Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/130455 |
Resumo: | The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatusActinomycetesAntibiofilmAntifoulingBiofoulingBioprospectionDrug discoveryHybrid isoprenoidsMarine natural productsMeroterpenoidsNapyradiomycinsThe undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/130455engISSN 1660-3397https://doi.org/10.3390/md18010063Pereira, F.Almeida, J.R.Paulino, M.Grilo, I.R.Macedo, H.Cunha, I.Sobral, R.G.Vasconcelos, V.Gaudêncio, S.P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:52:28Zoai:repositorio-aberto.up.pt:10216/130455Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:49:24.792804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
title |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
spellingShingle |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus Pereira, F. Actinomycetes Antibiofilm Antifouling Biofouling Bioprospection Drug discovery Hybrid isoprenoids Marine natural products Meroterpenoids Napyradiomycins |
title_short |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
title_full |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
title_fullStr |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
title_full_unstemmed |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
title_sort |
Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus |
author |
Pereira, F. |
author_facet |
Pereira, F. Almeida, J.R. Paulino, M. Grilo, I.R. Macedo, H. Cunha, I. Sobral, R.G. Vasconcelos, V. Gaudêncio, S.P. |
author_role |
author |
author2 |
Almeida, J.R. Paulino, M. Grilo, I.R. Macedo, H. Cunha, I. Sobral, R.G. Vasconcelos, V. Gaudêncio, S.P. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, F. Almeida, J.R. Paulino, M. Grilo, I.R. Macedo, H. Cunha, I. Sobral, R.G. Vasconcelos, V. Gaudêncio, S.P. |
dc.subject.por.fl_str_mv |
Actinomycetes Antibiofilm Antifouling Biofouling Bioprospection Drug discovery Hybrid isoprenoids Marine natural products Meroterpenoids Napyradiomycins |
topic |
Actinomycetes Antibiofilm Antifouling Biofouling Bioprospection Drug discovery Hybrid isoprenoids Marine natural products Meroterpenoids Napyradiomycins |
description |
The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/130455 |
url |
https://hdl.handle.net/10216/130455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ISSN 1660-3397 https://doi.org/10.3390/md18010063 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135813647204352 |