Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/739 |
Resumo: | This work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016). |
id |
RCAP_0932aa9c38296f8e5fa3ff48ac614310 |
---|---|
oai_identifier_str |
oai:arca.igc.gulbenkian.pt:10400.7/739 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injuryAcute kidney injuryMonocytes and macrophagesTranslational immunologyThis work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016).Renal ischemia-reperfusion injury (IRI) is a major risk factor for delayed graft function in renal transplantation. Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1) mediates protection against IRI. However, the role of myeloid HO-1 during IRI remains poorly characterized. Mice with myeloid-restricted deletion of HO-1 (HO-1(M-KO)), littermate (LT), and wild-type (WT) mice were subjected to renal IRI or sham procedures and sacrificed after 24 hours or 7 days. In comparison to LT, HO-1(M-KO) exhibited significant renal histological damage, pro-inflammatory responses and oxidative stress 24 hours after reperfusion. HO-1(M-KO) mice also displayed impaired tubular repair and increased renal fibrosis 7 days after IRI. In WT mice, HO-1 induction with hemin specifically upregulated HO-1 within the CD11b(+) F4/80(lo) subset of the renal myeloid cells. Prior administration of hemin to renal IRI was associated with significant increase of the renal HO-1(+) CD11b(+) F4/80(lo) myeloid cells in comparison to control mice. In contrast, this hemin-mediated protection was abolished in HO-1(M-KO) mice. In conclusion, myeloid HO-1 appears as a critical protective pathway against renal IRI and could be an interesting therapeutic target in renal transplantation.Fonds de la Recherche Scientifique Médicale; Fonds Erasme pour la Recherche Médicale; Société Belge d’Urologie.Nature Publishing GroupARCARossi, MaximeThierry, AntoineDelbauve, SandrinePreyat, NicolasSoares, Miguel P.Roumeguère, ThierryLeo, OberdanFlamand, VéroniqueLe Moine, AlainHougardy, Jean-Michel2017-03-17T15:25:35Z2017-03-152017-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/739engScientific Reports 7, Article number: 197 (2017) doi:10.1038/s41598-017-00220-w10.1038/s41598-017-00220-winfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:08Zoai:arca.igc.gulbenkian.pt:10400.7/739Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:58.054446Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
title |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
spellingShingle |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury Rossi, Maxime Acute kidney injury Monocytes and macrophages Translational immunology |
title_short |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
title_full |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
title_fullStr |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
title_full_unstemmed |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
title_sort |
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury |
author |
Rossi, Maxime |
author_facet |
Rossi, Maxime Thierry, Antoine Delbauve, Sandrine Preyat, Nicolas Soares, Miguel P. Roumeguère, Thierry Leo, Oberdan Flamand, Véronique Le Moine, Alain Hougardy, Jean-Michel |
author_role |
author |
author2 |
Thierry, Antoine Delbauve, Sandrine Preyat, Nicolas Soares, Miguel P. Roumeguère, Thierry Leo, Oberdan Flamand, Véronique Le Moine, Alain Hougardy, Jean-Michel |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Rossi, Maxime Thierry, Antoine Delbauve, Sandrine Preyat, Nicolas Soares, Miguel P. Roumeguère, Thierry Leo, Oberdan Flamand, Véronique Le Moine, Alain Hougardy, Jean-Michel |
dc.subject.por.fl_str_mv |
Acute kidney injury Monocytes and macrophages Translational immunology |
topic |
Acute kidney injury Monocytes and macrophages Translational immunology |
description |
This work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016). |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-17T15:25:35Z 2017-03-15 2017-03-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/739 |
url |
http://hdl.handle.net/10400.7/739 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports 7, Article number: 197 (2017) doi:10.1038/s41598-017-00220-w 10.1038/s41598-017-00220-w |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130574765424640 |