Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/39882 |
Resumo: | Biofilm-related implant infections pose a substantial threat to patients, leading to inflammation in the surrounding tissue, and often resulting in implant loss and the necessity for additional surgeries. Overcoming this implantology challenge is crucial to ensure the success and durability of implants. This study shows the development of antibacterial materials for implant coatings by incorporating copper into 45S5 Bioglass®. By combining the regenerative properties of Bioglass® with the antimicrobial effects of copper, this material has the potential to prevent infections, enhance osseointegration and improve the long-term success of implants. Bioglasses modified with various concentrations of CuO (from 0 to 8 mol%) were prepared with the melt-quenching technique. Structural analysis using Raman and FTIR spectroscopies did not reveal significant alterations in the bioglasses structure with the addition of Cu. The antibacterial activity of the samples was assessed against Gram-positive and Gram-negative bacteria, and the results demonstrated significant inhibition of bacterial growth for the bioglass with 0.5 mol% of CuO. Cell viability studies indicated that the samples modified with up to 4 mol% of CuO maintained good cytocompatibility with the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the bioactivity assessment demonstrated the formation of a calcium phosphate (CaP)-rich layer on the surfaces of all bioglasses within 24 h. Our findings show that the inclusion of copper in the bioglass offers a significant enhancement in its potential as a coating material for implants, resulting in notable advancements in both antibacterial efficacy and osteointegration properties. |
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Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants CoatingAntibacterial activityBioactivityBioglassCopperImplant coatingOsseointegrationBiofilm-related implant infections pose a substantial threat to patients, leading to inflammation in the surrounding tissue, and often resulting in implant loss and the necessity for additional surgeries. Overcoming this implantology challenge is crucial to ensure the success and durability of implants. This study shows the development of antibacterial materials for implant coatings by incorporating copper into 45S5 Bioglass®. By combining the regenerative properties of Bioglass® with the antimicrobial effects of copper, this material has the potential to prevent infections, enhance osseointegration and improve the long-term success of implants. Bioglasses modified with various concentrations of CuO (from 0 to 8 mol%) were prepared with the melt-quenching technique. Structural analysis using Raman and FTIR spectroscopies did not reveal significant alterations in the bioglasses structure with the addition of Cu. The antibacterial activity of the samples was assessed against Gram-positive and Gram-negative bacteria, and the results demonstrated significant inhibition of bacterial growth for the bioglass with 0.5 mol% of CuO. Cell viability studies indicated that the samples modified with up to 4 mol% of CuO maintained good cytocompatibility with the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the bioactivity assessment demonstrated the formation of a calcium phosphate (CaP)-rich layer on the surfaces of all bioglasses within 24 h. Our findings show that the inclusion of copper in the bioglass offers a significant enhancement in its potential as a coating material for implants, resulting in notable advancements in both antibacterial efficacy and osteointegration properties.MDPI2023-12-21T12:43:44Z2023-07-13T00:00:00Z2023-07-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/39882eng2079-498310.3390/jfb14070369Hammami, ImenGavinho, Sílvia RodriguesJakka, Suresh KumarValente, Manuel AlmeidaGraça, Manuel Pedro FernandesPádua, Ana SofiaSilva, Jorge CarvalhoSá-Nogueira, IsabelBorges, João Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:17:36Zoai:ria.ua.pt:10773/39882Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:09:49.830447Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
title |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
spellingShingle |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating Hammami, Imen Antibacterial activity Bioactivity Bioglass Copper Implant coating Osseointegration |
title_short |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
title_full |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
title_fullStr |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
title_full_unstemmed |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
title_sort |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
author |
Hammami, Imen |
author_facet |
Hammami, Imen Gavinho, Sílvia Rodrigues Jakka, Suresh Kumar Valente, Manuel Almeida Graça, Manuel Pedro Fernandes Pádua, Ana Sofia Silva, Jorge Carvalho Sá-Nogueira, Isabel Borges, João Paulo |
author_role |
author |
author2 |
Gavinho, Sílvia Rodrigues Jakka, Suresh Kumar Valente, Manuel Almeida Graça, Manuel Pedro Fernandes Pádua, Ana Sofia Silva, Jorge Carvalho Sá-Nogueira, Isabel Borges, João Paulo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hammami, Imen Gavinho, Sílvia Rodrigues Jakka, Suresh Kumar Valente, Manuel Almeida Graça, Manuel Pedro Fernandes Pádua, Ana Sofia Silva, Jorge Carvalho Sá-Nogueira, Isabel Borges, João Paulo |
dc.subject.por.fl_str_mv |
Antibacterial activity Bioactivity Bioglass Copper Implant coating Osseointegration |
topic |
Antibacterial activity Bioactivity Bioglass Copper Implant coating Osseointegration |
description |
Biofilm-related implant infections pose a substantial threat to patients, leading to inflammation in the surrounding tissue, and often resulting in implant loss and the necessity for additional surgeries. Overcoming this implantology challenge is crucial to ensure the success and durability of implants. This study shows the development of antibacterial materials for implant coatings by incorporating copper into 45S5 Bioglass®. By combining the regenerative properties of Bioglass® with the antimicrobial effects of copper, this material has the potential to prevent infections, enhance osseointegration and improve the long-term success of implants. Bioglasses modified with various concentrations of CuO (from 0 to 8 mol%) were prepared with the melt-quenching technique. Structural analysis using Raman and FTIR spectroscopies did not reveal significant alterations in the bioglasses structure with the addition of Cu. The antibacterial activity of the samples was assessed against Gram-positive and Gram-negative bacteria, and the results demonstrated significant inhibition of bacterial growth for the bioglass with 0.5 mol% of CuO. Cell viability studies indicated that the samples modified with up to 4 mol% of CuO maintained good cytocompatibility with the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the bioactivity assessment demonstrated the formation of a calcium phosphate (CaP)-rich layer on the surfaces of all bioglasses within 24 h. Our findings show that the inclusion of copper in the bioglass offers a significant enhancement in its potential as a coating material for implants, resulting in notable advancements in both antibacterial efficacy and osteointegration properties. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-21T12:43:44Z 2023-07-13T00:00:00Z 2023-07-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/39882 |
url |
http://hdl.handle.net/10773/39882 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2079-4983 10.3390/jfb14070369 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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