Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®

Detalhes bibliográficos
Autor(a) principal: Hammami, Imen
Data de Publicação: 2024
Outros Autores: Graça, Manuel Pedro Fernandes, Gavinho, Sílvia Rodrigues, Jakka, Suresh Kumar, Borges, João Paulo, Silva, Jorge Carvalho, Costa, Luís Cadillon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/172491
Resumo: Funding Information: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3N. S.K. Jakka acknowledges the FCT—Fundaçao para a Ciência e a Tecnologia, Portugal, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2024 by the authors.
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spelling Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®bioglassbiomaterialelectrical propertiesimplant coatingsosseointegrationBiotechnologyBioengineeringBiomaterialsBiochemistryBiomedical EngineeringMolecular MedicineFunding Information: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3N. S.K. Jakka acknowledges the FCT—Fundaçao para a Ciência e a Tecnologia, Portugal, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2024 by the authors.In recent decades, the requirements for implantable medical devices have increased, but the risks of implant rejection still exist. These issues are primarily associated with poor osseointegration, leading to biofilm formation on the implant surface. This study focuses on addressing these issues by developing a biomaterial for implant coatings. 45S5 bioglass® has been widely used in tissue engineering due to its ability to form a hydroxyapatite layer, ensuring a strong bond between the hard tissue and the bioglass. In this context, 45S5 bioglasses®, modified by the incorporation of different amounts of copper oxide, from 0 to 8 mol%, were synthesized by the melt–quenching technique. The incorporation of Cu ions did not show a significant change in the glass structure. Since the bioglass exhibited the capacity for being polarized, thereby promoting the osseointegration effectiveness, the electrical properties of the prepared samples were studied using the impedance spectroscopy method, in the frequency range of 102–106 Hz and temperature range of 200–400 K. The effects of CuO on charge transport mobility were investigated. Additionally, the bioactivity of the modified bioglasses was evaluated through immersion tests in simulated body fluid. The results revealed the initiation of a Ca–P-rich layer formation on the surface within 24 h, indicating the potential of the bioglasses to enhance the bone regeneration process.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaRUNHammami, ImenGraça, Manuel Pedro FernandesGavinho, Sílvia RodriguesJakka, Suresh KumarBorges, João PauloSilva, Jorge CarvalhoCosta, Luís Cadillon2024-09-26T22:26:03Z2024-04-022024-04-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/172491eng2313-7673PURE: 99745550https://doi.org/10.3390/biomimetics9040213info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-21T01:37:29Zoai:run.unl.pt:10362/172491Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-21T01:37:29Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
title Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
spellingShingle Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
Hammami, Imen
bioglass
biomaterial
electrical properties
implant coatings
osseointegration
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
title_short Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
title_full Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
title_fullStr Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
title_full_unstemmed Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
title_sort Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
author Hammami, Imen
author_facet Hammami, Imen
Graça, Manuel Pedro Fernandes
Gavinho, Sílvia Rodrigues
Jakka, Suresh Kumar
Borges, João Paulo
Silva, Jorge Carvalho
Costa, Luís Cadillon
author_role author
author2 Graça, Manuel Pedro Fernandes
Gavinho, Sílvia Rodrigues
Jakka, Suresh Kumar
Borges, João Paulo
Silva, Jorge Carvalho
Costa, Luís Cadillon
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Hammami, Imen
Graça, Manuel Pedro Fernandes
Gavinho, Sílvia Rodrigues
Jakka, Suresh Kumar
Borges, João Paulo
Silva, Jorge Carvalho
Costa, Luís Cadillon
dc.subject.por.fl_str_mv bioglass
biomaterial
electrical properties
implant coatings
osseointegration
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
topic bioglass
biomaterial
electrical properties
implant coatings
osseointegration
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
description Funding Information: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3N. S.K. Jakka acknowledges the FCT—Fundaçao para a Ciência e a Tecnologia, Portugal, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-09-26T22:26:03Z
2024-04-02
2024-04-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/172491
url http://hdl.handle.net/10362/172491
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2313-7673
PURE: 99745550
https://doi.org/10.3390/biomimetics9040213
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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