Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)

Detalhes bibliográficos
Autor(a) principal: Oliveira,Adriano Marim de
Data de Publicação: 2009
Outros Autores: Oliveira,Pedro Carlos de, Santos,Amilton Martins dos, Zanin,Maria Helena Ambrosio, Ré,Maria Inês
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Physics
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332009000200015
Resumo: A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system.
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spelling Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)thermo-responsive particlesdexametasone acetatedrug releaseblock copolymerRAFTA new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system.Sociedade Brasileira de Física2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332009000200015Brazilian Journal of Physics v.39 n.1a 2009reponame:Brazilian Journal of Physicsinstname:Sociedade Brasileira de Física (SBF)instacron:SBF10.1590/S0103-97332009000200015info:eu-repo/semantics/openAccessOliveira,Adriano Marim deOliveira,Pedro Carlos deSantos,Amilton Martins dosZanin,Maria Helena AmbrosioRé,Maria Inêseng2009-07-03T00:00:00Zoai:scielo:S0103-97332009000200015Revistahttp://www.sbfisica.org.br/v1/home/index.php/pt/ONGhttps://old.scielo.br/oai/scielo-oai.phpsbfisica@sbfisica.org.br||sbfisica@sbfisica.org.br1678-44480103-9733opendoar:2009-07-03T00:00Brazilian Journal of Physics - Sociedade Brasileira de Física (SBF)false
dc.title.none.fl_str_mv Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
title Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
spellingShingle Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
Oliveira,Adriano Marim de
thermo-responsive particles
dexametasone acetate
drug release
block copolymer
RAFT
title_short Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
title_full Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
title_fullStr Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
title_full_unstemmed Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
title_sort Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)
author Oliveira,Adriano Marim de
author_facet Oliveira,Adriano Marim de
Oliveira,Pedro Carlos de
Santos,Amilton Martins dos
Zanin,Maria Helena Ambrosio
Ré,Maria Inês
author_role author
author2 Oliveira,Pedro Carlos de
Santos,Amilton Martins dos
Zanin,Maria Helena Ambrosio
Ré,Maria Inês
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Adriano Marim de
Oliveira,Pedro Carlos de
Santos,Amilton Martins dos
Zanin,Maria Helena Ambrosio
Ré,Maria Inês
dc.subject.por.fl_str_mv thermo-responsive particles
dexametasone acetate
drug release
block copolymer
RAFT
topic thermo-responsive particles
dexametasone acetate
drug release
block copolymer
RAFT
description A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system.
publishDate 2009
dc.date.none.fl_str_mv 2009-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332009000200015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332009000200015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-97332009000200015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Física
publisher.none.fl_str_mv Sociedade Brasileira de Física
dc.source.none.fl_str_mv Brazilian Journal of Physics v.39 n.1a 2009
reponame:Brazilian Journal of Physics
instname:Sociedade Brasileira de Física (SBF)
instacron:SBF
instname_str Sociedade Brasileira de Física (SBF)
instacron_str SBF
institution SBF
reponame_str Brazilian Journal of Physics
collection Brazilian Journal of Physics
repository.name.fl_str_mv Brazilian Journal of Physics - Sociedade Brasileira de Física (SBF)
repository.mail.fl_str_mv sbfisica@sbfisica.org.br||sbfisica@sbfisica.org.br
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