Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells

Detalhes bibliográficos
Autor(a) principal: Moreira, André
Data de Publicação: 2017
Outros Autores: Dias, Diana Rodrigues, Costa, Elisabete C., Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: spa
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4698
Resumo: Drug combinatorial therapy has been gaining the scientific community attention as a suitable approach to increase treatments efficacy and promote cancer eradication. In this study, a new pH- and thermo- responsive carrier was developed by combining doxorubicin-loaded gold-core silica shell nanorods with salicylic acid loaded poly (lactic-co-glycolic acid) based microparticles (NIMPS). The obtained results showed that the drugs and nanorods release could be triggered by the near-infrared (NIR) laser irradiation or by the exposition to an acidic environment. The in vitro 2D cell studies showed that the NIMPS are biocompatible and easily uptaken by HeLa cells. In addition, 3D cell culture models revealed that the NIMPS administration, combined with the NIR laser irradiation, was capable of reducing the size of the HeLa spheroids up to 48%. Overall, the attained data support the application of the nano-in-micro spheres as a dual stimuli responsive drug carrier system for the local administration of combined therapies to cervical cancer cells.
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spelling Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cellsPLGA microparticlespH-ResponsiveThermo-responsiveDrug combinationDrug combinatorial therapy has been gaining the scientific community attention as a suitable approach to increase treatments efficacy and promote cancer eradication. In this study, a new pH- and thermo- responsive carrier was developed by combining doxorubicin-loaded gold-core silica shell nanorods with salicylic acid loaded poly (lactic-co-glycolic acid) based microparticles (NIMPS). The obtained results showed that the drugs and nanorods release could be triggered by the near-infrared (NIR) laser irradiation or by the exposition to an acidic environment. The in vitro 2D cell studies showed that the NIMPS are biocompatible and easily uptaken by HeLa cells. In addition, 3D cell culture models revealed that the NIMPS administration, combined with the NIR laser irradiation, was capable of reducing the size of the HeLa spheroids up to 48%. Overall, the attained data support the application of the nano-in-micro spheres as a dual stimuli responsive drug carrier system for the local administration of combined therapies to cervical cancer cells.ElsevieruBibliorumMoreira, AndréDias, Diana RodriguesCosta, Elisabete C.Correia, Ilídio Joaquim Sobreira2018-03-22T09:07:18Z2017-03-252017-03-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4698spaMoreira, A. F., Dias, D. R., Costa, E. C., e Correia, I.J. (2017). “Thermo-and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells.” European Journal of Pharmaceutical Sciences, Vol.104, pp.42-5110.1016/j.ejps.2017.03.033metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T12:15:14Zoai:ubibliorum.ubi.pt:10400.6/4698Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T12:15:14Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
title Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
spellingShingle Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
Moreira, André
PLGA microparticles
pH-Responsive
Thermo-responsive
Drug combination
title_short Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
title_full Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
title_fullStr Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
title_full_unstemmed Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
title_sort Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells
author Moreira, André
author_facet Moreira, André
Dias, Diana Rodrigues
Costa, Elisabete C.
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Dias, Diana Rodrigues
Costa, Elisabete C.
Correia, Ilídio Joaquim Sobreira
author2_role author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Moreira, André
Dias, Diana Rodrigues
Costa, Elisabete C.
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv PLGA microparticles
pH-Responsive
Thermo-responsive
Drug combination
topic PLGA microparticles
pH-Responsive
Thermo-responsive
Drug combination
description Drug combinatorial therapy has been gaining the scientific community attention as a suitable approach to increase treatments efficacy and promote cancer eradication. In this study, a new pH- and thermo- responsive carrier was developed by combining doxorubicin-loaded gold-core silica shell nanorods with salicylic acid loaded poly (lactic-co-glycolic acid) based microparticles (NIMPS). The obtained results showed that the drugs and nanorods release could be triggered by the near-infrared (NIR) laser irradiation or by the exposition to an acidic environment. The in vitro 2D cell studies showed that the NIMPS are biocompatible and easily uptaken by HeLa cells. In addition, 3D cell culture models revealed that the NIMPS administration, combined with the NIR laser irradiation, was capable of reducing the size of the HeLa spheroids up to 48%. Overall, the attained data support the application of the nano-in-micro spheres as a dual stimuli responsive drug carrier system for the local administration of combined therapies to cervical cancer cells.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-25
2017-03-25T00:00:00Z
2018-03-22T09:07:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4698
url http://hdl.handle.net/10400.6/4698
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv Moreira, A. F., Dias, D. R., Costa, E. C., e Correia, I.J. (2017). “Thermo-and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells.” European Journal of Pharmaceutical Sciences, Vol.104, pp.42-51
10.1016/j.ejps.2017.03.033
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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