pii/S0960982216303001)10.1016/j.cub.2016.03.055info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:14Zoai:arca.igc.gulbenkian.pt:10400.7/831Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:03.077045Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| title |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| spellingShingle |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis Zitouni, Sihem PLK4 CDK STIL mitosis centriole duplication licensing centrosome |
| title_short |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| title_full |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| title_fullStr |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| title_full_unstemmed |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| title_sort |
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis |
| author |
Zitouni, Sihem |
| author_facet |
Zitouni, Sihem Francia, Maria E. Leal, Filipe Montenegro Gouveia, Susana Nabais, Catarina Duarte, Paulo Gilberto, Samuel Brito, Daniela Moyer, Tyler Kandels-Lewis, Steffi Ohta, Midori Kitagawa, Daiju Holland, Andrew J. Karsenti, Eric Lorca, Thierry Lince-Faria, Mariana Bettencourt-Dias, Mónica |
| author_role |
author |
| author2 |
Francia, Maria E. Leal, Filipe Montenegro Gouveia, Susana Nabais, Catarina Duarte, Paulo Gilberto, Samuel Brito, Daniela Moyer, Tyler Kandels-Lewis, Steffi Ohta, Midori Kitagawa, Daiju Holland, Andrew J. Karsenti, Eric Lorca, Thierry Lince-Faria, Mariana Bettencourt-Dias, Mónica |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Zitouni, Sihem Francia, Maria E. Leal, Filipe Montenegro Gouveia, Susana Nabais, Catarina Duarte, Paulo Gilberto, Samuel Brito, Daniela Moyer, Tyler Kandels-Lewis, Steffi Ohta, Midori Kitagawa, Daiju Holland, Andrew J. Karsenti, Eric Lorca, Thierry Lince-Faria, Mariana Bettencourt-Dias, Mónica |
| dc.subject.por.fl_str_mv |
PLK4 CDK STIL mitosis centriole duplication licensing centrosome |
| topic |
PLK4 CDK STIL mitosis centriole duplication licensing centrosome |
| description |
The deposited article is a post-print version (author's manuscript from PMC and available in PMC 2017 May 9). |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-05-09 2016-05-09T00:00:00Z 2018-02-07T14:59:32Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/831 |
| url |
http://hdl.handle.net/10400.7/831 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Sihem Zitouni, Maria E. Francia, Filipe Leal, Susana Montenegro Gouveia, Catarina Nabais, Paulo Duarte, Samuel Gilberto, Daniela Brito, Tyler Moyer, Steffi Kandels-Lewis, Midori Ohta, Daiju Kitagawa, Andrew J. Holland, Eric Karsenti, Thierry Lorca, Mariana Lince-Faria, Mónica Bettencourt-Dias, CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis, Current Biology, Volume 26, Issue 9, 2016, Pages 1127-1137, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2016.03.055. (http://www.sciencedirect.com/science/article/pii/S0960982216303001) 10.1016/j.cub.2016.03.055 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799130575824486400 |