Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/159675 |
Resumo: | This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology—for the UI/DB/151287/2021). S.K.J. acknowledges FCT—Fundaçao para a Ciência e Tecnologia, Portugal, I.P.—in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors. |
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Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coatingantibacterial activitybioactivityBioglasscopperimplant coatingosseointegrationBiomaterialsBiomedical EngineeringThis research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology—for the UI/DB/151287/2021). S.K.J. acknowledges FCT—Fundaçao para a Ciência e Tecnologia, Portugal, I.P.—in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors.Biofilm-related implant infections pose a substantial threat to patients, leading to inflammation in the surrounding tissue, and often resulting in implant loss and the necessity for additional surgeries. Overcoming this implantology challenge is crucial to ensure the success and durability of implants. This study shows the development of antibacterial materials for implant coatings by incorporating copper into 45S5 Bioglass®. By combining the regenerative properties of Bioglass® with the antimicrobial effects of copper, this material has the potential to prevent infections, enhance osseointegration and improve the long-term success of implants. Bioglasses modified with various concentrations of CuO (from 0 to 8 mol%) were prepared with the melt-quenching technique. Structural analysis using Raman and FTIR spectroscopies did not reveal significant alterations in the bioglasses structure with the addition of Cu. The antibacterial activity of the samples was assessed against Gram-positive and Gram-negative bacteria, and the results demonstrated significant inhibition of bacterial growth for the bioglass with 0.5 mol% of CuO. Cell viability studies indicated that the samples modified with up to 4 mol% of CuO maintained good cytocompatibility with the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the bioactivity assessment demonstrated the formation of a calcium phosphate (CaP)-rich layer on the surfaces of all bioglasses within 24 h. Our findings show that the inclusion of copper in the bioglass offers a significant enhancement in its potential as a coating material for implants, resulting in notable advancements in both antibacterial efficacy and osteointegration properties.DF – Departamento de FísicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaDCM - Departamento de Ciência dos MateriaisRUNHammami, ImenGavinho, Sílvia RodriguesJakka, Suresh KumarValente, Manuel AlmeidaGraça, Manuel Pedro FernandesPádua, Ana SofiaSilva, Jorge CarvalhoSá-Nogueira, IsabelBorges, João Paulo2023-11-07T22:09:10Z2023-07-132023-07-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/159675eng2079-4983PURE: 75588461https://doi.org/10.3390/jfb14070369info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:06Zoai:run.unl.pt:10362/159675Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:38.936509Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| title |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| spellingShingle |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating Hammami, Imen antibacterial activity bioactivity Bioglass copper implant coating osseointegration Biomaterials Biomedical Engineering |
| title_short |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| title_full |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| title_fullStr |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| title_full_unstemmed |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| title_sort |
Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating |
| author |
Hammami, Imen |
| author_facet |
Hammami, Imen Gavinho, Sílvia Rodrigues Jakka, Suresh Kumar Valente, Manuel Almeida Graça, Manuel Pedro Fernandes Pádua, Ana Sofia Silva, Jorge Carvalho Sá-Nogueira, Isabel Borges, João Paulo |
| author_role |
author |
| author2 |
Gavinho, Sílvia Rodrigues Jakka, Suresh Kumar Valente, Manuel Almeida Graça, Manuel Pedro Fernandes Pádua, Ana Sofia Silva, Jorge Carvalho Sá-Nogueira, Isabel Borges, João Paulo |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DF – Departamento de Física CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida DCM - Departamento de Ciência dos Materiais RUN |
| dc.contributor.author.fl_str_mv |
Hammami, Imen Gavinho, Sílvia Rodrigues Jakka, Suresh Kumar Valente, Manuel Almeida Graça, Manuel Pedro Fernandes Pádua, Ana Sofia Silva, Jorge Carvalho Sá-Nogueira, Isabel Borges, João Paulo |
| dc.subject.por.fl_str_mv |
antibacterial activity bioactivity Bioglass copper implant coating osseointegration Biomaterials Biomedical Engineering |
| topic |
antibacterial activity bioactivity Bioglass copper implant coating osseointegration Biomaterials Biomedical Engineering |
| description |
This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology—for the UI/DB/151287/2021). S.K.J. acknowledges FCT—Fundaçao para a Ciência e Tecnologia, Portugal, I.P.—in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-07T22:09:10Z 2023-07-13 2023-07-13T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/159675 |
| url |
http://hdl.handle.net/10362/159675 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2079-4983 PURE: 75588461 https://doi.org/10.3390/jfb14070369 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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17 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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