Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus

Detalhes bibliográficos
Autor(a) principal: Pereira, Florbela
Data de Publicação: 2020
Outros Autores: Almeida, Joana R., Paulino, Marisa, Grilo, Inês R., Macedo, Helena, Cunha, Isabel, Sobral, Rita G., Vasconcelos, Vitor, Gaudêncio, Susana P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/109141
Resumo: UID/Multi/04378/2019 UID/Multi/04423/2019 FP7/2007–2013 DFRH/WIIA/102/2011 SFRH/BI/52130/ 2013 IF/00700/2014 SFRH/BPD/110020/2015 PTDC/BIA-MIC/31645/2017 PTDC/BTA-GES/ 32359/2017 PTDC/BTA-BTA/31422/2017 POCI-01-0145-FEDER-031422
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spelling Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatusActinomycetesAntibiofilmAntifoulingBiofoulingBioprospectionDrug discoveryHybrid isoprenoidsMarine natural productsMeroterpenoidsNapyradiomycinsDrug DiscoverySDG 14 - Life Below WaterUID/Multi/04378/2019 UID/Multi/04423/2019 FP7/2007–2013 DFRH/WIIA/102/2011 SFRH/BI/52130/ 2013 IF/00700/2014 SFRH/BPD/110020/2015 PTDC/BIA-MIC/31645/2017 PTDC/BTA-GES/ 32359/2017 PTDC/BTA-BTA/31422/2017 POCI-01-0145-FEDER-031422The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products.LAQV@REQUIMTEDQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNPereira, FlorbelaAlmeida, Joana R.Paulino, MarisaGrilo, Inês R.Macedo, HelenaCunha, IsabelSobral, Rita G.Vasconcelos, VitorGaudêncio, Susana P.2020-12-22T05:15:19Z2020-01-182020-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/109141eng1660-3397PURE: 17107846https://doi.org/10.3390/md18010063info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:53:39Zoai:run.unl.pt:10362/109141Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:41:25.501643Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
spellingShingle Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
Pereira, Florbela
Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
Drug Discovery
SDG 14 - Life Below Water
title_short Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_full Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_fullStr Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_full_unstemmed Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
title_sort Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
author Pereira, Florbela
author_facet Pereira, Florbela
Almeida, Joana R.
Paulino, Marisa
Grilo, Inês R.
Macedo, Helena
Cunha, Isabel
Sobral, Rita G.
Vasconcelos, Vitor
Gaudêncio, Susana P.
author_role author
author2 Almeida, Joana R.
Paulino, Marisa
Grilo, Inês R.
Macedo, Helena
Cunha, Isabel
Sobral, Rita G.
Vasconcelos, Vitor
Gaudêncio, Susana P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Pereira, Florbela
Almeida, Joana R.
Paulino, Marisa
Grilo, Inês R.
Macedo, Helena
Cunha, Isabel
Sobral, Rita G.
Vasconcelos, Vitor
Gaudêncio, Susana P.
dc.subject.por.fl_str_mv Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
Drug Discovery
SDG 14 - Life Below Water
topic Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
Drug Discovery
SDG 14 - Life Below Water
description UID/Multi/04378/2019 UID/Multi/04423/2019 FP7/2007–2013 DFRH/WIIA/102/2011 SFRH/BI/52130/ 2013 IF/00700/2014 SFRH/BPD/110020/2015 PTDC/BIA-MIC/31645/2017 PTDC/BTA-GES/ 32359/2017 PTDC/BTA-BTA/31422/2017 POCI-01-0145-FEDER-031422
publishDate 2020
dc.date.none.fl_str_mv 2020-12-22T05:15:19Z
2020-01-18
2020-01-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/109141
url http://hdl.handle.net/10362/109141
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-3397
PURE: 17107846
https://doi.org/10.3390/md18010063
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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