The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/48294 |
Resumo: | © 2020 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort studyAgomelatineLiver acceptabilityObservationalSafety-medical practiceSkin events© 2020 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Objective: The present observational cohort study documented the safety of agomelatine in current medical practice in out-patients suffering from major depressive disorder. Method: The 6-month evolution of agomelatine-treated patients was assessed with a focus on safety (emergent adverse events, liver acceptability), severity of depression using the Clinical Global Impression Severity (CGI-S) score, and functioning measured by the Sheehan Disability Scale (SDS). Results: A total of 8453 depressed patients from 761 centres in 6 countries were analysed (female: 67.7%; mean age: 49.1 ± 14.8 years). Adverse events reported were in accordance with the known safety profile of agomelatine. Cutaneous events were reported in 1.7% of the patients and increased hepatic transaminases values were reported in 0.9 % of the patients. The incidence of events related to suicide/self-injury was 1.0%. Two completed suicides, not related to the study drug, were reported. CGI-S total scores and SDS sub-scores improved and numbers of days lost or underproductive decreased over the treatment period. Conclusions: In standard medical practice, agomelatine treatment was associated with a low incidence of side effects. No unexpected events were reported. A decrease in the severity of the depressive episode and improved functioning were observed.John Wiley & Sons, Inc.Repositório da Universidade de LisboaGorwood, PhilipBenichou, JacquesMoore, NicholasÁlvarez Martínez, EnricMertens, JoostAguglia, EugenioFigueira, Maria LuísaFalkai, PeterOlivier, ValérieWattez, MarinePicarel‐Blanchot, Françoisede Bodinat, Christian2021-06-01T13:56:05Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48294engHum Psychopharmacol. 2021 Jan;36(1):1-110885-622210.1002/hup.27591099-1077info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:35Zoai:repositorio.ul.pt:10451/48294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:11.845073Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| title |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| spellingShingle |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study Gorwood, Philip Agomelatine Liver acceptability Observational Safety-medical practice Skin events |
| title_short |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| title_full |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| title_fullStr |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| title_full_unstemmed |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| title_sort |
The safety of agomelatine in standard medical practice in depressed patients : a 26‐week international multicentre cohort study |
| author |
Gorwood, Philip |
| author_facet |
Gorwood, Philip Benichou, Jacques Moore, Nicholas Álvarez Martínez, Enric Mertens, Joost Aguglia, Eugenio Figueira, Maria Luísa Falkai, Peter Olivier, Valérie Wattez, Marine Picarel‐Blanchot, Françoise de Bodinat, Christian |
| author_role |
author |
| author2 |
Benichou, Jacques Moore, Nicholas Álvarez Martínez, Enric Mertens, Joost Aguglia, Eugenio Figueira, Maria Luísa Falkai, Peter Olivier, Valérie Wattez, Marine Picarel‐Blanchot, Françoise de Bodinat, Christian |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Gorwood, Philip Benichou, Jacques Moore, Nicholas Álvarez Martínez, Enric Mertens, Joost Aguglia, Eugenio Figueira, Maria Luísa Falkai, Peter Olivier, Valérie Wattez, Marine Picarel‐Blanchot, Françoise de Bodinat, Christian |
| dc.subject.por.fl_str_mv |
Agomelatine Liver acceptability Observational Safety-medical practice Skin events |
| topic |
Agomelatine Liver acceptability Observational Safety-medical practice Skin events |
| description |
© 2020 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-06-01T13:56:05Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48294 |
| url |
http://hdl.handle.net/10451/48294 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Hum Psychopharmacol. 2021 Jan;36(1):1-11 0885-6222 10.1002/hup.2759 1099-1077 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
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John Wiley & Sons, Inc. |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134548873707520 |