Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer

Detalhes bibliográficos
Autor(a) principal: Alves, Celso
Data de Publicação: 2018
Outros Autores: Pinteus, Susete, Rodrigues, Ana, Horta, André, Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/4973
Resumo: This study had the support of the Fundação para a Ciência e a Tecnologia (FCT) through Red2Discovery Project (PTDC/MAR‑BIO/6149/2014), co‑financed by COMPETE (POCI‑01‑0145‑FEDER‑016791), and Strategic Project UID/MAR/04292/2013 granted to MARE and the support of the FP7 EU project “BAMMBO: Sustainable Production of Biologically Active Molecules of Marine Based Origin” (FP7 n 265896/http//www.bammbo. eu). C.A, S.P. and A.H. are financially supported by a grant from FCT Fundação para a Ciência e Tecnologia (SFRH/BD/97764/2013, SFRH/ BD/96203/2013 and SFRH/BD/120250/2016, respectively).
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spelling Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal CancerBioactive compoundsCaco‑2 cellsMarine natural productsRed macroalgaeSeaweedThis study had the support of the Fundação para a Ciência e a Tecnologia (FCT) through Red2Discovery Project (PTDC/MAR‑BIO/6149/2014), co‑financed by COMPETE (POCI‑01‑0145‑FEDER‑016791), and Strategic Project UID/MAR/04292/2013 granted to MARE and the support of the FP7 EU project “BAMMBO: Sustainable Production of Biologically Active Molecules of Marine Based Origin” (FP7 n 265896/http//www.bammbo. eu). C.A, S.P. and A.H. are financially supported by a grant from FCT Fundação para a Ciência e Tecnologia (SFRH/BD/97764/2013, SFRH/ BD/96203/2013 and SFRH/BD/120250/2016, respectively).Background: The marine environment has shown to be an interesting source of new antitumor agents, representing an important tool in cancer research. Objective: The aim of this study was to evaluate the antitumor activities of 12 algae from Peniche coast (Portugal) on an in vitro model of human colorectal cancer (Caco‑2 cells). Materials and Methods: The antitumor potential was accessed by evaluating Caco‑2 cell’s viability and proliferation through the 3‑[4, 5‑dimethylthiazol‑2‑yl]‑2, 5‑diphenyl tetrazolium bromide and calcein‑AM methods. Results: The dichloromethane extracts of Asparagopsis armata and Sphaerococcus coronopifolius induced the highest decrease on cell’s viability (1 mg/mL; 24 h), 98.96% ± 0.39% and 98.08% ± 0.89%, respectively, followed by the methanolic extracts of S. coronopifolius (96.47% ± 1.26%) and A. armata (92.68% ± 1.17%). Regarding cell proliferation, the highest decrease of Caco‑2 cell’s proliferation (1 mg/mL; 24 h) was induced by the dichloromethane extract of A. armata (100% ± 0.48%), S. coronopifolius (99.04 ± 0.51%), and Plocamium cartilagineum (95.05% ± 1.19%). The highest potency was shown by the dichloromethane extract of S. coronopifolius in both, cytotoxicity and antiproliferative tests, with an IC50 of 21.3 and 36.5 µg/mL, respectively. Conclusion: The extracts of A. armata and S. coronopifolius are promising sources of new bioactive molecules with application in cancer therapeutics.Medknow PublicationsIC-OnlineAlves, CelsoPinteus, SuseteRodrigues, AnaHorta, AndréPedrosa, Rui2020-06-30T15:24:08Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/4973engAlves C, Pinteus S, Rodrigues A, Horta A, Pedrosa R. Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer. Phcog Res 2018;10:24-30.0976-483610.4103/pr.pr_151_16info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-26T18:18:09Zoai:iconline.ipleiria.pt:10400.8/4973Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T18:18:09Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
title Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
spellingShingle Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
Alves, Celso
Bioactive compounds
Caco‑2 cells
Marine natural products
Red macroalgae
Seaweed
title_short Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
title_full Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
title_fullStr Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
title_full_unstemmed Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
title_sort Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer
author Alves, Celso
author_facet Alves, Celso
Pinteus, Susete
Rodrigues, Ana
Horta, André
Pedrosa, Rui
author_role author
author2 Pinteus, Susete
Rodrigues, Ana
Horta, André
Pedrosa, Rui
author2_role author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Alves, Celso
Pinteus, Susete
Rodrigues, Ana
Horta, André
Pedrosa, Rui
dc.subject.por.fl_str_mv Bioactive compounds
Caco‑2 cells
Marine natural products
Red macroalgae
Seaweed
topic Bioactive compounds
Caco‑2 cells
Marine natural products
Red macroalgae
Seaweed
description This study had the support of the Fundação para a Ciência e a Tecnologia (FCT) through Red2Discovery Project (PTDC/MAR‑BIO/6149/2014), co‑financed by COMPETE (POCI‑01‑0145‑FEDER‑016791), and Strategic Project UID/MAR/04292/2013 granted to MARE and the support of the FP7 EU project “BAMMBO: Sustainable Production of Biologically Active Molecules of Marine Based Origin” (FP7 n 265896/http//www.bammbo. eu). C.A, S.P. and A.H. are financially supported by a grant from FCT Fundação para a Ciência e Tecnologia (SFRH/BD/97764/2013, SFRH/ BD/96203/2013 and SFRH/BD/120250/2016, respectively).
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2020-06-30T15:24:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/4973
url http://hdl.handle.net/10400.8/4973
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Alves C, Pinteus S, Rodrigues A, Horta A, Pedrosa R. Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer. Phcog Res 2018;10:24-30.
0976-4836
10.4103/pr.pr_151_16
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Medknow Publications
publisher.none.fl_str_mv Medknow Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817547260397879296

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