In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes

Detalhes bibliográficos
Autor(a) principal: Choroba, Katarzyna
Data de Publicação: 2023
Outros Autores: Filipe, Beatriz, Świtlicka, Anna, Penkala, Mateusz, Machura, Barbara, Bieńko, Alina, Cordeiro, Sandra, Baptista, Pedro V., Fernandes, Alexandra R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/160196
Resumo: funds granted under the Research Excellence Initiative of the University of Silesia in Katowice. The authors thank Dr inż. Mariola Siwy for measurements of elemental analysis. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.
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spelling In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) ComplexesMolecular MedicineDrug DiscoverySDG 3 - Good Health and Well-beingfunds granted under the Research Excellence Initiative of the University of Silesia in Katowice. The authors thank Dr inż. Mariola Siwy for measurements of elemental analysis. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.The work is focused on anticancer properties of dipicolinate (dipic)-based vanadium(IV) complexes [VO(dipic)(N∩N)] bearing different diimines (2-(1H-imidazol-2-yl)pyridine, 2-(2-pyridyl)benzimidazole, 1,10-phenanthroline-5,6-dione, 1,10-phenanthroline, and 2,2′-bipyridine), as well as differently 4,7-substituted 1,10-phenanthrolines. The antiproliferative effect of V(IV) systems was analyzed in different tumors (A2780, HCT116, and HCT116-DoxR) and normal (primary human dermal fibroblasts) cell lines, revealing a high cytotoxic effect of [VO(dipic)(N∩N)] with 4,7-dimethoxy-phen (5), 4,7-diphenyl-phen (6), and 1,10-phenanthroline (8) against HCT116-DoxR cells. The cytotoxicity differences between these complexes can be correlated with their different internalization by HCT116-DoxR cells. Worthy of note, these three complexes were found to (i) induce cell death through apoptosis and autophagy pathways, namely, through ROS production; (ii) not to be cytostatic; (iii) to interact with the BSA protein; (iv) do not promote tumor cell migration or a pro-angiogenic capability; (v) show a slight in vivo anti-angiogenic capability, and (vi) do not show in vivo toxicity in a chicken embryo.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNChoroba, KatarzynaFilipe, BeatrizŚwitlicka, AnnaPenkala, MateuszMachura, BarbaraBieńko, AlinaCordeiro, SandraBaptista, Pedro V.Fernandes, Alexandra R.2023-11-20T22:10:52Z2023-07-132023-07-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/160196eng0022-2623PURE: 75590433https://doi.org/10.1021/acs.jmedchem.3c00255info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:45Zoai:run.unl.pt:10362/160196Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:54.106638Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
title In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
spellingShingle In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
Choroba, Katarzyna
Molecular Medicine
Drug Discovery
SDG 3 - Good Health and Well-being
title_short In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
title_full In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
title_fullStr In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
title_full_unstemmed In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
title_sort In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes
author Choroba, Katarzyna
author_facet Choroba, Katarzyna
Filipe, Beatriz
Świtlicka, Anna
Penkala, Mateusz
Machura, Barbara
Bieńko, Alina
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
author_role author
author2 Filipe, Beatriz
Świtlicka, Anna
Penkala, Mateusz
Machura, Barbara
Bieńko, Alina
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Choroba, Katarzyna
Filipe, Beatriz
Świtlicka, Anna
Penkala, Mateusz
Machura, Barbara
Bieńko, Alina
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
dc.subject.por.fl_str_mv Molecular Medicine
Drug Discovery
SDG 3 - Good Health and Well-being
topic Molecular Medicine
Drug Discovery
SDG 3 - Good Health and Well-being
description funds granted under the Research Excellence Initiative of the University of Silesia in Katowice. The authors thank Dr inż. Mariola Siwy for measurements of elemental analysis. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-20T22:10:52Z
2023-07-13
2023-07-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/160196
url http://hdl.handle.net/10362/160196
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0022-2623
PURE: 75590433
https://doi.org/10.1021/acs.jmedchem.3c00255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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