Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury

Detalhes bibliográficos
Autor(a) principal: Rossi, Maxime
Data de Publicação: 2017
Outros Autores: Thierry, Antoine, Delbauve, Sandrine, Preyat, Nicolas, Soares, Miguel P., Roumeguère, Thierry, Leo, Oberdan, Flamand, Véronique, Le Moine, Alain, Hougardy, Jean-Michel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/739
Resumo: This work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016).
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spelling Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injuryAcute kidney injuryMonocytes and macrophagesTranslational immunologyThis work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016).Renal ischemia-reperfusion injury (IRI) is a major risk factor for delayed graft function in renal transplantation. Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1) mediates protection against IRI. However, the role of myeloid HO-1 during IRI remains poorly characterized. Mice with myeloid-restricted deletion of HO-1 (HO-1(M-KO)), littermate (LT), and wild-type (WT) mice were subjected to renal IRI or sham procedures and sacrificed after 24 hours or 7 days. In comparison to LT, HO-1(M-KO) exhibited significant renal histological damage, pro-inflammatory responses and oxidative stress 24 hours after reperfusion. HO-1(M-KO) mice also displayed impaired tubular repair and increased renal fibrosis 7 days after IRI. In WT mice, HO-1 induction with hemin specifically upregulated HO-1 within the CD11b(+) F4/80(lo) subset of the renal myeloid cells. Prior administration of hemin to renal IRI was associated with significant increase of the renal HO-1(+) CD11b(+) F4/80(lo) myeloid cells in comparison to control mice. In contrast, this hemin-mediated protection was abolished in HO-1(M-KO) mice. In conclusion, myeloid HO-1 appears as a critical protective pathway against renal IRI and could be an interesting therapeutic target in renal transplantation.Fonds de la Recherche Scientifique Médicale; Fonds Erasme pour la Recherche Médicale; Société Belge d’Urologie.Nature Publishing GroupARCARossi, MaximeThierry, AntoineDelbauve, SandrinePreyat, NicolasSoares, Miguel P.Roumeguère, ThierryLeo, OberdanFlamand, VéroniqueLe Moine, AlainHougardy, Jean-Michel2017-03-17T15:25:35Z2017-03-152017-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/739engScientific Reports 7, Article number: 197 (2017) doi:10.1038/s41598-017-00220-w10.1038/s41598-017-00220-winfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:08Zoai:arca.igc.gulbenkian.pt:10400.7/739Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:58.054446Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
title Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
spellingShingle Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
Rossi, Maxime
Acute kidney injury
Monocytes and macrophages
Translational immunology
title_short Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
title_full Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
title_fullStr Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
title_full_unstemmed Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
title_sort Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
author Rossi, Maxime
author_facet Rossi, Maxime
Thierry, Antoine
Delbauve, Sandrine
Preyat, Nicolas
Soares, Miguel P.
Roumeguère, Thierry
Leo, Oberdan
Flamand, Véronique
Le Moine, Alain
Hougardy, Jean-Michel
author_role author
author2 Thierry, Antoine
Delbauve, Sandrine
Preyat, Nicolas
Soares, Miguel P.
Roumeguère, Thierry
Leo, Oberdan
Flamand, Véronique
Le Moine, Alain
Hougardy, Jean-Michel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Rossi, Maxime
Thierry, Antoine
Delbauve, Sandrine
Preyat, Nicolas
Soares, Miguel P.
Roumeguère, Thierry
Leo, Oberdan
Flamand, Véronique
Le Moine, Alain
Hougardy, Jean-Michel
dc.subject.por.fl_str_mv Acute kidney injury
Monocytes and macrophages
Translational immunology
topic Acute kidney injury
Monocytes and macrophages
Translational immunology
description This work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016).
publishDate 2017
dc.date.none.fl_str_mv 2017-03-17T15:25:35Z
2017-03-15
2017-03-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/739
url http://hdl.handle.net/10400.7/739
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific Reports 7, Article number: 197 (2017) doi:10.1038/s41598-017-00220-w
10.1038/s41598-017-00220-w
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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