Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure

Detalhes bibliográficos
Autor(a) principal: Choroba, Katarzyna
Data de Publicação: 2024
Outros Autores: Machura, Barbara, Erfurt, Karol, Casimiro, Ana Rita, Cordeiro, Sandra, Baptista, Pedro V., Fernandes, Alexandra R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/167688
Resumo: This work was cofinanced by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 (doi: 10.54499/UIDP/04378/2020) and UIDB/04378/2020 (doi: 10.54499/UIDB/04378/2020) of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB and doctoral grant 2021.08629.BD (S.C.), and project NANOHEAT (doi: 10.54499/2022.04315.PTDC) and the Research Excellence Initiative of the University of Silesia in Katowice (B.M.). K.C. acknowledges funding from the National Science Center of Poland grant MINIATURA no. 2022/06/X/ST4/00351. Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.
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spelling Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal StructureBiological Activities from 2D and 3D Tumor Spheroids to In Vivo ModelsMolecular MedicineDrug DiscoverySDG 3 - Good Health and Well-beingThis work was cofinanced by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 (doi: 10.54499/UIDP/04378/2020) and UIDB/04378/2020 (doi: 10.54499/UIDB/04378/2020) of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB and doctoral grant 2021.08629.BD (S.C.), and project NANOHEAT (doi: 10.54499/2022.04315.PTDC) and the Research Excellence Initiative of the University of Silesia in Katowice (B.M.). K.C. acknowledges funding from the National Science Center of Poland grant MINIATURA no. 2022/06/X/ST4/00351. Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.Eight 2,2′:6′,2″-terpyridines, substituted at the 4′-position with aromatic groups featuring variations in π-conjugation, ring size, heteroatoms, and methoxy groups, were employed to enhance the antiproliferative potential of [Cu2Cl2(R-terpy)2](PF6)2. Assessing the cytotoxicity in A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), and HCT116DoxR (colorectal carcinoma resistant to doxorubicin) and normal primary fibroblasts revealed that Cu(II) complexes with 4-quinolinyl, 4-methoxy-1-naphthyl, 2-furanyl, and 2-pyridynyl substituents showed superior therapeutic potential in HCT116DoxR cells with significantly reduced cytotoxicity in normal fibroblasts (42-129× lower). Besides their cytotoxicity, the Cu(II) complexes are able to increase intracellular ROS and interfere with cell cycle progression, leading to cell death by apoptosis and autophagy. Importantly, they demonstrated antimetastatic and antiangiogenic properties without in vivo toxicity. In accordance with their nuclear accumulation, the Cu(II) complexes are able to cleave pDNA and interact with bovine serum albumin, which is a good indication of their ability for internalization and transport toward tumor cells.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNChoroba, KatarzynaMachura, BarbaraErfurt, KarolCasimiro, Ana RitaCordeiro, SandraBaptista, Pedro V.Fernandes, Alexandra R.2024-05-23T00:22:44Z2024-04-112024-04-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article24application/pdfhttp://hdl.handle.net/10362/167688eng0022-2623PURE: 91715137https://doi.org/10.1021/acs.jmedchem.4c00119info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-09T01:38:41Zoai:run.unl.pt:10362/167688Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-09T01:38:41Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models
title Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
spellingShingle Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
Choroba, Katarzyna
Molecular Medicine
Drug Discovery
SDG 3 - Good Health and Well-being
title_short Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
title_full Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
title_fullStr Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
title_full_unstemmed Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
title_sort Copper(II) Complexes with 2,2′:6′,2″-Terpyridine Derivatives Displaying Dimeric Dichloro−μ-Bridged Crystal Structure
author Choroba, Katarzyna
author_facet Choroba, Katarzyna
Machura, Barbara
Erfurt, Karol
Casimiro, Ana Rita
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
author_role author
author2 Machura, Barbara
Erfurt, Karol
Casimiro, Ana Rita
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Choroba, Katarzyna
Machura, Barbara
Erfurt, Karol
Casimiro, Ana Rita
Cordeiro, Sandra
Baptista, Pedro V.
Fernandes, Alexandra R.
dc.subject.por.fl_str_mv Molecular Medicine
Drug Discovery
SDG 3 - Good Health and Well-being
topic Molecular Medicine
Drug Discovery
SDG 3 - Good Health and Well-being
description This work was cofinanced by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 (doi: 10.54499/UIDP/04378/2020) and UIDB/04378/2020 (doi: 10.54499/UIDB/04378/2020) of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB and doctoral grant 2021.08629.BD (S.C.), and project NANOHEAT (doi: 10.54499/2022.04315.PTDC) and the Research Excellence Initiative of the University of Silesia in Katowice (B.M.). K.C. acknowledges funding from the National Science Center of Poland grant MINIATURA no. 2022/06/X/ST4/00351. Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.
publishDate 2024
dc.date.none.fl_str_mv 2024-05-23T00:22:44Z
2024-04-11
2024-04-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/167688
url http://hdl.handle.net/10362/167688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0022-2623
PURE: 91715137
https://doi.org/10.1021/acs.jmedchem.4c00119
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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