A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release

Detalhes bibliográficos
Autor(a) principal: Chen, Y.
Data de Publicação: 2018
Outros Autores: Gao, Y., Silva, Lucília Pereira, Pirraco, Rogério P., Ma, M., Yang, L., Reis, R. L., Chen, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/58766
Resumo: Accepted Manuscript
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spelling A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug releaseHydrogelpH-responsiveThermo-responsiveCiências Médicas::Biotecnologia MédicaEngenharia e Tecnologia::Biotecnologia IndustrialScience & TechnologyAccepted ManuscriptThe aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB). The thermo- or pH-sensitive triblock copolymer based on PNIPAM or PAA was synthesized by sequential RAFT polymerization and hydrolysis. By tuning the temperature or pH, the copolymer was able to form diverse nanostructures, including coreâ shell micelles, electronegative or uncharged coreâ shell structures and 3D networks with the hydrophobic forces of PNIPAM or H-bonds between PAA and PNIPAM. Furthermore, the reversible solâ gel transition of the copolymers was modulated by temperature (â ¼37 °C), pH (â ¼5) and concentration (â ¼7 wt%). The drug release potential was evaluated via in vitro injection of copolymer hydrogels into a simulated human body device. The copolymer hydrogels exhibited a sustained drug release behavior and a low instantaneous drug concentration. The MTT studies revealed that there is no noticeable cytotoxicity of NDB or NDA hydrogels against cells. Thus, the tunable drug release efficiency suggests the possibility of PNIPAM- and PAA-based environment responsive hydrogels being applied as drug carrier systems.The authors are very grateful to Shanghai University for the support and help in this subject, and the University of Minho, Portugal for the SEM images used in this study.info:eu-repo/semantics/publishedVersionRoyal Society of ChemistryUniversidade do MinhoChen, Y.Gao, Y.Silva, Lucília PereiraPirraco, Rogério P.Ma, M.Yang, L.Reis, R. L.Chen, J.2018-072018-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/58766engChen Y., Gao Y., da Silva L. P., Ma M., Pirraco R. P., Yang L., Reis R. L., Chen J. A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release, Polymer Chemistry, Vol. 9, Issue 28, pp. 4063-4072, doi:10.1039/c8py00838h, 20181759-996210.1039/c8py00838hhttps://pubs.rsc.org/en/content/articlelanding/2018/py/c8py00838h/unauth#!divAbstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T06:33:44Zoai:repositorium.sdum.uminho.pt:1822/58766Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T06:33:44Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
title A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
spellingShingle A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
Chen, Y.
Hydrogel
pH-responsive
Thermo-responsive
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
title_short A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
title_full A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
title_fullStr A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
title_full_unstemmed A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
title_sort A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
author Chen, Y.
author_facet Chen, Y.
Gao, Y.
Silva, Lucília Pereira
Pirraco, Rogério P.
Ma, M.
Yang, L.
Reis, R. L.
Chen, J.
author_role author
author2 Gao, Y.
Silva, Lucília Pereira
Pirraco, Rogério P.
Ma, M.
Yang, L.
Reis, R. L.
Chen, J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Chen, Y.
Gao, Y.
Silva, Lucília Pereira
Pirraco, Rogério P.
Ma, M.
Yang, L.
Reis, R. L.
Chen, J.
dc.subject.por.fl_str_mv Hydrogel
pH-responsive
Thermo-responsive
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
topic Hydrogel
pH-responsive
Thermo-responsive
Ciências Médicas::Biotecnologia Médica
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
description Accepted Manuscript
publishDate 2018
dc.date.none.fl_str_mv 2018-07
2018-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/58766
url https://hdl.handle.net/1822/58766
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chen Y., Gao Y., da Silva L. P., Ma M., Pirraco R. P., Yang L., Reis R. L., Chen J. A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release, Polymer Chemistry, Vol. 9, Issue 28, pp. 4063-4072, doi:10.1039/c8py00838h, 2018
1759-9962
10.1039/c8py00838h
https://pubs.rsc.org/en/content/articlelanding/2018/py/c8py00838h/unauth#!divAbstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817545014995058688

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