Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives

Detalhes bibliográficos
Autor(a) principal: Adão, Pedro
Data de Publicação: 2021
Outros Autores: Reboleira, João, Teles, Marco, Santos, Beatriz, Ribeiro, Nádia, Teixeira, Carlos M., Guedes, Mafalda, Pessoa, João Costa, Bernardino, Susana M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/5944
Resumo: The authors of MARE-Politécnico de Leiria acknowledge the MARE-Marine and Environmental Sciences Centre, Instituto Politécnico de Leiria, which is financed by national funds from FCT/MCTES (UID/MAR/04292/2019, UIDB/04292/2020) and the project “SmartBioR-Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate” (Centro01-0145-FEDER-000018) co-funded by Centro 2020, Portugal 2020 and European Regional Development Fund (FEDER). The authors of Centro de Química Estrutural acknowledge the financial support of Fundação para a Ciência e a Tecnologia (UIDB/0100/2020), the IST-UL Centers of the Portuguese NMR and Mass Spectrometry Networks (REM2013, RNNMR), RECI/QEQ-QIN/0189/2012, RECI/QEQ-MED/0330/2012, grants SFRH/BD/135797/2018 and PD/BD/106078/2015. FCT is also acknowledged through CeFEMA, under the strategic project UID/CTM/04540/2019.
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spelling Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivativesModified porphyranAntioxidant activityAntimicrobial activityThe authors of MARE-Politécnico de Leiria acknowledge the MARE-Marine and Environmental Sciences Centre, Instituto Politécnico de Leiria, which is financed by national funds from FCT/MCTES (UID/MAR/04292/2019, UIDB/04292/2020) and the project “SmartBioR-Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate” (Centro01-0145-FEDER-000018) co-funded by Centro 2020, Portugal 2020 and European Regional Development Fund (FEDER). The authors of Centro de Química Estrutural acknowledge the financial support of Fundação para a Ciência e a Tecnologia (UIDB/0100/2020), the IST-UL Centers of the Portuguese NMR and Mass Spectrometry Networks (REM2013, RNNMR), RECI/QEQ-QIN/0189/2012, RECI/QEQ-MED/0330/2012, grants SFRH/BD/135797/2018 and PD/BD/106078/2015. FCT is also acknowledged through CeFEMA, under the strategic project UID/CTM/04540/2019.The chemical modification of porphyran hydrocolloid is attempted, with the objective of enhancing its antioxidant and antimicrobial activities. Sulfated galactan porphyran is obtained from commercial samples of the red algae Porphyra dioica using Soxhlet extraction with water at 100ºC and precipitation with isopropyl alcohol. The extracted porphyran is then treated with modified L-tyrosines in aqueous medium in the presence of NaOH, at ca. 70ºC. The modified tyrosines L1 and L2 are prepared through a Mannich reaction with either thymol or 2,4-di-tert-butylphenol, respectively. While the reaction with 2,4-di-tert-butylphenol yields the expected tyrosine derivative, a mixture of products is obtained with thymol. The resulting polysaccharides are structurally characterized and the respective antioxidant and antimicrobial activities are determined. Porphyran treated with the N-(2-hydroxy-3,5-di-tert-butyl-benzyl)-L-tyrosine derivative, POR-L2, presents a noticeable superior radical scavenging and antioxidant activity compared to native porphyran, POR. Furthermore, it exhibited some antimicrobial activity against S. aureus. The surface morphology of films prepared by casting with native and modified porphyrans is studied by SEM/EDS. Both POR and POR-L2 present potential applicability in the production of films and washable coatings for food packaging with improved protecting characteristics.MDPIIC-OnlineAdão, PedroReboleira, JoãoTeles, MarcoSantos, BeatrizRibeiro, NádiaTeixeira, Carlos M.Guedes, MafaldaPessoa, João CostaBernardino, Susana M.2021-07-27T14:23:05Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5944engAdão, P.; Reboleira, J.; Teles, M.; Santos, B.; Ribeiro, N.; Teixeira, C.M.; Guedes, M.; Pessoa, J.C.; Bernardino, S. Enhancement of the Antioxidant and Antimicrobial Activities of Porphyran through Chemical Modification with Tyrosine Derivatives. Molecules 2021, 26, 2916. https://doi.org/10.3390/molecules 261029161420-304910.3390/molecules 26102916info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:52:00Zoai:iconline.ipleiria.pt:10400.8/5944Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:17.455340Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
title Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
spellingShingle Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
Adão, Pedro
Modified porphyran
Antioxidant activity
Antimicrobial activity
title_short Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
title_full Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
title_fullStr Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
title_full_unstemmed Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
title_sort Enhancement of the antioxidant and antimicrobial activities of porphyran through chemical modification with tyrosine derivatives
author Adão, Pedro
author_facet Adão, Pedro
Reboleira, João
Teles, Marco
Santos, Beatriz
Ribeiro, Nádia
Teixeira, Carlos M.
Guedes, Mafalda
Pessoa, João Costa
Bernardino, Susana M.
author_role author
author2 Reboleira, João
Teles, Marco
Santos, Beatriz
Ribeiro, Nádia
Teixeira, Carlos M.
Guedes, Mafalda
Pessoa, João Costa
Bernardino, Susana M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Adão, Pedro
Reboleira, João
Teles, Marco
Santos, Beatriz
Ribeiro, Nádia
Teixeira, Carlos M.
Guedes, Mafalda
Pessoa, João Costa
Bernardino, Susana M.
dc.subject.por.fl_str_mv Modified porphyran
Antioxidant activity
Antimicrobial activity
topic Modified porphyran
Antioxidant activity
Antimicrobial activity
description The authors of MARE-Politécnico de Leiria acknowledge the MARE-Marine and Environmental Sciences Centre, Instituto Politécnico de Leiria, which is financed by national funds from FCT/MCTES (UID/MAR/04292/2019, UIDB/04292/2020) and the project “SmartBioR-Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate” (Centro01-0145-FEDER-000018) co-funded by Centro 2020, Portugal 2020 and European Regional Development Fund (FEDER). The authors of Centro de Química Estrutural acknowledge the financial support of Fundação para a Ciência e a Tecnologia (UIDB/0100/2020), the IST-UL Centers of the Portuguese NMR and Mass Spectrometry Networks (REM2013, RNNMR), RECI/QEQ-QIN/0189/2012, RECI/QEQ-MED/0330/2012, grants SFRH/BD/135797/2018 and PD/BD/106078/2015. FCT is also acknowledged through CeFEMA, under the strategic project UID/CTM/04540/2019.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-27T14:23:05Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/5944
url http://hdl.handle.net/10400.8/5944
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Adão, P.; Reboleira, J.; Teles, M.; Santos, B.; Ribeiro, N.; Teixeira, C.M.; Guedes, M.; Pessoa, J.C.; Bernardino, S. Enhancement of the Antioxidant and Antimicrobial Activities of Porphyran through Chemical Modification with Tyrosine Derivatives. Molecules 2021, 26, 2916. https://doi.org/10.3390/molecules 26102916
1420-3049
10.3390/molecules 26102916
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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